Brinzolamid HEXAL

Brinzolamid HEXAL Uses, Dosage, Side Effects, Food Interaction and all others data.

Brinzolamid HEXAL is a carbonic anhydrase II (CA-II) inhibitor that inhibits aqueous humor production to reduce elevated intraocular pressure.

Used in the treatment of glaucoma, brinzolamide inhibits aqueous humor formation and reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. Brinzolamid HEXAL can decrease intraocular pressure by approximately 16-19% in patients with elevated intraocular pressure.

Trade Name Brinzolamid HEXAL
Generic Brinzolamide
Brinzolamide Other Names Brinzolamida, Brinzolamide
Type
Formula C12H21N3O5S3
Weight Average: 383.507
Monoisotopic: 383.064332867
Protein binding

Approximately 60%.

Groups Approved
Therapeutic Class Drugs for miotics and glaucoma
Manufacturer
Available Country Germany
Last Updated: September 19, 2023 at 7:00 am
Brinzolamid HEXAL
Brinzolamid HEXAL

Uses

used for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Brinzolamid HEXAL is also used to associated treatment for these conditions: Increased Intra Ocular Pressure (IOP), Ocular Hypertension

How Brinzolamid HEXAL works

Brinzolamid HEXAL is a highly specific inhibitor of CA-II, which is the main CA isoenzyme involved in the secretion of aqueous humor. Inhibition of CA in the ciliary process of the eye slows the formation of bicarbonate, and reduces sodium and fluid transport. This results in a reduction in the rate of aqueous humor secretion and the intraocular pressure. Brinzolamid HEXAL is absorbed systemically following topical ocular administration. Since it has a high affinity for CA-II, brinzolamide binds extensively to red blood cells, where CA-II is primarily found. As sufficient CA-II activity remains, adverse effects resulting from the systemic inhibition of CA by brinzolamide are not observed. The metabolite N-desethyl brinzolamide is also formed. This metabolite binds to CA and accumulates in red blood cells as well. In the presence of brinzolamide, the metabolite binds mainly to carbonic anhydrase I (CA-I).

Dosage

Brinzolamid HEXAL dosage

Instill 1 drop in the affected eye(s) 2-3 times daily. Zolamid may be used concomitantly with other topical ophthalmic drug to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.

Side Effects

Reported side effects are blurred vision and bitter, sour or unusual taste. Other side effects are blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus and rhinitis.

Precaution

The concomitant administration of Brinzolamid HEXAL 1% ophthalmic suspension and oral carbonic anhydrase inhibitor is not recommended due to no additional benefits.If hypersensitivity reaction occurs after instillation patients should be advised to discontinue the use of Brinzolamid HEXAL and consult with physicians.

Interaction

In patients treated with oral carbonic anhydrase inhibitors, rare instances to drug interactions have occurred with high-dose salicylate therapy. Therefore, the potential for such drug interactions should be considered in patients receiving Brinzolamid HEXAL.

Food Interaction

No interactions found.

Elimination Route

Absorbed into systemic circulation following topical ocular application

Half Life

111 days

Pregnancy & Breastfeeding use

Pregnancy Category C.No adequate and well-controlled studies are established in pregnant women. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

It is not known whether Brinzolamid HEXAL is secreted in human milk or not. Caution should be exercised when Brinzolamid HEXAL is administered to a nursing mother.Pediatric Use:Safety and effectiveness are not established in Pediatric patients.

Contraindication

It is contraindicated in patients who are hypersensitive to any component of this product.

Acute Overdose

Although no human data are available, electrolyte imbalance, development of an acidosis state, and possible nervous system effects may occur following oral administration of an overdose. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.

Interaction with other Medicine

In patients treated with oral carbonic anhydrase inhibitors, rare instances to drug interactions have occurred with high-dose salicylate therapy.

Storage Condition

- Store in a cool, dry place and protected from light.- Keep out of the reach of children.- Discard the container 4 weeks after opening.- Shake well before using.

Innovators Monograph

You find simplified version here Brinzolamid HEXAL

Brinzolamid HEXAL contains Brinzolamide see full prescribing information from innovator Brinzolamid HEXAL Monograph, Brinzolamid HEXAL MSDS, Brinzolamid HEXAL FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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