Cetohyroxamic Acid

Cetohyroxamic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.

Trade Name Cetohyroxamic Acid
Generic Acetohydroxamic acid
Acetohydroxamic acid Other Names Acethydroxamsaeure, Acetic acid, oxime, Acetohydroxamate, Acetohydroxamic acid, Acetohydroximic acid, Acetyl hydroxyamino, Acetylhydroxamic acid, Acide acetohydroxamique, Acido acetohidroxamico, Acidum acetohydroxamicum, Cetohyroxamic acid, Methylhydroxamic acid, N-Acetyl hydroxyacetamide, N-Acetylhydroxylamine, N-Hydroxyacetamide
Type
Formula C2H5NO2
Weight Average: 75.0666
Monoisotopic: 75.032028409
Protein binding

No known binding

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Cetohyroxamic Acid
Cetohyroxamic Acid

Uses

Cetohyroxamic Acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract.

Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.

Cetohyroxamic Acid is also used to associated treatment for these conditions: Chronic urea-splitting urinary infection

How Cetohyroxamic Acid works

Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate.

Toxicity

Oral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.

Food Interaction

  • Avoid alcohol. Concomitant use of acetohydroxamic acid with alcohol may cause a rash.
  • Avoid iron supplements. Cetohyroxamic Acid chelates iron, therefore oral supplementation of iron will reduce levels of both iron and acetohydroxamic acid.
  • Take on an empty stomach.

Elimination Route

Well absorbed from the GI tract following oral administration.

Half Life

5-10 hours in patients with normal renal function

Innovators Monograph

You find simplified version here Cetohyroxamic Acid

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0000265
http://classyfire.wishartlab.com/tax_nodes/C0001093
http://classyfire.wishartlab.com/tax_nodes/C0003223
http://classyfire.wishartlab.com/tax_nodes/C0003922
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:49029
http://www.hmdb.ca/metabolites/HMDB0014691
http://www.genome.jp/dbget-bin/www_bget?drug:D00220
http://www.genome.jp/dbget-bin/www_bget?cpd:C06808
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1990
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508546
https://www.chemspider.com/Chemical-Structure.1913.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099857
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=16728
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=49029
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL734
https://zinc.docking.org/substances/ZINC000004658603
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001277
http://www.pharmgkb.org/drug/PA164749213
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/HAE
https://www.drugs.com/cdi/acetohydroxamic-acid.html
https://en.wikipedia.org/wiki/Acetohydroxamic_acid
*** Taking medicines without doctor's advice can cause long-term problems.
Share