Cefaprin
Cefaprin Uses, Dosage, Side Effects, Food Interaction and all others data.
Cefaprin (INN, also spelled cephapirin), commonly marketed under the trade name Cefadyl, is a first-generation cephalosporin antibiotic that is available in injectable formulations. Production for use in humans has been discontinued in the United States. Cefaprin is partly plasma-bound and is effective against gram-negative and gram-positive organisms.
Cephapirin is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms. Cephapirin is more resistant to beta-lactamases than are the penicillins and so is effective against staphylococci, with the exception of methicillin-resistant staphylococci.
| Trade Name | Cefaprin |
| Generic | Cefapirin |
| Cefapirin Other Names | Cefapirin, Cefapirina, Cefapirine, Cefapirinum, Cefaprin, Cephapirin, Cephapirine |
| Type | |
| Formula | C17H17N3O6S2 |
| Weight | Average: 423.463 Monoisotopic: 423.055876671 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cefaprin is a first generation cephalosporin indicated in the treatment of susceptible bacterial infections.
For treatment of infections caused by susceptible bacteria.
Cefaprin is also used to associated treatment for these conditions: Bronchitis, Pharyngitis, Respiratory Tract Infections (RTI), Skin and Soft Tissue Infections, Tonsillitis, Urinary Tract Infection
How Cefaprin works
The bactericidal activity of cephapirin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Toxicity
Rats exposed via the oral route to cephapirin displayed low acute toxicity (LD50 = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects.
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