Cercul

Cercul Uses, Dosage, Side Effects, Food Interaction and all others data.

Citicoline is a naturally occurring, water-soluble biological compound that is essential intermediate for the synthesis of phosphatidylcholine, a major constituent of the gray matter of brain tissue. Citicoline promotes brain metabolism by enhancing the synthesis of acetylcholine and restoring phospholipid content in the brain. It also elevates brain oxygen consumption and improves brain metabolism. Citicoline seems to increase a brain chemical called phosphatidylcholine. This brain chemical is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured.

Cercul
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Cercul
Generic	Citicoline + Citicoline
Weight	130, 368mg, 125mg/ml
Type	Injection
Therapeutic Class
Manufacturer	PT Phapros
Available Country	Indonesia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Use for the improvement of thinking, learning and memory in people suffering from Alzheimer's disease, dementia, head trauma, Parkinson's disease and glaucoma. Also used in loss of consciousness due to brain damage, head injury or brain surgery and cerebral infarction, age-related memory problems and stroke.

Cercul is also used to associated treatment for these conditions: Degenerative Brain Disorder, Parkinsonian Syndromes

Dosage

Cercul dosage

Disturbance of Consciousness: Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily.

Psychologic or Neurologic Disorders: Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once daily for 2 consecutive weeks or as prescribed by the physician.

Side Effects

Rash, Insomnia, headache, dizziness, convulsion, Nausea, anorexia, Abnormal liver function in laboratorium measurement, Diplopia, Flushing, transient blood pressure changes or malaise.

Precaution

In acute and emergency condition, citicoline should be administered. In conjunction with intracranial pressure-relieving drugs or homostatic and treatment eg, hypothermy. If intracranial bleeding continue, avoid giving high-dose citicoline (>500 mg concomitantly), since it may exaggerate blood flow in brain. In case small dose of citicoline (100-500 mg 2-3 times daily) may be needed.

Precaution should be given in patients with hypersensitivity. For patients with disturbance of consciousness in acute stage of cerebral infarction, start of citicoline injection recommended within 2 weeks after apoplectic stroke.

Use in pregnancy: Citicoline is avoided in pregnancy.

Use in lactation: Citicoline is avoided by nursing mothers.

Interaction

Zynapse potentiates the effects of L-dopa.

Pregnancy & Breastfeeding use

There is inadequate evidence of safe use of citicoline in human pregnancy. Citicoline should be used in pregnancy and lactation only if the potential benefits justify the potential risks.