Carbonyldiamide
Carbonyldiamide Uses, Dosage, Side Effects, Food Interaction and all others data.
Carbonyldiamide is an osmotic diuretic similar to mannitol but more irritant. It induces diuresis by increasing osmotic pressure of the glomerular filtrate and increasing excretion of sodium, potassium and chloride ions. Its osmotic effect also draws water from cells e.g. brain, CSF and anterior chamber of the eye, thereby decreasing intracranial or intraocular pressure. Unlike mannitol, urea penetrates the eye and causes a rebound increase in intraocular pressure if the plasma concentration of the drug is less than that in the vitreous humour. Applied topically, urea promotes hydration of keratin and mild keratolysis in dry skin. It increases water uptake by the stratum corneum and has an antipruritic effect.
As a humectant, urea draws water into the striatum corneum.
| Trade Name | Carbonyldiamide |
| Availability | Rx and/or OTC |
| Generic | Urea |
| Urea Other Names | Carbamide, Carbonyldiamide, Harnstoff, Karbamid, Urea, Urée |
| Related Drugs | tolvaptan, Samsca, sodium acetate, ure-Na |
| Type | |
| Formula | CH4N2O |
| Weight | Average: 60.0553 Monoisotopic: 60.03236276 |
| Groups | Approved, Investigational |
| Therapeutic Class | Topical urea preparations |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Carbonyldiamide 25% cream is used for the treatment of dry, cracked skin and hyperkeratosis on the soles of the feet including the heels. Suitable for general and diabetic foot care.
Carbonyldiamide is also used to associated treatment for these conditions: Dermatitis, Dermatitis, Contact, Dermatitis, Eczematous, Dry Eyes, Dry Skin, Dry Skin; Eczema, Eczema, Dyshidrotic, Eye pruritus, Helicobacter Pylori Infection, Insect Bites, Lichen Planus (LP), Neurodermatitis, Nummular Dermatitis, Psoriasis, Seborrheic Dermatitis, Sunburn, Allergic skin manifestations, Anal eczema, Calluses, Moisturizing
Dosage
Carbonyldiamide dosage
Apply a small amount twice daily to the skin after washing or bathing.
In extreme cases, before bed you may choose to cover the feet with plastic wrap and then put socks over the plastic wrap to increase the hydration rate.
Recommended for use on adults and children over 12 years.
After use, wear sandals or slippers to avoid staining carpets.
Side Effects
May irritate inflamed skin or exudative lesions. Transient stinging may occur in deep cracks. Discontinue use if local irritation or rash occurs during use.
Food Interaction
No interactions found.Carbonyldiamide Drug Interaction
Moderate: glycerin, escitalopramUnknown: aspirin, aspirin, sulfamethoxazole / trimethoprim, ubiquinone, copper gluconate, meperidine, omega-3 polyunsaturated fatty acids, pregabalin, metoprolol, acetaminophen / hydrocodone, bioflavonoids, montelukast, levothyroxine, cyanocobalamin, ascorbic acid, ergocalciferol, cholecalciferol, cetirizine
Carbonyldiamide Disease Interaction
Pregnancy & Breastfeeding use
Carbonyldiamide cream can be used during pregnancy and lactation.
Contraindication
For use only on the soles of the feet and heels unless otherwise directed by the prescriber. Pregnant women should consult their Healthcare Professional before use. For External Use Only. Avoid contact with eyes. Keep out of reach of children. Always replace cap after use. Do not use if tube seal is broken or appears tampered with.
Storage Condition
Store between 10° – 30° C in a dry place. Keep lid tightly closed.
Innovators Monograph
You find simplified version here Carbonyldiamide
FAQ
What is Carbonyldiamide used for?
Carbonyldiamide is used to treat dry skin conditions (e.g., eczema, psoriasis, corns, callus) and some nail problems (e.g., ingrown nails). It may also be used to help remove dead tissue in some wounds to help wound healing.
How safe urea is?
Carbonyldiamide can be toxic if fed at too high a level so it's important not to overfeed and mixing thoroughly is vital. The level of Carbonyldiamide required is low, a maximum level of 0.7% of the overall feed dry matter is advised.
What are the common side effect of Carbonyldiamide?
Common side effects of Carbonyldiamide include:
- Local irritation (burning, itching, redness)
- Temporary stinging.
- Rash.
What does Carbonyldiamide do to the body?
Carbonyldiamide is known as a keratolytic agent. This means it breaks down the protein keratin in the outer layer of your skin. Carbonyldiamide can help reduce dead skin buildup and get rid of flaking or scaling skin.
Is Carbonyldiamide safe during pregnancy?
It is not known whether urea topical will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.
Is Carbonyldiamide safe during breastfeeding?
It is not known whether urea topical passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.
Can I drink alcohol with Carbonyldiamide?
The presence of Carbonyldiamide decreases the hydrophobic effect of a monovalent alcohol, strongly at low temperatures, to a lesser degree at high temperatures . Consequently, urea hinders the interhydrophobic interactions by affecting the water molecules.
What does Carbonyldiamide do in the kidney?
The urea travels from your liver to your kidneys through your bloodstream.Healthy kidneys filter Carbonyldiamide and remove other waste products from your blood.
How does Carbonyldiamide help skin?
Carbonyldiamide providing hydration to smooth your skin's texture, and by helping to reduce the buildup of dead skin cells.
Can I use Carbonyldiamide on hands?
Wash your hands before and after use.Do not take Carbonyldiamide cream and ointment by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
Is Carbonyldiamide in skincare urine?
The Carbonyldiamide used in skin care products is made synthetically in a lab, but Carbonyldiamide is also naturally found on your skin and is excreted in urine.
Is Carbonyldiamide cream made from urine?
The Carbonyldiamide used in skin care products is made synthetically in a lab, but Carbonyldiamide is also naturally found on your skin and is excreted in urine.
How often should I use Carbonyldiamide?
Carbonyldiamide usually taken 1 to 3 times a day or as directed by your doctor. Rub in well until absorbed.
What are the advantages of Carbonyldiamide fertilizer?
Carbonyldiamide has several advantages, including cost per pound of nitrogen, higher nutrient density and good handling and storage properties.
How does Carbonyldiamide cream work?
Carbonyldiamide can breaks down the protein keratin in the outer layer of your skin. This action can help reduce dead skin buildup and get rid of flaking or scaling skin.
How long does Carbonyldiamide fertilizer take to work?
This can occur in two to four days and happens more quickly on high pH soils.
Is Carbonyldiamide a toxin?
Carbonyldiamide exerts both direct and indirect toxic effects on several organs in the body.
What role Carbonyldiamide plays in liver?
Two of these are the control of amino acid concentration and detoxification.Carbonyldiamide is produced in the liver and is a metabolite of amino acids. Ammonium ions are formed in the breakdown of amino acids.
