Brocof
Brocof Uses, Dosage, Side Effects, Food Interaction and all others data.
Brocof is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Brocof stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Brocof stimulates production of phospholipids of surfactant by alveolar cells. Brocof has anti-inflammatory properties. In patients with COPD, it improves airway patency. Beside these, Brocof also exhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation.
| Trade Name | Brocof |
| Generic | Ambroxol |
| Ambroxol Other Names | Ambroxol, Ambroxolum, Bisolvon metabolite vIII, Bromhexine metabolite vIII, Bromhexine-metabolite vIII |
| Type | |
| Formula | C13H18Br2N2O |
| Weight | Average: 378.108 Monoisotopic: 375.978589 |
| Protein binding | Approximately 90% |
| Groups | Approved, Investigational |
| Therapeutic Class | Cough expectorants & mucolytics |
| Manufacturer | |
| Available Country | Philippines |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
- • Acute and chronic diseases of respiratory tracts associated with viscid mucus including acute and chronic bronchitis
- • Productive cough
- • Inflammatory diseases of Rhinopharyngeal tract (e.g. Laryngitis, Pharyngitis, Sinusitis and Rhinitis) associated with viscid mucus
- • Asthmatic bronchitis, Bronchial asthma with difficult departure of mucus
- • Bronchiectasis
- • Chronic pneumonia.
Brocof is also used to associated treatment for these conditions: Airway secretion clearance therapy
How Brocof works
Brocof is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Brocof has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.
Dosage
Brocof dosage
Average daily dose (preferably after meal):Pediatric Drops:
- 0-6 months: 0.5 ml 2 times a day
- 6-12 months: 1 ml 2 times a day
- 1-2 years: 1.25 ml 2 times a day
Syrup:
- 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
- 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
- 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.
Sustained release capsule:
- Adult and children over 12 years old: 1 capsule once daily
Specific application features: Brocof may be prescribed to patients suffering from diabetes mellitus.
Side Effects
Gastrointestinal side-effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema may occur.
Precaution
Brocof should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Interaction
Brocof has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Brocof should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Brocof, might not be expectorated.
Elimination Route
Rapid and almost complete.
Half Life
7-12 hours
Pregnancy & Breastfeeding use
Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Brocof. However, it is advised not to use during pregnancy, especially in the 1st trimester.
Lactation: Safety during lactation has not been established.
Contraindication
Contraindicated in known hypersensitivity to Brocof or Bromhexine.
Interaction with other Medicine
Brocof has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Brocof should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Brocof, might not be expectorated.
Innovators Monograph
You find simplified version here Brocof
Brocof contains Ambroxol see full prescribing information from innovator Brocof Monograph, Brocof MSDS, Brocof FDA label
FAQ
What is Brocof used for?
Brocof is used for conditions where there are a lot of thick mucus in the airway passages. Brocof belongs to a group of medications called mucolytics.It is used in the treatment of respiratory diseases associated with viscid or excessive mucus.
How safe is Brocof?
Brocof is a safe and well-tolerated treatment of bronchopulmonary diseases with a well-balanced and favorable benefit-risk profile.
How does Brocof work?
Brocof works by thinning down the mucus in the airway passages, thus making the mucus less sticky and it also facilitates the removal of the mucus from the airways.
What are the common side effects of Brocof?
Common side effects of Brocof are include:
- Nausea
- Vomiting
- Diarrhea
- Gastrointestinal side effects
- Skin rash
- itching
- Infections
- Allergies
- Upset stomach
- Dizziness
- Weakness
- Dry mouth
- Indigestion
- Numbness in throat
- Numbness in mouth
- Taste disturbances
Is Brocof safe during pregnancy?
Brocof is not advisable to taken during the first trimester of pregnancy. Please seek your doctor's or pharmacist's advice before using Brocof if you are pregnant.
Is Brocof safe during breastfeeding?
As Brocof is excreted in breast milk, it is not recommended to be taken while breastfeeding. Please seek your doctor's or pharmacist's advice before using this medication if you breastfeeding.
Can I drink alcohol with Brocof?
No. Even though you can readily find products containing dextromethorphan OTC, these medicines can be very dangerous when mixed with alcohol.
Can I drive after taking Brocof?
It is advisable not to drive any motor vehicle or operate heavy machinery as increased drowsiness and dizziness can occur after taking.
When should be taken of Brocof?
The recommended dose is 30mg to be taken three times a day.
How long does Brocof take to work?
When administered orally onset of action occurs after about 30 minutes.
How long should I take Brocof?
Brocof was administered intramuscularly daily for 6-10 days at the following dosages: 1.7 mg/kg (children <2 years), 1.6 mg/kg (children 2-5 years) and 1.2 mg/kg (6-10 years).
What happens if I miss a dose?
If you miss a dose, use this drug as soon as you find it. Skip the missed dose and restart your dosing schedule if it is close to the time of your next dose. Do not use an additional dose in order to make up for the missing dose.
What happens if I overdose of Brocof?
Do not take more than the dosage given. Your symptoms will not be changed by taking more medication; they can instead cause poisoning or severe side effects. If you believe that you or someone else might have overdosed on Brocof Hydrochloride Syrup, please go to the nearest hospital or nursing home emergency room.
Who should not take Brocof?
If you have serious gastric ulceration, liver or kidney issues, notify your healthcare professionals. If you have a confirmed history of an allergy to Brocof, or any of the other ingredients mentioned in the medicine, this drug should be avoided.
Can I take Brocof on an empty stomach?
The tablets may be taken with or without food.
Is Brocof for dry cough?
Brocof is more effective in productive cough treatment associated with the formation of sticky and thick mucus in the airway passages and is difficult to clear.Brocof reduces its thickness and makes its removal easier from the airways passage.
Is Brocof good for itchy throat?
Brocof has a beneficial pain-relieving effect in patients with acute sore throat, superior to that achieved by sucking a placebo lozenge.
Is Brocof a steroid?
No, it is not an antibiotic or steroid; it belongs to a class of medicines called Expectorants or Mucolytics. It has no known effect against infections.
How often should I take Brocof?
The recommended dose for adults is 1 tablet 3 times daily. For better effect, the patient may administer 2 tablets 2 times daily. The tablets should be taken with liquid.
Is Brocof an antibiotic?
Brocof is a mucolytic agent used in the treatment of respiratory diseases.
