Capreomycin

Capreomycin Uses, Dosage, Side Effects, Food Interaction and all others data.

Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.

Capreomycin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB).

Trade Name Capreomycin
Availability Discontinued
Generic Capreomycin
Capreomycin Other Names Capreomicina, Capreomycin
Related Drugs ciprofloxacin, levofloxacin, Levaquin, rifampin
Weight 1g,
Type Injection, Intramuscular Powder For Injection
Formula C50H88N28O15
Weight Average: 1321.4123
Monoisotopic: 1320.698394286
Groups Approved
Therapeutic Class
Manufacturer Sanjeevani Biotech Private Limited
Available Country India, United States,
Last Updated: September 19, 2023 at 7:00 am
Capreomycin
Capreomycin

Uses

Capreomycin is an aminoglycoside antibiotic used as an adjunct drug in tuberculosis.

Used in the treatment of tuberculosis in combination with other drugs.

Capreomycin is also used to associated treatment for these conditions: Tuberculosis (TB)

How Capreomycin works

Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Capreomycin also binds to components in the bacterial cell which result in the production of abnormal proteins. These proteins are necessary for the bacteria's survival. Therefore the production of these abnormal proteins is ultimately fatal to the bacteria.

Toxicity

Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD50) in mice was 514 mg/kg.

Food Interaction

No interactions found.

Elimination Route

Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally.

Elimination Route

When a 1–g dose of capreomycin was given intramuscularly to normal volunteers, 52% was excreted in the urine within 12 hours.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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