Boots Thrush Oral Capsule and Duo - Boots Thrush
Boots Thrush Oral Capsule and Duo - Boots Thrush Uses, Dosage, Side Effects, Food Interaction and all others data.
Boots Thrush Oral Capsule and Duo - Boots Thrush is a broad spectrum antifungal. It also exhibits activity against Trichomonus, Staphylococci, Streptococci and Bacteroides. Boots Thrush Oral Capsule and Duo - Boots Thrush kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes resulting in increased membrane permeability and leakage of essential constituents of the fungal cells. Boots Thrush Oral Capsule and Duo - Boots Thrush acts reliably on dermatophytes, yeasts and other fungi; it is also effective against Trichomonas vaginalis and Gram-positive microorganisms (streptococci/ staphylococci) and Gram-negative microorganisms (bacteroides/ Haemophilus vaginalis).
Boots Thrush Oral Capsule and Duo - Boots Thrush is a broad-spectrum antifungal agent that inhibits the growth of pathogenic yeasts by changing the permeability of cell membranes. The action of clotrimazole is fungistatic at concentrations of drug up to 20 mcg/mL and may be fungicidal in vitro against Candida albicans and other species of the genus Candida at higher concentrations . Unfortunately, resistance to clotrimazole, which was rare in the past, is now common in various patient populations .
Boots Thrush Oral Capsule and Duo - Boots Thrush is generally considered to be a fungistatic, and not a fungicidal drug, although this contrast is not absolute, as clotrimazole shows fungicidal properties at higher concentrations .
| Trade Name | Boots Thrush Oral Capsule and Duo - Boots Thrush |
| Availability | Prescription only |
| Generic | Clotrimazole |
| Clotrimazole Other Names | Clotrimazol, Clotrimazole, Clotrimazolum |
| Related Drugs | fluconazole, nystatin, Diflucan, itraconazole, miconazole |
| Type | |
| Formula | C22H17ClN2 |
| Weight | Average: 344.837 Monoisotopic: 344.108026261 |
| Protein binding | 98% |
| Groups | Approved, Vet approved |
| Therapeutic Class | Drugs for subcutaneous and systemic mycoses, Topical Antifungal preparations |
| Manufacturer | THE BOOTS COMPANY PLC |
| Available Country | United Kingdom |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
The confirmed indication for Boots Thrush Oral Capsule and Duo - Boots Thrush include:
- All dermatomycoses due to dermatophytes (e.g. Trichophyton species).
- All dermatomycoses due to yeasts (Candida species).
- Dermatomycoses due to moulds and other fungi.
- Skin diseases showing superinfections with these fungi.
To the dermatomycoses listed under 1-4 belong for example, interdigital myocoses (e.g. athlete’s foot), paronychias (associated with nail mycoses), myocoses in skin folds, Candida vulvitis, Candida balanitis, Pityriasis versicolor, erythrasma.
Boots Thrush Oral Capsule and Duo - Boots Thrush rectal preparation is used for vaginal itching, burning and discharge associated with recurrent vaginal yeast infections (Vaginal candidiasis) and also in viginitis due to Candida species as well as Mycotic infections complicated by other microorganisms sensitive to the drug.
Boots Thrush Oral Capsule and Duo - Boots Thrush Sterile Eye Ointment is used for the treatment of fungal keratitis due to filamentous fungi and Candida species.
Boots Thrush Oral Capsule and Duo - Boots Thrush Ear Drop is used for the treatment of fungal infections of the ear.
Boots Thrush Oral Capsule and Duo - Boots Thrush is also used to associated treatment for these conditions: Balanitis candida, Candidiasis, Dermatitis, Dermatomycoses, Ear infection fungal, Erythrasma, Fungal Vaginal Infections, Fungal skin infection, Genital candidiasis, Inflammation, Mixed Vaginal Infections, Oropharyngeal Candidiasis, Pityriasis versicolor, Pyoderma, Ringworm, Skin Infections, Skin candida, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea inguinalis, Trichophytosis, Vaginal Candidiasis, Vaginal Mycosis, Vulvitis, Cutaneous candidiasis, Infection mycotic, Susceptible Bacterial Infections, Symptomatic Tinea Corporis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Symptomatic Tinea Cruris caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Symptomatic Tinea Pedis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Tinea versicolor caused by Malassezia infection
How Boots Thrush Oral Capsule and Duo - Boots Thrush works
Boots Thrush Oral Capsule and Duo - Boots Thrush acts primarily by damaging the permeability barrier in the cell membrane of fungi. Boots Thrush Oral Capsule and Duo - Boots Thrush causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane ,. Because ergosterol directly promotes the growth of fungal cells in a hormone‐like fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth .
Though decreased ergosterol, due to the inhibition of lanosterol 14-demethylase (also known as CYP51) is accepted to be primarily responsible for the antimycotic properties of clotrimazole, this drug also shows other pharmacological effects. These include the inhibition of sarcoplasmic reticulum Ca2+‐ATPase, depletion of intracellular calcium, and blocking of calcium‐dependent potassium channels and voltage‐dependent calcium channels . The action of clotrimazole on these targets accounts for other effects of this drug that are separate from its antimycotic activities .
Dosage
Boots Thrush Oral Capsule and Duo - Boots Thrush dosage
Topical
Wash skin with soap and water and dry thoroughly. Apply a thin layer of the cream or solution 2-3 times daily and gently massage over affected area as directed by the doctor. For Athlete’s foot, pay special attention to the spaces between the toes. Best results in Athlete's foot and ringworm are usually obtained with 4 weeks use of this product. The cream should be applied two or three times daily for one month or for at least two weeks after the disappearance of all signs of infection. If satisfactory results have not occurred within these times consultation with doctor is essential. For best results, follow directions and continue treatment for length of time indicated. The duration of treatment varies; it depends among other factors on the extent and localization of the disease.
Recommended duration of treatment :
- Dermatomycoses: 3-4 weeks
- Candida vulvitis and candida balanitis: 1-2 weeks
- Erythrasma and pityriasis versicolor (approx.): 3 weeks
- In fungal infection of the feet, to prevent relapses:Treatment should be continued for about 2 weeks beyond the disappearance of all signs of disease.
Boots Thrush Oral Capsule and Duo - Boots Thrush cream is odourless, can be washed off and does not stain.
Rectal
First infections: In general, a 3-day treatment is sufficient for Candida vaginitis. On 3 consecutive nights, Boots Thrush Oral Capsule and Duo - Boots Thrush 200 mg vaginal preparation is inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent.
Re-infections: In general, a 6-day treatment is sufficient. This applies also to mixed infections with the above-mentioned causative organisms. On six consecutive nights, 1 Boots Thrush Oral Capsule and Duo - Boots Thrush 100 mgvaginal preparation is inserted as deeply as possible into the vagina. If necessary, 2 Boots Thrush Oral Capsule and Duo - Boots Thrush 100 mg(1 in the morning and 1 in the evening) or 1 Boots Thrush Oral Capsule and Duo - Boots Thrush 200 mg daily can be used for 6-12 days. Treatment should be timed so as to avoid the menstrual period and be finished before the onset of menstruation. To avoid re-infection, the partner should undergo local treatment with Boots Thrush Oral Capsule and Duo - Boots Thrush cream at the same time.
Boots Thrush Oral Capsule and Duo - Boots Thrush 500 mg vaginal preparation: Single dose, complete treatment with one vaginal tablet. The tablet should be inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent. It is recommended that the treatment should be timed so as to avoid the menstrual period. For prevention of re-infection the partner should be treated locally with Boots Thrush Oral Capsule and Duo - Boots Thrush cream at the same time.
Boots Thrush Oral Capsule and Duo - Boots Thrushvaginal preparation are colorless and do not stain the underwear.
Eye
Adult: It should be applied thinly and evenly to the conjunctival sac every 4 hours daily or as advised by a physician.
Children: Safety and effectiveness in children have been established for Boots Thrush Oral Capsule and Duo - Boots Thrush when used as indicated and in the recommended dosage.
Ear
Instill 2-3 drops of Clarizol Ear Drops in the affected ear two or three times daily.The treatment should be continued for at least two weeks after the disappearance of all signs of infection to prevent re-infection.
For the treatment to become a complete success, reliable and sufficiently long application of Boots Thrush Oral Capsule and Duo - Boots Thrush cream is important. The duration of treatment varies; it depends among other factors on the extent and localisation of the disease.
Side Effects
Boots Thrush Oral Capsule and Duo - Boots Thrush is generally well tolerated after local application but the few side effects have been reported infrequently like erythema, stinging, blistering, peeling, oedema, pruritus, urticaria and general irritation.
Since there is practically no Boots Thrush Oral Capsule and Duo - Boots Thrush absorption through the vaginal skin, no systemic effect is expected. The local tolerance of Boots Thrush Oral Capsule and Duo - Boots Thrush vaginal tablet is generally good. Local irritation or burning sensation may occur in a very few cases but these symptoms are not considered harmful.
Rarely patients may experience burning or irritation immediately after applying the ointment.
Toxicity
Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps. As with all topical agents, skin sensitization may result .
Oral LD50 (rat): 708 mg/kg; Intraperitoneal LD50 (rat): 445 mg/kg; Subcutaneous LDLO (rat): 10 g/kg; Oral LD50 (mouse): 761 mg/kg; Subcutaneous LDLO (mouse): 10 g/kg; Intraperitoneal LD50 (mouse): 108 mg/kg;
Overdose
This drug poses no risk of acute intoxication, as it is unlikely to occur following a single vaginal or dermal application of an overdose (application over a large area under conditions favorable to absorption) or accidental oral ingestion. There is no specific antidote .
Effects on Fertility
No human studies of the effects of clotrimazole on fertility have been conducted; however, animal studies have not shown any effects on the drug on fertility .
Use in Pregnancy
There are limited data regarding the use of clotrimazole in pregnant women. Animal studies do not show direct or indirect harmful effects on reproduction. Although the topical application of clotrimazole may result in very low serum and tissue levels, the use of clotrimazole topical cream by pregnant women is not recommended unless it is advised by the prescribing physician. Boots Thrush Oral Capsule and Duo - Boots Thrush topical cream should not be used in the first trimester of pregnancy unless it is considered by the physician to be essential to patient well-being .
Use in Breastfeeding
Available pharmacodynamic/toxicological studies in animals have shown excretion of clotrimazole/metabolites in breastmilk. Boots Thrush Oral Capsule and Duo - Boots Thrush should not be administered during breastfeeding. Although the topical application of clotrimazole has resulted in very low serum and tissue levels, the use of clotrimazole topical cream by lactating women is not recommended unless it recommended by the prescribing physician .
Precaution
If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy. Boots Thrush Oral Capsule and Duo - Boots Thrush solution is not intended for ophthalmic use. Avoid contact with eyes upon topical application. Children 3 yrs. Pregnancy, lactation. If irritation or sensitivity develops with the use of Boots Thrush Oral Capsule and Duo - Boots Thrush ointment, treatment should be discontinued.
Interaction
There have been reports of a heat reaction when this medication used concomitantly with Sofradex drops in the ear.
Antagonism with polyene antibiotics.
Food Interaction
No interactions found.Boots Thrush Oral Capsule and Duo - Boots Thrush Drug Interaction
Moderate: budesonide / formoterol, alprazolamUnknown: aspirin, diphenhydramine, docusate, duloxetine, omega-3 polyunsaturated fatty acids, fluticasone nasal, furosemide, pregabalin, polyethylene glycol 3350, esomeprazole, acetaminophen, albuterol, montelukast, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, cetirizine
Boots Thrush Oral Capsule and Duo - Boots Thrush Disease Interaction
Volume of Distribution
The topical form is minimally absorbed in the serum and tissues . Boots Thrush Oral Capsule and Duo - Boots Thrush is a lipophilic drug , and has been shown to be secreted in breastmilk in animal studies . There are limited data available regarding the volume of distribution following oral troche administration.
Elimination Route
Because clotrimazole is generally not significantly absorbed, drug interactions are not a major issue with its use .
Elimination Route
Mainly hepatic .
Pregnancy & Breastfeeding use
Pregnancy:Boots Thrush Oral Capsule and Duo - Boots Thrush is recommended during pregnancy only after first consulting a doctor.
Lactation:Because systemic absorption of clotrimazole following topical application is marginal, there should be no risk for the infant during lactation.
Contraindication
Hypersensitivity to clotrimazole.
Acute Overdose
Supportive measures should be taken incase of accidental oral ingestion.
In case of accidental oral ingestion, supportive measures should be taken.
Interaction with other Medicine
There have been reports of a heat reaction when this medication used concomitantly with Sofradex drops in the ear.
Storage Condition
Store at a cool and dry place. Protect from light. Do not freeze.
Innovators Monograph
You find simplified version here Boots Thrush Oral Capsule and Duo - Boots Thrush
Boots Thrush Oral Capsule and Duo - Boots Thrush contains Clotrimazole see full prescribing information from innovator Boots Thrush Oral Capsule and Duo - Boots Thrush Monograph, Boots Thrush Oral Capsule and Duo - Boots Thrush MSDS, Boots Thrush Oral Capsule and Duo - Boots Thrush FDA label
FAQ
What is Boots Thrush Oral Capsule and Duo - Boots Thrush used for?
Boots Thrush Oral Capsule and Duo - Boots Thrush is used to treat vaginal yeast infections, oral thrush, diaper rash, pityriasis versicolor, and types of ringworm including athlete's foot and jock itch. It is also used to treat skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections (candidiasis). Boots Thrush Oral Capsule and Duo - Boots Thrush is used to treat skin infections caused by a fungus (yeast).
How safe is Boots Thrush Oral Capsule and Duo - Boots Thrush?
Food and Drug Administration and is safe and effective when used according to the Boots Thrush Oral Capsule and Duo - Boots Thrush facts label directions.
How does Boots Thrush Oral Capsule and Duo - Boots Thrush work?
Boots Thrush Oral Capsule and Duo - Boots Thrush work by killing the fungus (yeast) that is causing the infection. Boots Thrush Oral Capsule and Duo - Boots Thrush kills fungus by causing holes to appear in its cell membrane and the contents leak out.
What are the common side effects of Boots Thrush Oral Capsule and Duo - Boots Thrush?
Common side effects of Boots Thrush Oral Capsule and Duo - Boots Thrush are include: Burning, stinging, swelling, irritation, redness, pimple-like bumps, tenderness, or flaking of the treated skin may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Is Boots Thrush Oral Capsule and Duo - Boots Thrush safe during pregnancy?
Boots Thrush Oral Capsule and Duo - Boots Thrush is generally considered safe for pregnant women to use. If you are using the pessary to treat vaginal thrush during pregnancy it is recommended that you insert it with your fingers rather than with the applicator provided.
Is Boots Thrush Oral Capsule and Duo - Boots Thrush safe during breastfeeding?
Boots Thrush Oral Capsule and Duo - Boots Thrush is generally considered safe to use while you're breastfeeding. If your baby is being treated for oral thrush you can carry on breastfeeding but you'll need to be treated at the same time. Apply Boots Thrush Oral Capsule and Duo - Boots Thrush cream on and around your nipples after each time you breastfeed your baby.
Can I drink alcohol with Boots Thrush Oral Capsule and Duo - Boots Thrush?
Yes, you can drink alcohol while using Boots Thrush Oral Capsule and Duo - Boots Thrush.
When should be taken of Boots Thrush Oral Capsule and Duo - Boots Thrush?
Apply Boots Thrush Oral Capsule and Duo - Boots Thrush to the affected area 2 to 3 times a day. It will work better if you use it 3 times a day. If the affected area is large or hairy, it's best to use either the spray or solution.
Should Boots Thrush Oral Capsule and Duo - Boots Thrush be taken with food?
Do not eat or drink while Boots Thrush Oral Capsule and Duo - Boots Thrush is in your mouth.
How long does Boots Thrush Oral Capsule and Duo - Boots Thrush take to work?
Boots Thrush Oral Capsule and Duo - Boots Thrush usually takes 7 days for fungal infections to improve. Apply Boots Thrush Oral Capsule and Duo - Boots Thrush to the infected area 2 or 3 times a day for at least 2 weeks.
What is the half life of Boots Thrush Oral Capsule and Duo - Boots Thrush?
The elimination half-life of Boots Thrush Oral Capsule and Duo - Boots Thrush is 3.5-5 hours.
Can I take Boots Thrush Oral Capsule and Duo - Boots Thrush for long time?
Do not use Boots Thrush Oral Capsule and Duo - Boots Thrush cream, spray or solution for more than 4 weeks, unless a doctor tells you to.
What happens if I use too much Boots Thrush Oral Capsule and Duo - Boots Thrush?
Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time.
When should I not use Boots Thrush Oral Capsule and Duo - Boots Thrush?
Do not use Boots Thrush Oral Capsule and Duo - Boots Thrush cream, spray or solution for more than 4 weeks, unless a doctor tells you to. A fungal infection can become resistant to Boots Thrush Oral Capsule and Duo - Boots Thrush, which means it will no longer work properly.
How many times a day can I use Boots Thrush Oral Capsule and Duo - Boots Thrush?
Adults and children use two times a day, morning and evening.
Does Boots Thrush Oral Capsule and Duo - Boots Thrush stop itching?
Boots Thrush Oral Capsule and Duo - Boots Thrush reduces vaginal burning, itching, and discharge that may occur with this condition.
Does Boots Thrush Oral Capsule and Duo - Boots Thrush raise blood sugar?
Boots Thrush Oral Capsule and Duo - Boots Thrush can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis.
Can a man use Boots Thrush Oral Capsule and Duo - Boots Thrush cream?
Boots Thrush Oral Capsule and Duo - Boots Thrush can be used for men and women.
Will Boots Thrush Oral Capsule and Duo - Boots Thrush cure toenail fungus?
Over the counter fungal creams like Boots Thrush Oral Capsule and Duo - Boots Thrush don't work well for treating toenail fungus.
Does Boots Thrush Oral Capsule and Duo - Boots Thrush affect the liver?
The cause of the serum enzyme elevations during Boots Thrush Oral Capsule and Duo - Boots Thrush therapy is unknown, but many of the antifungal azoles have been implicated in causing liver injury.
Can I overdose on Boots Thrush Oral Capsule and Duo - Boots Thrush?
An overdose of Boots Thrush Oral Capsule and Duo - Boots Thrush topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.
What happens if I stop taking Boots Thrush Oral Capsule and Duo - Boots Thrush?
Stopping the Boots Thrush Oral Capsule and Duo - Boots Thrush too early may allow fungus to continue to grow, which may result in a relapse of the infection. Inform your doctor if your condition persists or worsens.
Does Boots Thrush Oral Capsule and Duo - Boots Thrush dry out skin?
Burning, tingling, dry skin, or stinging may occur.
