Calm P

Calm P Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name Calm P
Availability Prescription only
Generic Hydroxyprogesterone
Hydroxyprogesterone Other Names 17-hydroxyprogesterone, Hidroxiprogesterona, Hydroxyprogesterone, Hydroxyprogesteronum
Related Drugs nifedipine, progesterone, terbutaline, Prometrium, Crinone
Type
Formula C21H30O3
Weight Average: 330.4611
Monoisotopic: 330.219494826
Groups Experimental
Therapeutic Class
Manufacturer
Available Country Australia
Last Updated: September 19, 2023 at 7:00 am
Calm P
Calm P

Food Interaction

[Moderate] MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme.

The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.

Because grapefruit juice inhibits primarily intestinal rather than hepatic CYP450 3A4, the magnitude of interaction is greatest for those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability).

In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands.

Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition.

Pharmacokinetic interactions involving grapefruit juice are also subject to a high degree of interpatient variability, thus the extent to which a given patient may be affected is difficult to predict.

MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4.

Grapefruit and grapefruit juice should be avoided if an interaction is suspected.

Orange juice is not expected to interact with these drugs.

Calm P Cholesterol interaction

[Moderate] Some progestogenic agents may elevate plasma LDL levels and

Patients with preexisting hyperlipidemia may require closer monitoring during progestogen therapy, and adjustments made accordingly in their lipid-lowering regimen.

Calm P Hypertension interaction

[Moderate] Estrogens and progestogens may cause fluid retention, particularly when given in high dosages or for prolonged periods.

Therapy with these agents should be administered cautiously in patients who have preexisting problems with excess fluid.

In addition, patients with conditions that may be adversely affected by fluid accumulation, such as asthma, epilepsy, migraine, and cardiovascular or renal dysfunction, should be observed for exacerbation of their condition during estrogen and

Innovators Monograph

You find simplified version here Calm P

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000012
http://classyfire.wishartlab.com/tax_nodes/C0000258
http://classyfire.wishartlab.com/tax_nodes/C0003569
http://classyfire.wishartlab.com/tax_nodes/C0001468
http://classyfire.wishartlab.com/tax_nodes/C0003058
http://classyfire.wishartlab.com/tax_nodes/C0002974
http://classyfire.wishartlab.com/tax_nodes/C0003236
http://classyfire.wishartlab.com/tax_nodes/C0002978
http://classyfire.wishartlab.com/tax_nodes/C0004325
http://classyfire.wishartlab.com/tax_nodes/C0001670
http://classyfire.wishartlab.com/tax_nodes/C0002912
http://classyfire.wishartlab.com/tax_nodes/C0001292
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17252
http://www.genome.jp/dbget-bin/www_bget?cpd:C01176
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMST02030161
http://www.hmdb.ca/metabolites/HMDB0000374
http://www.genome.jp/dbget-bin/www_bget?cpd:C01176
https://www.chemspider.com/Chemical-Structure.6002.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423511
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=5542
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=17252
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1062
https://zinc.docking.org/substances/ZINC000005434436
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/3QZ
https://en.wikipedia.org/wiki/17%CE%B1-Hydroxyprogesterone
*** Taking medicines without doctor's advice can cause long-term problems.
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