Calak

Uses

Glycerol helps lubricating in sexual intercourse specially for post menopausal women to reduce irritation, for lubrication during vaginal examinations, endoscopy, catheterization for gloves and instruments. It is also used to treat or prevent dry skin.

Sodium citrate is an ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.

Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine .

Zinc Oxide helps to To treat or prevent skin irritations (e.g., burns, bed sore, cuts, poison ivy, diaper rash). Protects chafed skin due to diaper rash and helps seal out wetness.

Calak is also used to associated treatment for these conditions: Acidosis, Allergic cough, Allergies, Asthma, Asthma Chronic, Cough, Common Cold, Cough, Coughing caused by Bronchitis, Dehydration, Gouty Arthritis, Heartburn, Metabolic Acidosis, Phlegm, Airway secretion clearance therapy, Oral rehydration therapy, Plasmapheresis, Urine alkalinization therapy, Fluid and electrolyte maintenance therapy, Irrigation during surgical procedures, Irrigation of the ocular surface therapyAcute Wounds, Burns first degree, Burns second degree, Dermatitis, Eczematous, Diaper Rash, Herpes Labialis, Injuries to the Nipple (Fissures and Cracks) Resulting Breastfeeding, Intertrigo, Pain, Pruritus, Sensitive Skin, Skin Irritation, Skin candida, Sunburn, Wounds, Chafing, Damaged skin, Dry, cracked skin, Facial rash, Heat rash, Superficial Wounds, Watery skin lesions, Astringent, Nutritional supplementation

How Calak works

Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X . This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate . Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine . It also acts as a diuretic and increases the urinary excretion of calcium.

It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.

Dosage

Calak dosage

Apply as needed.

Apply thin layer topically every 8 hourly. Change wet and soiled diapers, promptly cleans the diaper area, allow to dry and apply ointment liberally as often as necessary, with each diaper change, especially at bedtime or any time when exposure to wet diapers may be prolonged.

Side Effects

Usually well tolerated. Extremely low frequency of hypersensitivity reaction.

Toxicity

Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium .

Acute oral toxicity (LD50): 7950 mg/kg [Mouse].

Precaution

Glycerol is for external use only. When using this product do not get into eyes. Do not use on deep or puncture wounds, animal bites & serious burns.

For external use only. Avoid contact with the eyes. Stop use and ask a doctor if condition worsens or does not improve within 7 days. Keep out of the reach of children. If swallowed, get medical help or contact a poison control center right away

Volume of Distribution

19-39L .

Intended for local use only, no systemic absorption.

Elimination Route

Tmax of 98-130min .

No significant percutaneous absorption from topically applied zinc oxide.

Half Life

18-54 min

Intended for local use only, no systemic absorption.

Clearance

Total clearance of 313-1107mL/min .

Intended for local use only, no systemic absorption.

Elimination Route

Largely eliminated through hepatic metabolism with very little cleared by the kidneys .

Intended for local use only, no systemic absorption.

Pregnancy & Breastfeeding use

This medication should be used with precautions only if clearly needed during pregnancy or while breast feeding

Contraindication

Usually well tolerated. People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it.

Known hypersensitivity to any component of the preparation

Acute Overdose

No overdose related problem is yet reported.

Storage Condition

Store in a cool & dry place, protected from light. Keep out of reach of children.

keep in a cool and dry place, away from light.

Innovators Monograph

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