Cefotetan APP
Cefotetan APP Uses, Dosage, Side Effects, Food Interaction and all others data.
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Cefotetan APP is a semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
| Trade Name | Cefotetan APP |
| Availability | Prescription only |
| Generic | Cefotetan |
| Cefotetan Other Names | Cefotetan, Cefotetanum |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin |
| Type | |
| Formula | C17H17N7O8S4 |
| Weight | Average: 575.619 Monoisotopic: 575.002143315 |
| Protein binding | Cefotetan is 88% plasma protein bound. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | USA |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cefotetan APP is an antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections.
For prophylaxis and treatment of bacterial infections.
Cefotetan APP is also used to associated treatment for these conditions: Bacterial Infections, Bacterial Urinary Tract Infections, Bone and Joint Infections, Gonorrhea, Gynaecological infection, Intra-Abdominal Infections, Lower respiratory tract infection bacterial, Pelvic Inflammatory Disease (PID), Postoperative Infections, Septic, Antibiotic pre-surgical prophylaxis
How Cefotetan APP works
The bactericidal action of cefotetan results from inhibition of cell wall synthesis by binding and inhibiting the bacterial penicillin binding proteins which help in the cell wall biosynthesis.
Food Interaction
- Avoid alcohol. Alcohol can cause a disulfiram effect.
Cefotetan APP Alcohol interaction
[Moderate] GENERALLY AVOID:
Some cephalosporins may occasionally induce a disulfiram-like reaction when coadministered with alcohol.
The interaction has been reported for cefamandole, cefoperazone, cefotetan, and moxalactam.
These agents contain an N-methylthiotetrazole (NMTT) side chain that may inhibit aldehyde dehydrogenase (ALDH) similar to disulfiram.
Following ingestion of alcohol, inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the 'disulfiram reaction'.
Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion.
Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.
Cefonicid contains a structurally similar side chain but did not produce elevations in blood acetaldehyde or a disulfiram reaction to ethanol in 15 healthy volunteers given single and multiple one gram doses of the drug.
Patients receiving cephalosporins with the NMTT side chain should avoid the concomitant use of alcohol and alcohol-containing products.
Cefotetan APP Hypertension interaction
[Moderate] Parenteral cefotetan disodium contains approximately 80 mg (3.5 mEq) of sodium per each gram of cefotetan activity.
The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
Cefotetan APP Drug Interaction
Unknown: 5-hydroxytryptophan, 5-hydroxytryptophan, aspirin, aspirin, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, meperidine, meperidine, hetastarch, hetastarch, acetaminophen / oxycodone, acetaminophen / oxycodone, tiotropium, tiotropium, acetaminophen, acetaminophen, ampicillin / sulbactam, ampicillin / sulbactam, ondansetron, ondansetron
Cefotetan APP Disease Interaction
Major: colitis, hypoprothrombinemiaModerate: renal dysfunction, sodium, dialysis, disulfiram-like reaction, liver disease, seizure disorders
Volume of Distribution
- 10.4 L [elderly patients (greater than 65 years) with normal renal function]
- 10.3 L [healthy volunteers (aged 25 to 28 years)]
Half Life
In volunteers with reduced renal function, the plasma half-life of cefotetan is prolonged
Clearance
- 1.8 +/- 0.1 L/h [elderly patients with normal renal function (.65 years)]
- 1.8 +/- 0.3 L/h [healthy volunteers (aged 25 to 28 years)]
Elimination Route
No active metabolites of cefotetan have been detected; however, small amounts (less than 7%) of cefotetan in plasma and urine may be converted to its tautomer, which has antimicrobial activity similar to the parent drug. In normal patients, from 51% to 81% of an administered dose of Cefotetan APP is excreted unchanged by the kidneys over a 24 hour period, which results in high and prolonged urinary concentrations.
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