Ceham M

Ceham M Uses, Dosage, Side Effects, Food Interaction and all others data.

Citicoline is a naturally occurring, water-soluble biological compound that is essential intermediate for the synthesis of phosphatidylcholine, a major constituent of the gray matter of brain tissue. Citicoline promotes brain metabolism by enhancing the synthesis of acetylcholine and restoring phospholipid content in the brain. It also elevates brain oxygen consumption and improves brain metabolism. Citicoline seems to increase a brain chemical called phosphatidylcholine. This brain chemical is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured.

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Trade Name Ceham M
Generic Mecobalamin + Citicoline
Weight 750mg
Type Tablet
Therapeutic Class
Manufacturer Alkem Laboratories Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Ceham M
Ceham M

Uses

Use for the improvement of thinking, learning and memory in people suffering from Alzheimer's disease, dementia, head trauma, Parkinson's disease and glaucoma. Also used in loss of consciousness due to brain damage, head injury or brain surgery and cerebral infarction, age-related memory problems and stroke.

Mecobalamin is used for-

  • Peripheral Neuropathies
  • Diabetic Neuropathy
  • Verteberal Syndrome
  • Nerve Compression Syndrome
  • Multiple sclerosis
  • Amyotrophic lateral sclerosis
  • Parkinson’s disease
  • Alzheimer’s disease
  • Diabetic retinopathy
  • Entrapment neuropathy
  • Drug induced neuropathy
  • Megaloblastic anemia due to Vitamin B12 deficiency

Ceham M is also used to associated treatment for these conditions: Degenerative Brain Disorder, Parkinsonian SyndromesVitamin B12 Deficiency, Nutritional supplementation

Dosage

Ceham M dosage

Disturbance of Consciousness: Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily.

Psychologic or Neurologic Disorders: Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once daily for 2 consecutive weeks or as prescribed by the physician.

Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.

Injection:

  • Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
  • Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy

Side Effects

Rash, Insomnia, headache, dizziness, convulsion, Nausea, anorexia, Abnormal liver function in laboratorium measurement, Diplopia, Flushing, transient blood pressure changes or malaise.

Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.

Precaution

In acute and emergency condition, citicoline should be administered. In conjunction with intracranial pressure-relieving drugs or homostatic and treatment eg, hypothermy. If intracranial bleeding continue, avoid giving high-dose citicoline (>500 mg concomitantly), since it may exaggerate blood flow in brain. In case small dose of citicoline (100-500 mg 2-3 times daily) may be needed.

Precaution should be given in patients with hypersensitivity. For patients with disturbance of consciousness in acute stage of cerebral infarction, start of citicoline injection recommended within 2 weeks after apoplectic stroke.

Use in pregnancy: Citicoline is avoided in pregnancy.

Use in lactation: Citicoline is avoided by nursing mothers.

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Interaction

Zynapse potentiates the effects of L-dopa.

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Pregnancy & Breastfeeding use

There is inadequate evidence of safe use of citicoline in human pregnancy. Citicoline should be used in pregnancy and lactation only if the potential benefits justify the potential risks.

Not recommended during pregnancy & lactation.

Contraindication

Hypersensitivity to citicoline sodium or to any of the excipients of Citicoline.

Hypersensitivity to any component of this product.

Special Warning

Use in children: Not recommended.

Storage Condition

Store below 25° C

Oral: Store at room temperature. Protect from moisture and light.

Parenteral: Store at room temperature. Do not expose to direct light.

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*** Taking medicines without doctor's advice can cause long-term problems.
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