Cebesine

Cebesine Uses, Dosage, Side Effects, Food Interaction and all others data.

Cebesine is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine. Cebesine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

Cebesine is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.

Trade Name Cebesine
Generic Oxybuprocaine
Oxybuprocaine Other Names Benoxinate, Oxibuprocaina, Oxybucaine, Oxybuprocaine, Oxybuprocainum, Oxyriprocaine
Type
Formula C17H28N2O3
Weight Average: 308.4158
Monoisotopic: 308.209992772
Groups Approved, Investigational
Therapeutic Class Ocular perioperative drugs
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Cebesine
Cebesine

Uses

Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.

Cebesine is also used to associated treatment for these conditions: Local Anesthesia of the Mouth

How Cebesine works

Cebesine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

Dosage

Cebesine dosage

Use as a 0.4% solution in short ophthalmic procedures. Instil 1 drop into the conjunctival sac to allow tonometry after 60 sec; a further drop after a 90 sec interval produces sufficiReduce systemic absorption by compressing the lacrimal sac at the medial canthus for a minute during and following instillation. Heart block; epilepsy, impaired cardiac conduction, myasthenia gravis; not to be applied to inflamed, infected tissues or damaged mucosa. Protect anaesthetised eye from dust and bacterial contamination; cornea may be damaged by prolonged application. Do not drive until normal vision restored.ent anaesthesia for the fitting of contact lenses; 3 drops at 90 sec intervals produces sufficient anaesthesia after 5 min for a foreign body to be removed from the corneal epithelium or for incision of a meibomian cyst through the conjunctiva.

Side Effects

Hypersensitivity reactions; transient stinging and blurring of vision; excitation of CNS; muscle twitching and tremors; convulsions.

Precaution

Reduce systemic absorption by compressing the lacrimal sac at the medial canthus for a minute during and following instillation. Heart block; epilepsy, impaired cardiac conduction, myasthenia gravis; not to be applied to inflamed, infected tissues or damaged mucosa. Protect anaesthetised eye from dust and bacterial contamination; cornea may be damaged by prolonged application. Do not drive until normal vision restored.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Innovators Monograph

You find simplified version here Cebesine

Cebesine contains Oxybuprocaine see full prescribing information from innovator Cebesine Monograph, Cebesine MSDS, Cebesine FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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