Cefpodoxime Proxetil

Cefpodoxime Proxetil Uses, Dosage, Side Effects, Food Interaction and all others data.

Cefpodoxime Proxetil
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Cefpodoxime Proxetil
Generic	Cefpodoxime Proxetil
Type
Therapeutic Class	Third generation Cephalosporins
Manufacturer
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Uses

Cefpodoxime is indicated for the treatment of infections caused by susceptible microorganism, listed below: Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenza, Moraxella catarrhalis (including beta-lactamase producing strains). Pharyngitis/tonsillitis caused by Streptococcus pyogenes. ... Read more

Dosage

Cefpodoxime Proxetil dosage

Adults and Adolescents (13 years and older)- Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days Acute maxillary sinusitis: 200 mg 12 hourly, 10 day Community-acquired pneumonia: 200 mg 12 hourly, 14 days Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days Skin and skin structure: 400 mg 12 hourly, 7 to 14 days Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days Uncomplicated gonorrhea: single dose of 200 mg Rectal gonococcal infections in women: single dose of 200 mg Infants and Pediatric Patients (2 months to 12 years)- Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days Patients with renal dysfunction: For patients with severe renal impairment (creatinine clearance <30ml/min) the dosing intervals should be increased to 24 hourly.Patients with liver cirrhosis: Cefpodoxime Proxetil pharmacokinetics in cirrhotic patients are similar to those in healthy subjects. Dose adjustment is not necessary in this population.

Side Effects

Cefpodoxime has very few side effects. The side effects include diarrhea, nausea, skin & vaginal fungal infection, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo, cough etc. In children incidence of fungal skin rash is more than adults.

Precaution

In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of Cefpodoxime Proxetil should be reduced. Cefpodoxime, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics. As with other broad spectrum antibiotics, prolonged use of Cefpodoxime Proxetil may result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient’s condition is essential.

Interaction

Antacids: Concomitant administration of high doses of antacids (sodium bicarbonate and aluminium hydroxide) or H 2 blockers reduce peak plasma level by 24% to 42% and the extent of absorption by 27% to 32%, respectively.Probenecid: Renal excretion of cefpodoxime was inhibited by probenecid and resulted in an approximately 31% increase in AUC.Nephrotoxic drugs: Close monitoring of renal function is advised when Cefpodoxime Proxetil is administered concomitantly with compounds of known nephrotoxic potential.

Pregnancy & Breastfeeding use

Cefpodoxime was neither teratogenic nor embryocidal in animal trial. There is, however, no adequate and well-controlled study of Cefpodoxime Proxetil use in pregnant woman. The drug should be used during pregnancy only if clearly needed. Because Cefpodoxime is excreted in human milk, a decision should be made wheather to discontinue breast-feeding or to discontinue the drug.