Butylscopolamine
Butylscopolamine Uses, Dosage, Side Effects, Food Interaction and all others data.
Butylscopolamine is a peripherally acting antimuscarinic, anticholinergic agent. It is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not a pain medication in the normal sense, since it does not directly affect pain, but rather works to prevent painful cramps and spasms from occurring. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.
Scopolamine butylbromide is a muscarinic antagonist which acts to prevent acetylcholine-stimulated contraction of smooth muscle in the gastrointestinal tract .
| Trade Name | Butylscopolamine |
| Generic | Butylscopolamine |
| Butylscopolamine Other Names | butilescopolamina, N-butylscopolammonium, N-butylscopolammonium ion |
| Type | |
| Formula | C21H30NO4 |
| Weight | Average: 360.473 Monoisotopic: 360.21693487 |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Butylscopolamine is an antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
Used to treat abdmoninal cramping and pain .
Butylscopolamine is also used to associated treatment for these conditions: Gastrointestinal spastic and hypermotility disorders, Infantile Hypertrophic Pyloric Stenosis, Menstrual Distress (Dysmenorrhea), Muscle Spasms, Pain, Primary Dysmenorrhoea, Stiffness of the Urinary Tract, Acute biliary spasm, Acute gastrointestinal spasms, Acute genitourinary spasms, Genitourinary smooth muscle spasm, Analgesia, Smooth muscle relaxation prior to radiological procedures
How Butylscopolamine works
Scopolamine butylbromide binds to muscarinic M3 receptors in the gastrointestinal tract . This prevents acetycholine from binding to and activating the receptors which would result in contraction of the smooth muscle. The inhibition of contraction reduces spasms and their related pain during abdominal cramping.
Food Interaction
No interactions found.Volume of Distribution
The volume of distribution is 128 liters .
Elimination Route
Scopolamine butylbromide has extremely low oral bioavailability with only 0.25-0.82% reaching systemic circulation . Peak plasma concentration is reached 0.25-2 hours. Scopolamine butylbromide does not cross the blood brain barrier.
Half Life
The half life of elimination is 1-5 hours .
Clearance
Total clearace is 1.2 liters per minute .
Elimination Route
Mainly eliminated in the feces (69.7%) with very little in the urine (4.4%) . Only 2.8% is eliminated via the bile owing to scopolamine butylbromide's poor absorption.
Innovators Monograph
You find simplified version here Butylscopolamine
