Campath
Campath Uses, Dosage, Side Effects, Food Interaction and all others data.
Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.
Campath is used to treat leukemia by exploiting antibody mediated lysis of CD52 presenting cells. The CD52 antigen is a cell surface protein found on essentially all B and T lymphocytes, a majority of monocytes, macrophages and most granulocytes. The CD52 antigen is not present on erythrocytes or hematopoetic stem cells. In leukemia there is an excess of B and T cells, so Campath permits selective reduction of lymphocyte populations.
| Trade Name | Campath |
| Availability | Prescription only |
| Generic | Alemtuzumab |
| Alemtuzumab Other Names | Alemtuzumab |
| Related Drugs | Gilenya, Tysabri, Venclexta, Vumerity, rituximab, Rituxan, cyclophosphamide, Copaxone, Imbruvica, Tecfidera |
| Weight | 10mg/ml, 30mg/ml, |
| Type | Intravenous solution |
| Formula | C6468H10066N1732O2005S40 |
| Weight | 145453.8 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Campath is a monoclonal anti-CD52 antibody used in the treatment of B-cell chronic lymphocytic leukemia and relapsing forms of multiple sclerosis.
Campath (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia.
Campath is also used to associated treatment for these conditions: Autoimmune Hemolytic Anemia, B-Cell Chronic Lymphocytic Leukemia, Graft Versus Host Disease (GVHD), Kidney Transplant Rejection, Relapsing Remitting Multiple Sclerosis (RRMS), T-Cell Prolymphocytic Leukemia, Conditioning regimens for allogeneic stem cell transplantation therapy
How Campath works
Campath binds to the CD52 antigen present on most B and T lymphocytes. This binding leads to antibody-dependent lysis of leukemic cells.
Food Interaction
No interactions found.Campath Drug Interaction
Major: teriflunomide, teriflunomideModerate: aspirin, aspirin, dimethyl fumarate, dimethyl fumarateUnknown: acetaminophen, acetaminophen, charcoal, charcoal, alprazolam, alprazolam, dalfampridine, dalfampridine, pseudoephedrine / triprolidine, pseudoephedrine / triprolidine, interferon beta-1a, interferon beta-1a, sodium iodide, sodium iodide
Campath Disease Interaction
Major: cytopeniasModerate: cardiac/pulmonary disease, infections
Volume of Distribution
- 0.18 L/kg
Half Life
~288 hrs
Innovators Monograph
You find simplified version here Campath
