BufferGel
BufferGel Uses, Dosage, Side Effects, Food Interaction and all others data.
BufferGel is a highly carboxylated polymer composed of lightly cross-linked polyacrylic acid with a broad-spectrum mechanism based on acidification of pathogens. It was under development by ReProtect LLC. It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies. The compound, known as BufferGel, was in advanced clinical trials for its ability to prevent pregnancy, but was discontinued.
| Trade Name | BufferGel |
| Generic | Carbopol 974P |
| Carbopol 974P Other Names | Carbomer 974 (P), Carbomer 974P, Carbomer homopolymer type B, Carbomer-974P, Carbopol polymer |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
BufferGel is a polymer used as a lacrimal substitute to treat symptoms associated with dry eyes.
Investigated for use/treatment in contraception and HIV prevention.
BufferGel is also used to associated treatment for these conditions: Dry Eyes, Inflammation caused by corticosteroid-responsive dermatoses, Pruritus caused by corticosteroid-responsive dermatoses
How BufferGel works
BufferGel is a microbicidal spermicide that provides sufficient buffering activity to maintain the mild, protective acidity of the vagina in the presence of semen. Sperm are acid-sensitive, so to assure fertility, semen provides a powerful alkalinizing action that abolishes the protective acidity of the vagina for several hours after intercourse. This alkalinizing action of semen also enables acid-sensitive sexually transmitted diseases (STD) pathogens to transmit infection. By blocking this action of semen, BufferGel prevents unwanted pregnancy, and shows promise for prevention of STDs, including HIV/AIDS.
Innovators Monograph
You find simplified version here BufferGel
