Brabio

Brabio Uses, Dosage, Side Effects, Food Interaction and all others data.

Brabio acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis.

Brabio acetate was originally designed to mimic a protein in myelin, called myelin basic protein, with the intention of inducing EAE (an animal model of MS). Quite to the contrary, it was found to suppress the disease and as a result came to be trialed in human MS. There is some evidence that Brabio acetate converts the body's immune response from a Th1 type to a Th2 one, promotes suppressor T cells or acts as an altered peptide ligand. Studies in animals and in vitro systems suggest that upon its administration, glatiramer acetate-specific suppressor T-cells are induced and activated in the periphery. Some fraction of the injected material, either intact or partially hydrolyzed, is presumed to enter the lymphatic circulation, enabling it to reach regional lymph nodes, and some may enter the systemic circulation intact.

Trade Name Brabio
Availability Prescription only
Generic Glatiramer
Glatiramer Other Names (T,G)-A-L, COP 1, COP-1, Copolymer I (synthetic peptide), Copolymer-1
Related Drugs Gilenya, Tysabri, Vumerity, Copaxone, Tecfidera, Aubagio, Avonex
Type Injection
Formula C254H422N70O72
Weight 7000.0 Da (range 5000-9000)
Groups Approved, Investigational
Therapeutic Class
Manufacturer Mylan
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Brabio
Brabio

Uses

Brabio is an immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS).

For reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis.

Brabio is also used to associated treatment for these conditions: Disseminated Sclerosis

How Brabio works

Brabio acetate (GA) exhibits strong and promiscuous binding to MHC molecules (HLA DRB1* variants) and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression. Furthermore, the GA-specific cells in the brain express the anti-inflammatory cytokines IL-10 and transforming growth factor beta, in addition to brain-derived neurotrophic factor, whereas they do not express the inflammatory cytokine IFN-gamma. Recent evidence also suggests that Brabio acetate directly inhibits dendritic cells and monocytes - both of which are circulating antigen presenting cells.

Toxicity

Adverse reactions include injection site reactions, vasodilatation, chest pain, asthenia, infection, pain, nausea, arthralgia, anxiety, and hypertonia.

Food Interaction

No interactions found.

Innovators Monograph

You find simplified version here Brabio

*** Taking medicines without doctor's advice can cause long-term problems.
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