Cambinol
Cambinol Uses, Dosage, Side Effects, Food Interaction and all others data.
Cambinol is a beta-naphtol derivative that inhibits NAD-dependant deacetylases to reduce cell survival under stress. This activity is currently being investigated for its use as a cancer treatment.
| Trade Name | Cambinol |
| Generic | Cambinol |
| Type | |
| Formula | C21H16N2O2S |
| Weight | Average: 360.43 Monoisotopic: 360.093248937 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cambinol is an investigational histone deacetylase inhibitor that may have future use in cancer treatment.
How Cambinol works
Cambinol inhibits the NAD-dependant deacetylases SIRT1 and SIRT2, members of a protein family known as sirtuins.
Inhibiting SIRT1 and SIRT2 while cells are under stress increases acetylation of p53, Ku70, and Foxo3a. This inhibition sensitizes cells to the action of drugs like etoposide and paclitaxel, not just other drugs that damage DNA. Although the mechanism of this sensitizing is not defined, it is not dependent on p53, Ku70, or Foxo3a. The independent mechanism suggests the existence of more molecular targets.
Cambinol is noncompetitive against NAD and competitive against H-4 peptide, substrates of SIRT2. Inhibiting SIRT2 increases the acetylation of tubulin.
Cambinol also increases the acetylation of BCL6, a protein necessary for oncogenesis.
Cambinol is also a weak inhibitor of SIRT5.
Innovators Monograph
You find simplified version here Cambinol
