Cal Tab
Cal Tab Uses, Dosage, Side Effects, Food Interaction and all others data.
The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Calcidiol is the precursor of vitamin D3. Vitamin D3 is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of vitamin A. The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma.
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.
| Trade Name | Cal Tab |
| Generic | Calcifediol + Calcium |
| Weight | 200iu, 600mg |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Millinium Pharmaceutical Company |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Calcifediol is an active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.
Calcium is a mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency.
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
Cal Tab is also used to associated treatment for these conditions: Secondary Hyperparathyroidism (SHPT)Calcium Deficiency, Deficiency, Vitamin D, Osteodystrophy, Osteomalacia, Osteoporosis, Chronic Hypocalcemia, Chronic Hypocalcemia caused by anticonvulsant medications, Care of the Joint, Mineral supplementation, Nutritional supplementation
How Cal Tab works
Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitriol, the active form of vitamin D3. Calcitriol binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein.
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.
Toxicity
Bone pain, constipation (especially in children or adolescents), diarrhea, drowsiness, dryness of mouth; headache (continuing), increased thirst, increase in frequency of urination, especially at night, or in amount of urine, irregular heartbeat, itching skin, loss of appetite, metallic taste, muscle pain, nausea or vomiting (especially in children or adolescents), unusual tiredness or weakness.
Elimination Route
Readily absorbed.
Half Life
288 hours
Elimination Route
The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.
Innovators Monograph
You find simplified version here Cal Tab
FAQ
What is Cal Tab used for?
Cal Tab is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat moderately severe pain and inflammation, usually after surgery. Cal Tab works by blocking the production of prostaglandins, compounds that cause pain, fever, and inflammation.
Why Cal Tab use only for 5 days?
Parenteral Cal Tab (ketorolac tromethamine) has been effectively used to treat postoperative pain for several decades. However, its use is limited to a 5-day treatment duration due to an increased risk of gastrointestinal (GI) bleeding.
Is Cal Tab stronger than ibuprofen?
Intravenous Cal Tab given at the conclusion of surgery was more effective than either oral acetaminophen or oral ibuprofen given 30 to 45 minutes after strabismus surgery in controlling postoperative pain. Pain relief was achieved earlier by intravenous delivery than by oral agents.
Is Cal Tab stronger than tramadol?
A study in India compared Cal Tab to tramadol for post-op pain after maxillofacial surgery in 50 adults. Both drugs were given IM. Both drugs caused a significant decrease in pain, but tramadol resulted in better pain control than Cal Tab at every hour, and was better tolerated.
How long does it take for Cal Tab to kick in?
It starts working quickly (about 15 minutes after administration) and can last up to 6 hours. It's often prescribed for post-surgery pain and acute migraines, but also for chronic migraines when other treatments haven't worked.
Who should not take Cal Tab?
chronic kidney disease stage 4 (severe) chronic kidney disease stage 5 (failure) kidney disease with likely reduction in kidney function. aspirin exacerbated respiratory disease.
Is Cal Tab stronger than naproxen?
Cal Tab is not used for minor or chronic painful conditions. Other NSAIDs include naproxen (Aleve, Naprosyn) and ibuprofen (Advil, Motrin), but Cal Tab is better than other NSAIDs in reducing pain from both inflammatory and non-inflammatory causes.
Can I get addicted to Cal Tab?
Cal Tab is not addictive, but it's a very strong NSAID and can lead to serious side effects. You also shouldn't take it for long periods of time.
Does Cal Tab cause drowsiness?
Cal Tab may cause some people to become dizzy or drowsy. If either of these side effects occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert. Serious side effects can occur during treatment with this medicine.
Is Cal Tab good for back pain?
Based on comparable efficacy and a superior adverse event profile, Cal Tab was preferable to acetaminophen with codeine for the treatment of acute low back pain in the ED.
What is Cal Tab equivalent to?
Clinical evidence from other settings has shown that Cal Tab (ketorolac) and morphine are equivalent in relieving pain, but there is a distinct benefit favoring Cal Tab (ketorolac) in terms of side effects.
Is Cal Tab 10 mg a controlled substance?
Cal Tab is used in the treatment of postoperative pain; pain and belongs to the drug class Nonsteroidal anti-inflammatory drugs. Risk cannot be ruled out during pregnancy. Cal Tab 10 mg is not a controlled substance under the Controlled Substances Act (CSA).
Is Cal Tab anti-inflammatory?
Cal Tab, like other NSAIDs, has analgesic, anti-inflammatory, and antipyretic properties. Unlike morphine or meperidine, Cal Tab (ketorolac) does not bind to opioid receptors and is not a centrally acting agent. Administered intramuscularly, peak plasma levels are reached in 45 to 50 minutes.
Does Cal Tab work for pain?
Cal Tab (ketorolac tromethamine) is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat moderately severe pain and inflammation, usually after surgery. Cal Tab works by blocking the production of prostaglandins, compounds that cause pain, fever, and inflammation.
Does Cal Tab have a black box warning?
Cal Tab is contraindicated in patients currently receiving aspirin and/or NSAIDs because of cumulative risk of inducing serious NSAID-related side effects. Please see BLACK BOX WARNINGS for additional precautions.
Is Cal Tab the same as tramadol?
Cal Tab and tramadol belong to different drug classes. Cal Tab is a nonsteroidal anti-inflammatory drug (NSAID) and tramadol is a pain reliever (analgesic) that acts similar to narcotics.
What are the side effects of Cal Tab?
Side effects of Cal Tab include:
- Headache
- Drowsiness
- Indigestion
- Stomach or abdominal pain
- Nausea
- Diarrhea
- Dizziness
- Itching
- Swelling (edema)
- Increased blood urea nitrogen (BUN)
- Constipation
- Purpura
- Increased serum creatinine
- Drowsiness
- High blood pressure (hypertension)
What drugs does Cal Tab interact with?
Interaction reports for Cal Tab and the medicines listed below.
- Benadryl (diphenhydramine)
- Benadryl (diphenhydramine)
- Combivent (albuterol / ipratropium)
- Combivent (albuterol / ipratropium)
- Cymbalta (duloxetine)
- Cymbalta (duloxetine)
- Flexeril (cyclobenzaprine)
- Flexeril (cyclobenzaprine)
- Lyrica (pregabalin)
- Lyrica (pregabalin)
- Norco (acetaminophen / hydrocodone)
- Norco (acetaminophen / hydrocodone)
- Paracetamol (acetaminophen)
- Paracetamol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xanax (alprazolam)
Can I drink alcohol while taking Cal Tab?
Avoid drinking alcohol. It may increase your risk of stomach bleeding. Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms
Where do I inject Cal Tab?
Cal Tab is given by injection into a muscle or vein as directed by your doctor. It may be given as a one-time dose or given on a regular schedule. If given on a regular schedule, it is usually injected every 6 hours as needed, or as directed by your doctor. This drug must not be injected into the spine.
Is Cal Tab bad for heart?
Cal Tab can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
How many days in a row can take Cal Tab?
Minor upper gastrointestinal problems, such as dyspepsia, are common and may also occur at any time during NSAID therapy. The incidence and severity of gastrointestinal complications increases with increasing dose of, and duration of treatment with, Cal Tab. Do not use Cal Tab for more than five days.
Can I take Cal Tab and ibuprofen together?
Using Cal Tab together with ibuprofen is not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.
Can Cal Tab cause weight gain?
If you experience any of the following symptoms, stop using Cal Tab injection and call your doctor: unexplained weight gain; swelling of the hands, arms, feet, ankles, or lower legs; confusion; or seizures.
What does Cal Tab do for eyes?
Ophthalmic Cal Tab is used to treat itchy eyes caused by allergies. It also is used to treat swelling and redness (inflammation) that can occur after cataract surgery. Cal Tab is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs).
Can Cal Tab help with nerve pain?
Cal Tab is not commonly used to treat neuropathic pain, as NSAIDs have limited evidence in the management of neuropathic pain.
What are the benefits of Cal Tab?
This medication is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever. Cal Tab should not be used for mild or long-term painful conditions (such as arthritis).
Is Cal Tab a painkiller?
Cal Tab is a painkiller medicine.
Is it safe to use Cal Tab?
Cal Tab has side effects that can be very dangerous. The risk of having a serious side effect increases with the dose of Cal Tab and with the length of treatment. Therefore, Cal Tab should not be used for more than 5 days.
What medicine should not take with Cal Tab?
Do not take aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn) while you are taking Cal Tab. Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines.
What is Cal Tab?
Cal Tab is a non-steroidal anti-inflammatory drug (NSAID). It is used for a short while to treat moderate to severe pain, including pain after surgery. It should not be used for more than 5 days.
How long can I use Cal Tab eye drops?
Adults and children 3 years of age and older
- Use one drop in the affected eye(s) 4 times a day for up to 4 days after the surgery.
- Children younger than 3 years of age—Use and dose must be determined by your doctor.
How long should I use Cal Tab after cataract surgery?
For cataract surgery you will begin using the eye drops 1 day before surgery and continue for up to 2 weeks afterward. For corneal refractive surgery the usual dosage is 4 times daily for up to 4 days after surgery. Do not use Cal Tab ophthalmic while you are wearing contact lenses.
How long does Cal Tab stay in my body?
The average elimination half-life of Cal Tab is 5 to 6 hours. This is the time it takes for your body to reduce the plasma levels by half.
