Ceftriaxone Mylan Generics
Ceftriaxone Mylan Generics Uses, Dosage, Side Effects, Food Interaction and all others data.
Ceftriaxone Mylan Generics is a sterile, semisynthetic, broad-spectrum, 3rd generation cephalosporin antibiotic for intravenous or intramuscular administration. The bactericidal activity of Ceftriaxone Mylan Generics results from inhibition of cell wall synthesis. Ceftriaxone Mylan Generics has a high degree of stability in the presence of beta-lactamases both penicillinases and cephalosporinases of gram-negative and gram- positive bacteria.
Ceftriaxone Mylan Generics is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ceftriaxone Mylan Generics has in vitro activity against gram-positive aerobic, gram-negative aerobic, and anaerobic bacteria. The bactericidal activity of ceftriaxone results from the inhibition of cell wall synthesis and is mediated through ceftriaxone binding to penicillin-binding proteins (PBPs). Ceftriaxone Mylan Generics is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended-spectrum beta-lactamases. However, resistance to ceftriaxone usually occurs through beta-lactamase hydrolysis, altered PBPs, or reduced bacterial cell permeability. Ceftriaxone Mylan Generics should not be mixed with or giving in the same IV line as diluents/products containing calcium as they may cause ceftriaxone to precipitate. Ceftriaxone Mylan Generics use may also cause biliary sludge or gallbladder pseudolithiasis.
| Trade Name | Ceftriaxone Mylan Generics |
| Availability | Prescription only |
| Generic | Ceftriaxone |
| Ceftriaxone Other Names | Ceftriaxona, Ceftriaxone, Ceftriaxonum, Rocephin |
| Related Drugs | amoxicillin, doxycycline, diclofenac ophthalmic, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, dexamethasone ophthalmic, levofloxacin |
| Type | |
| Formula | C18H18N8O7S3 |
| Weight | Average: 554.58 Monoisotopic: 554.04605704 |
| Protein binding | Ceftriaxone is 95% protein bound. |
| Groups | Approved |
| Therapeutic Class | Third generation Cephalosporins |
| Manufacturer | |
| Available Country | Italy |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ceftriaxone Mylan Generics is used for the treatment of the following infections when caused by susceptible organisms:
Lower Respiratory Tract Infections caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, E. coli, Enterobacter aerogenes, Proteus mirabilis, Serratia marcescens.
Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains), Moraxella catarrhalis (including beta-lactamase producing strains).
Skin and Skin Structure Infections caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, E. coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis, Peptostreptococcus species.
Urinary Tract Infections (complicated and uncomplicated) caused by E. coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Klebsiella pneumoniae.
Uncomplicated Gonorrhea (cervical, urethral, pharyngial and rectal) caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of Neisseria gonorrhoeae.
Pelvic Inflammatory Disease caused by Neisseria gonorrhoeae.
Bacterial Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae, Klebsiella pneumoniae.
Bone and Joint Infections caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species.
Intra-abdominal Infections caused by E. coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium species, Peptostreptococcus species.
Meningitis caused by Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae. Ceftriaxone Mylan Generics has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis and E. coli.
Surgical Prophylaxis: The preoperative administration of a single 1 gm dose of Ceftriaxone Mylan Generics may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated.
Ceftriaxone Mylan Generics is also used to associated treatment for these conditions: Arthritis gonococcal, Bacterial Endocarditis, Bacterial Infections, Bacterial Sepsis, Bacterial Sinusitis, Bone and Joint Infections, Brain abscess, Chancroid, Community Acquired Pneumonia (CAP), Conjunctivitis gonococcal neonatal, Epididymitis, Epiglottitis, Gonococcal infection of pharynx, Gonococcal pelvic inflammatory disease, Intra-Abdominal Infections, Lower respiratory tract infection bacterial, Lyme Neuroborreliosis, Meningitis, Bacterial, Ophthalmia neonatorum due to gonococcus, Postoperative Infections, Prosthetic Joint Infection, Salmonella Typhi Infection, Septic Arthritis, Shigellosis, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Vulvovaginitis gonococcal, Whipple Disease, Bacterial otitis media, Complicated Bacterial Urinary Tract Infections, Susceptible Bacterial Infections, Uncomplicated Gonorrhea, Uncomplicated Urinary tract infection bacterial
How Ceftriaxone Mylan Generics works
Ceftriaxone Mylan Generics works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. Binding of ceftriaxone to these enzymes causes the enzyme to lose activity; therefore, the bacteria produce defective cell walls, causing cell death.
Dosage
Ceftriaxone Mylan Generics dosage
Generally, Ceftriaxone Mylan Generics should be taken once or equally devided twice a day for 4-14 days. Ceftriaxone Mylan Generics therapy should be continued for at least 2 days after the sign and symptoms of infection have disappeared.
The usual duration of therapy is 4 to 14 days; in complicated infections longer therapy may be required. No dosage adjustment is required for patients with renal or hepatic impairment.
Use the solution immediately after reconstitution of powder.
Side Effects
Generally Ceftriaxone Mylan Generics is well tolerated. However, few side effects including nausea, vomiting, diarrhea, dizziness and fever may occur.
Toxicity
Ceftriaxone Mylan Generics overdose may increase the risk of urolithiasis and subsequent post-renal acute renal failure (PARF). Other symptoms of overdose unavailable in the literature. However, they are likely similar to the adverse effects of the medication. If overdose of ceftriaxone occurs, treat with symptomatic and supportive treatment, as ceftriaxone levels will not be reduced by dialysis.
Precaution
Ceftriaxone Mylan Generics should be administered with caution to individuals with a history of gastrointestinal disease, particularly colitis.
Interaction
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level with probenecid.
Food Interaction
No interactions found.Ceftriaxone Mylan Generics Drug Interaction
Moderate: furosemide, furosemideUnknown: aspirin, aspirin, amoxicillin / clavulanate, amoxicillin / clavulanate, albuterol / ipratropium, albuterol / ipratropium, lvp solution, lvp solution, insulin isophane, insulin isophane, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Ceftriaxone Mylan Generics Disease Interaction
Major: colitis, hyperbilirubinemiaModerate: gallbladder disease, pancreatitis, prothrombin time alterations, renal/liver disease, liver disease, seizure disorders
Volume of Distribution
The apparent volume of distribution of an intravenous or intramuscular dose in healthy patients is 5.78 to 13.5 L. The volume of distribution of an intravenous or intramuscular dose in septic patients is 6.48 to 35.2 L. Ceftriaxone Mylan Generics has good enough CSF penetration to be used as an effective treatment of bacterial meningitis.
Elimination Route
Ceftriaxone Mylan Generics is only given as an injection, either intramuscularly or intravenously. Ceftriaxone Mylan Generics is less than 1% bioavailable if given orally.
Half Life
The elimination half-life of ceftriaxone is 5.8-8.7 hours. The half-life of ceftriaxone in the middle ear fluid has been estimated to be 25 hours.
Clearance
The plasma clearance of ceftriaxone in healthy adults receiving a 0.15-3g dose is 0.58 to 1.45 L/hour. The renal clearance of ceftriaxone is 0.32 to 0.73 L/hour. In intensive care unit patients, ceftriaxone's total drug clearance was 0.96L/h (0.55-1.28 L/h), and unbound drug clearance was 1.91 L/h (1.46-6.20 L/h).
Elimination Route
Ceftriaxone Mylan Generics is primarily eliminated in the urine (33-67%). The remainder is eliminated through secretion in the bile and removed from the body via the feces.
Pregnancy & Breastfeeding use
Pregnancy: The safety of Ceftriaxone Mylan Generics in the treatment of infections during pregnancy has not been established. Ceftriaxone Mylan Generics should only be used during pregnancy if the likely benefit outweighs the potential risk to the fetus and/or the mother.
Lactation: Ceftriaxone Mylan Generics is excreted in breast milk at low concentrations. Therefore, caution should be exercised when Ceftriaxone Mylan Generics is administered to a nursing mother.
Contraindication
Ceftriaxone Mylan Generics should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. It is contraindicated in premature infants during the first 6 weeks of life. Its safety in human pregnancy has not been established. Ceftriaxone Mylan Generics is contraindicated in neonates if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium containing infusions such as parenteral nutrition because of the risk of precipitation of ceftriaxone-calcium.
Acute Overdose
There is no specific antidote. Treatment of over dosage should be symptomatic.
Storage Condition
Store below 25°C, protected from light & moisture. Use reconstituted solutions immediately.
Reconstituted solutions are stable for 6 hours at room temperature and for 24 hours at 2°-8°C. It should not be mixed in the same syringe with any drug other than 1% Lidocaine Hydrochloride injection BP (for IM injection only).
Innovators Monograph
You find simplified version here Ceftriaxone Mylan Generics
Ceftriaxone Mylan Generics contains Ceftriaxone see full prescribing information from innovator Ceftriaxone Mylan Generics Monograph, Ceftriaxone Mylan Generics MSDS, Ceftriaxone Mylan Generics FDA label
FAQ
What is Ceftriaxone Mylan Generics used for?
Ceftriaxone Mylan Generics is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.Ceftriaxone Mylan Generics is a cephalosporin antibiotic.
What are the common side effects of Ceftriaxone Mylan Generics?
Common side effects of Ceftriaxone Mylan Generics include:
- rash,
- diarrhea,
- nausea,
- vomiting,
- upset stomach,
- blood clots,
- dizziness,
- headache,
- pain or swelling in your tongue,
- a lump where the medicine was injected,
- sweating,
- vaginal itching or discharge,
- vaginal yeast infection,
- anemia,
- changes in taste, or
- flushing.
How safe is Ceftriaxone Mylan Generics?
FDA alert states that generally, fatalities have been associated with simultaneous administration of Ceftriaxone Mylan Generics and calcium-containing products.administration of the two products at different times and via different infusion lines has also been fatal.
Who should not take Ceftriaxone Mylan Generics?
A type of blood disorder where the red blood cells burst called hemolytic anemia. Liver problems. disease of the gallbladder. Severe renal impairment.
Is Ceftriaxone Mylan Generics safe during pregnancy?
What are the benefits of Ceftriaxone Mylan Generics?
Ceftriaxone Mylan Generics is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia, or meningitis.Ceftriaxone Mylan Generics is also used to prevent infection in people having certain types of surgery.
Is Ceftriaxone Mylan Generics safe during breastfeeding?
Ceftriaxone Mylan Generics is acceptable in nursing mothers.
Can I take Ceftriaxone Mylan Generics without food?
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Ceftriaxone Mylan Generics, there are no specific foods that you must exclude from your diet when receiving this medication.
Which foods should be avoided during treatment with Ceftriaxone Mylan Generics?
Foods that must be avoided while on antibiotic treatment include grapefruit, foods rich in calcium.
Can I drink alcohol after taking Ceftriaxone Mylan Generics?
It is best not to drink alcohol for up to 48 hours after the injection.
How many days should Ceftriaxone Mylan Generics injection be taken?
It is sometimes given as a single dose and sometimes given once or twice a day for 4-14 days, depending on the type of infection being treated.
How long can I take Ceftriaxone Mylan Generics?
Ceftriaxone Mylan Generics is sometimes given for up to 14 days. Read and carefully follow any Instructions for Use provided with your medicine.
Can I drive after taking Ceftriaxone Mylan Generics ?
Ceftriaxone Mylan Generics can cause dizziness. If you feel dizzy, do not drive or use any tools or machines.
How does Ceftriaxone Mylan Generics work in the body?
Ceftriaxone Mylan Generics works by interfering with the formation of bacterial cell walls. Ceftriaxone Mylan Generics impairs the bonds that hold the bacterial cell wall together, which allows holes to appear in the cell walls.
Where is Ceftriaxone Mylan Generics injected?
Ceftriaxone Mylan Generics is injected into a muscle or as an infusion into a vein (IV).
Can I take Ceftriaxone Mylan Generics without food?
In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Ceftriaxone Mylan Generics, there are no specific foods that you must exclude from your diet when receiving this medication.
