Bricarex Dx
Bricarex Dx Uses, Dosage, Side Effects, Food Interaction and all others data.
Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Dextromethorphan is an opioid-like molecule indicated in combination with other medication in the treatment of coughs and pseudobulbar affect. It has a moderate therapeutic window, as intoxication can occur at higher doses. Dextromethorphan has a moderate duration of action. Patients should be counselled regarding the risk of intoxication.
| Trade Name | Bricarex Dx |
| Generic | Dextromethorphan + Chlorphenamine Maleate |
| Weight | 10mg |
| Type | Syrup |
| Therapeutic Class | |
| Manufacturer | Zydus Healthcare Limited |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dextromethorphan is used for Chronic dry cough or unproductive cough; Acute dry cough which is interfering with normal function or sleep.
Bricarex Dx is also used to associated treatment for these conditions: Allergic cough, Common Cold, Common Cold/Flu, Cough, Cough caused by Common Cold, Coughing caused by Allergies, Coughing caused by Bronchitis, Coughing caused by Flu caused by Influenza, Fever, Flu caused by Influenza, Headache, Irritative cough, Itching of the nose, Itching of the throat, Nasal Congestion, Pseudobulbar affect, Rhinorrhoea, Sneezing, Upper respiratory symptoms, Watery itchy eyes, Airway secretion clearance therapy, Bronchodilation, Oropharyngeal antisepsis
How Bricarex Dx works
Dextromethorphan is an agonist of NMDA and sigma-1 receptors. It is also an antagonist of α3/β4 nicotinic receptors.[A10589] However, the mechanism by which dextromethorphan's receptor agonism and antagonism translates to a clinical effect is not well understood.
Dosage
Bricarex Dx dosage
Adults and Children over 12 years: 15 to 30 mg three to four times per day. However, 60 mg doses up to four times per day have been used without increased side effects.
Children between 6 and 12 years: 5-15 mg up to four times per day.
Children between 2 and 6 years: 2.5-5 mg up to four times per day.
Side Effects
Adverse effects with Dextromethorphan are rare, but nausea and dizziness sometimes occur. The drug produces no analgesia or addiction and little or no CNS depression. Excitation, confusion and respiratory depression may occur after overdosage.
Toxicity
A dextromethorphan overdose may present as nausea, vomiting, stupor, coma, respiratory depression, seizures, tachycardia, hyperexcitability, toxic psychosis, ataxia, nystagmus, dystonia, blurred vision, changes in muscle reflexes, and serotonin syndrome. Overdose should be managed through symptomatic and supportive measures.
Precaution
Do not use Dextromethorphan to control a cough that is associated with smoking, asthma, or emphysema, or a cough that is productive (produces sputum or phlegm).
Interaction
The following medicines should be taken carefully while concomitantly use with Dextromethorphan: Amiodarone, Fluoexetine, Quinidine, CNS depressants and Monoamine oxidase (MAO) inhibitors.
Volume of Distribution
The volume of distribution of dextromethorphan is 5-6.7L/kg.
Elimination Route
A 30mg oral dose of dextromethorphan reaches a Cmax of 2.9 ng/mL, with a Tmax of 2.86 h, and an AUC of 17.8 ng*h/mL.
Half Life
Dextromethorphan has a half life of 3-30 hours.
Pregnancy & Breastfeeding use
Pregnancy: Adequate and well-controlled studies in human have not been done. However, Dextromethorphan has not been reported to cause birth defects.
Lactation: It is not known whether dextromethorphan passes into breast milk. However, Dextromethorphan has not been reported to cause problems in nursing babies.
Contraindication
Hypersensitivity to Dextromethorphan or any other component.
Acute Overdose
Symptoms: In mild overdose, tachycardia, hypertension, vomiting, mydriasis, diaphoresis, nystagmus, euphoria, loss of motor coordination, and giggling; in moderate intoxication, in addition to those listed above, hallucinations and a plodding ataxic gait; in severely intoxication, agitation or somnolence.
Management: treatment is symptomatic and supportive. Naloxone may be useful in reversing toxicity.
Storage Condition
Store at 15-30° C
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FAQ
What is Bricarex Dx used for?
Bricarex Dx is a medicine that reduces inflammation and pain. It's used to treat aches and pains, as well as problems with joints, muscles and bones. These include: rheumatoid arthritis, osteoarthritis and gout.
What are side effects of Bricarex Dx?
Upset stomach, nausea, heartburn, diarrhea, constipation, gas, headache, drowsiness, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. This medication may raise your blood pressure.
Is Bricarex Dx stronger than tramadol?
Bricarex Dx provides effective and better analgesia in acute post operative pain than tramadol. Also, tramadol requires more frequent administration than Bricarex Dx.
Is Bricarex Dx a muscle relaxer?
Bricarex Dx is used to relieve pain and swelling (inflammation) from various mild to moderate painful conditions. It is used to treat muscle aches, backaches, dental pain, menstrual cramps, and sports injuries. It also reduces pain, swelling, and joint stiffness caused by arthritis.
What drugs interact with Bricarex Dx?
Serious Interactions of Bricarex Dx include:
- apixaban
- benazepril
- captopril
- enalapril
- fosinopril
- ketorolac
- ketorolac intranasal
- lisinopril
- methotrexate
- moexipril
- pemetrexed
- perindopril
- pirfenidone
- quinapril
- ramipril
- tacrolimus
- trandolapril
What is Bricarex Dx?
Bricarex Dx (Diclofenac) is indicated for treatment of primary dysmenorrhea, for relief of mild to moderate pain, for relief of the signs and symptoms of osteoarthritis, for relief of the signs and symptoms of rheumatoid arthritis, for relief of symptoms of ankylosing spondylitis and for relief of acute migraine symptoms. Bricarex Dx has analgesic, anti-inflammatory, and antipyretic properties.
Is Bricarex Dx an antibiotic?
Bricarex Dx has exhibited profound antibacterial effect against both gram-positive and gram-negative bacteria. It has also shown synergism with other antibiotics. These studies have suggested Bricarex Dx as a potent non-antibiotic antibacterial agent.
Is Bricarex Dx safe to take?
For most people, taking Bricarex Dx is safe. However, if you have high blood pressure, high cholesterol, diabetes, your kidneys do not work very well or you smoke, you should check with your healthcare professional that this medicine is appropriate.
Is Bricarex Dx a narcotic?
No, Bricarex Dx is a non-steroidal anti inflammatory (NSAID) drug and in no way related to narcotics.
What happens if I drink on Bricarex Dx?
Do not drink alcohol while taking Bricarex Dx. Alcohol can increase your risk of stomach bleeding caused by Bricarex Dx. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Can Bricarex Dx treat infection?
The analgesic and anti-inflammatory properties of aspirin and Bricarex Dx might represent an additional advantage for their use in the management of infections with Candida albicans.
How is Bricarex Dx injection given?
Intramuscularly, deeply. The product is used for treatment of acute conditions or relief of chronic disease exacerbation. Single dose for adults is 75 mg (one ampoule). If necessary, repeated injection is possible, but not earlier than in 12 hours.
How long can I take Bricarex Dx?
When used for severe or continuing arthritis, this medicine must be taken every day as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or longer may pass before you begin to feel better.
Is Bricarex Dx safe during pregnancy?
Use of Bricarex Dx during pregnancy is not advised unless prescribed by a doctor, especially if you are 30 or more weeks pregnant.
What is the side effect of Bricarex Dx in pregnancy?
Bricarex Dx may cause miscarriage (pregnancy loss), serious bleeding, or premature birth (baby is born too early) if taken during pregnancy.
Is Bricarex Dx safe during breastfeeding?
Bricarex Dx is not generally recommended in pregnancy or while breastfeeding. This is because diclofenac has been linked with a small risk of problems for your unborn baby if you take it in early or late pregnancy.
