Calciferol Oily Solution Lennon
Calciferol Oily Solution Lennon Uses, Dosage, Side Effects, Food Interaction and all others data.
A vitamin D that can be regarded as a reduction product of vitamin D2.
Calciferol Oily Solution Lennon is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1, 25-dihydroxyvitamin D. Calciferol Oily Solution Lennon is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. Calciferol Oily Solution Lennon also increases renal phosphate excretion.
| Trade Name | Calciferol Oily Solution Lennon |
| Availability | Discontinued |
| Generic | Dihydrotachysterol |
| Dihydrotachysterol Other Names | Anti-tetany substance 10, Dihidrotaquisterol, Dihydrotachysterol, Dihydrotachysterolum |
| Related Drugs | Prolia, hydrochlorothiazide, alendronate, calcitriol, calcitonin, Fosamax, ergocalciferol, calcium carbonate, Caltrate |
| Type | |
| Formula | C28H46O |
| Weight | Average: 398.6642 Monoisotopic: 398.354866094 |
| Protein binding | >99% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | South Africa |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Calciferol Oily Solution Lennon is a synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
Calciferol Oily Solution Lennon is also used to associated treatment for these conditions: Hypoparathyroidism, Pseudohypoparathyroidism
How Calciferol Oily Solution Lennon works
Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor)stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. This stimulates intestinal calcium absorption and increases renal phosphate excretion. These are functions that are normally carried out by the parathyroid hormone.
Toxicity
Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.
Food Interaction
No interactions found.Calciferol Oily Solution Lennon Drug Interaction
Unknown: anastrozole, anastrozole, hydroxyzine, hydroxyzine, diphenhydramine, diphenhydramine, glatiramer, glatiramer, liothyronine, liothyronine, methylprednisolone, methylprednisolone, benzoyl peroxide / clindamycin topical, benzoyl peroxide / clindamycin topical, dicloxacillin, dicloxacillin, gabapentin, gabapentin, chorionic gonadotropin , chorionic gonadotropin
Calciferol Oily Solution Lennon Disease Interaction
Major: arrhythmia, electrolyte imbalance, renal dysfunctionModerate: hepatobiliary dysfunction
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