Boning

Boning Uses, Dosage, Side Effects, Food Interaction and all others data.

Boning is a second generation, nitrogen containing bisphosphonate similar to neridronic acid and alendronic acid. Boning was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as ibandronic acid, zoledronic acid, minodronic acid, and risedronic acid are becoming more popular.

Boning was granted FDA approval on 31 October 1991.

Boning is a second generation, nitrogen containing bisphosphonate that inhibits osteoclast mediated bone loss It has a wide therapeutic index and a long duration of action as it can be given every 3-4 weeks for certain indications. Patients should be counselled regarding the risk of elevated blood urea nitrogen, renal tubular necrosis, and nephrotoxicity.

Boning
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Boning
Generic	Pamidronic acid
Pamidronic acid Other Names	Acide pamidronique, Acido pamidronico, Acidum pamidronicum, Pamidronate, Pamidronic acid
Type
Formula	C₃H₁₁NO₇P₂
Weight	Average: 235.0695 Monoisotopic: 235.001074735
Protein binding	Pamidronate is approximately 54% protein bound in serum.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	China
Last Updated:	September 19, 2023 at 7:00 am

Uses

Boning is a bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.

Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.

Boning is also used to associated treatment for these conditions: Hypercalcemia of Malignancy, Osteolytic lesion, Paget’s Disease, Osteolytic Bone metastases

How Boning works

Bisphosphonates are taken into the bone where they bind to hydroxyapatite. Bone resorption by osteoclasts causes local acidification, releasing the bisphosphonate, which is taken into the osteoclast by fluid-phase endocytosis. Endocytic vesicles become acidified, releasing bisphosphonates into the cytosol of osteoclasts where they act.

Osteoclasts mediate resorption of bone. When osteoclasts bind to bone they form podosomes, ring structures of F-actin. Disruption of the podosomes causes osteoclasts to detach from bones, preventing bone resorption.

Nitrogen containing bisphosphonates such as pamidronate are known to induce apoptosis of hematopoietic tumor cells by inhibiting the components of the mevalonate pathway farnesyl diphosphate synthase, farnesyl diphosphate, and geranylgeranyl diphosphate. These components are essential for post-translational prenylation of GTP-binding proteins like Rap1. The lack of prenylation of these proteins interferes with their function, and in the case of Rap1, leads to apoptosis. pamidronate also activated caspases 3 and 9 which further contribute to apoptosis.

Toxicity

Patients experiencing and overdose may present with hypocalcemia, fever, hypotension, and taste perversion. Overdose can be managed by symptomatic and supportive treatment which may include the administration of steroids and intravenous calcium.

Food Interaction

No interactions found.

Elimination Route

In patients with a creatinine clearance >90mL/min, a 90mg intravenous dose reached a C_max of 1.92±1.08µg/mL, with a T_max of 4h, and an AUC of 10.2±6.95µg*h/mL.

In patients with a creatinine clearance 61-90mL/min, a 90mg intravenous dose reached a C_max of 1.86±0.50µg/mL, with a T_max of 4h, and an AUC of 10.7—3.91µg*h/mL.[A203264

In patients with a creatinine clearance 30-60mL/min, a 90mg intravenous dose reached a C_max of 1.84±0.58µg/mL, with a T_max of 4h, and an AUC of 10.1±3.38µg*h/mL.

In patients with a creatinine clearance max of 1.93±0.53µg/mL, with a T_max of 4h, and an AUC of 34.0±8.37µg*h/mL.