Chantix Starter Pack
Chantix Starter Pack Uses, Dosage, Side Effects, Food Interaction and all others data.
Chantix Starter Pack binds with high affinity and selectivity at α4β2 neuronal nicotinic acetylcholinereceptors. The efficacy of Chantix Starter Pack in smoking cessation is believed to be the result of varenicline's activity at α4β2 sub-type of the nicotinic receptor where its binding produces agonist activity, while simultaneously preventing nicotine binding to these receptors.Electrophysiology studies in vitro and neurochemical studies in vivo have shown that varenicline binds to α4β2 neuronal nicotinic acetylcholine receptors and stimulates receptor-mediated activity, but at a significantly lower level than nicotine. Chantix Starter Pack blocks the ability of nicotine to activate α4β2 receptors and thus to stimulate the central nervous mesolimbic dopamine system, believed to be the neuronal mechanism underlying reinforcement and reward experienced upon smoking. Chantix Starter Pack is highly selective and binds more potently to α4β2 receptors than to other common nicotinic receptors ( >500-fold α3β4, >3,500fold α7, >20,000-fold α1βγδ), or to non-nicotinic receptors and transporters (> 2,000-fold). Chantix Starter Pack also binds with moderate affinity (Ki = 350 nM) to the 5-HT3 receptor.
Chantix Starter Pack is a partial nicotinic acetylcholine receptor agonist, designed to partially activate this system while displacing nicotine at its sites of action in the brain.
Trade Name | Chantix Starter Pack |
Availability | Prescription only |
Generic | Varenicline |
Varenicline Other Names | Vareniclina, Varenicline, Vareniclinum |
Related Drugs | Xiidra, bupropion, cyclosporine ophthalmic, Chantix, Restasis, nicotine, Systane, Artificial Tears, Zyban, Nicoderm CQ |
Weight | 0.5mg, 0.5mg + 1mg, 1mg |
Type | Oral, Oral Tablet |
Formula | C13H13N3 |
Weight | Average: 211.268 Monoisotopic: 211.110947431 |
Protein binding | Less than 20%. |
Groups | Approved, Investigational |
Therapeutic Class | Drugs used in substance dependence |
Manufacturer | |
Available Country | United States |
Last Updated: | September 19, 2023 at 7:00 am |
How Chantix Starter Pack works
Chantix Starter Pack is an alpha-4 beta-2 neuronal nicotinic acetylcholine receptor partial agonist. The drug shows high selectivity for this receptor subclass, relative to other nicotinic receptors (>500-fold alpha-3 beta-4, >3500-fold alpha-7, >20,000-fold alpha-1 beta gamma delta) or non-nicotinic receptors and transporters (>2000-fold). The drug competitively inhibits the ability of nicotine to bind to and activate the alpha-4 beta-2 receptor. The drug exerts mild agonistic activity at this site, though at a level much lower than nicotine; it is presumed that this activation eases withdrawal symptoms.
Dosage
Chantix Starter Pack dosage
Smoking cessation therapies are more likely to succeed for patients who are motivated to stop smoking and who are provided additional advice and support. Provide patients with appropriate educational materials and counseling to support the quit attempt.The patient should set a date to stop smoking. Begin Chantix Starter Pack dosing one week before this date. Alternatively, the patient can begin Chantix Starter Pack dosing and then quit smoking between days 8 and 35 of treatment.The recommended dose of Chantix Starter Pack is 1 mg twice daily following a 1-week titration as follows:
- Days 1-3: 0.5 mg once daily
- Days 4-7: 0.5 mg twice daily
- Day 8-end of treatment: 1 mg twice daily
Patients should be treated with Chantix Starter Pack for 12 weeks. For patients who have successfully stopped smoking at the end of 12 weeks, an additional course of 12 weeks treatment with Chantix Starter Pack is recommended to further increase the likelihood of long-termabstinence.For patients who are sure that they are not able or willing to quit abruptly, consider a gradual approach to quitting smoking with Chantix Starter Pack. Patients should begin Chantix Starter Pack dosing and reduce smoking by 50% from baseline within the first four weeks, by an additional 50% in the next four weeks, and continue reducing with the goal of reaching complete abstinence by 12 weeks. Continue Chantix Starter Pack treatment for an additional 12 weeks, for a total of 24 weeks of treatment. Encourage patients to attempt quitting sooner if they feel readyPatients who are motivated to quit, and who did not succeed in stopping smoking during prior Chantix Starter Pack therapy for reasons other than intolerability due to adverse events or who relapsed after treatment, should be encouraged to make another attempt with Chantix Starter Pack once factors contributing to the failed attempt have been identified and addressed.Consider a temporary or permanent dose reduction in patients who cannot tolerate the adverse effects of Chantix Starter Pack.
Chantix Starter Pack should be taken orally after eating and with a full glass of water.
Side Effects
Nasopharyngitis, bronchitis, sinusitis, increased wt, decreased &/or increased appetite, abnormal dreams, insomnia, headache, somnolence, dizziness, dysgeusia, dyspnea, cough, nausea, GERD, vomiting, constipation, diarrhea, abdominal distension & pain, toothache, dyspepsia, flatulence, dry mouth, rash, pruritus, arthralgia, myalgia, back pain, chest pain, fatigue, abnormal liver function test.
Precaution
Discontinue use if changes in behavior or thinking, agitation or depressed mood, anxiety, psychosis, mood swings, aggressive behavior, agitation, depressed mood, suicidal ideation & behavior. Concomitant use in patients attempting to quit smoking. Patients with history of seizures or other conditions that potentially lower seizure threshold. Report if patients had history of psychiatric illness prior to initiation. Hypersensitivity reactions including angioedema, swelling of the face, mouth (tongue, lips, gums), neck (throat & larynx) & extremities. Severe cutaneous reactions including Stevens-Johnson syndrome & erythema multiforme (rare). Special Precautions for Disposal and Other Handling: No special requirements for disposal.
Interaction
May increase intoxicating effects of alcohol.
Food Interaction
- Avoid excessive or chronic alcohol consumption. Chantix Starter Pack may increase the effects of alcohol; therefore, reduce consumption of alcohol when starting varenicline.
[Moderate] GENERALLY AVOID: Chantix Starter Pack may enhance the effects of alcohol as well as alter the way an individual reacts to alcohol.
During postmarketing use, some patients have reported experiencing increased intoxicating effects of alcohol while taking varenicline.
In addition, some reported cases of neuropsychiatric events, including unusual and sometimes aggressive behavior directed toward oneself or others, may have been worsened by concomitant use of alcohol.
These events were often accompanied by amnesia.
Patients should immediately stop taking varenicline and contact their physician if they develop agitation, hostility, aggressive behavior, depressed mood, or changes in behavior or thinking that are not typical for them, or if they develop suicidal ideation or behavior.
MANAGEMENT: Patients should be advised to limit their consumption of alcohol until they know whether varenicline affects their tolerance for alcohol, and to exercise caution driving or operating machinery until they know how quitting smoking and
Chantix Starter Pack Disease Interaction
Major: neuropsychiatric eventsModerate: alcoholism, CV disease, renal impairment, seizures
Half Life
The elimination half-life of varenicline is approximately 24 hours
Elimination Route
Chantix Starter Pack undergoes minimal metabolism, with 92% excreted unchanged in the urine. Renal elimination of varenicline is primarily through glomerular filtration along with active tubular secretion possibly via the organic cation transporter, OCT2.
Pregnancy & Breastfeeding use
Use in Pregnancy: Category C. There are no adequate and well-controlled studies in pregnant women. Chantix Starter Pack should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus
Use in Lactation: It is unknown whether varenicline is excreted in human breast milk. Animal studies suggest that varenicline is excreted in breast milk. A decision on whether to discontinue breast-feeding or to discontinue therapy with varenicline should be made taking into account the benefit of breast-feeding to the child and the benefit of varenicline therapy to the woman
Contraindication
Known hypersensitivity to varenicline or to any of the excipients in the product (microcrystalline cellulose, dibasic calcium phosphate, anhydrous, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, Opadry Blue/White and Opadry Clear).
Innovators Monograph
You find simplified version here Chantix Starter Pack
Chantix Starter Pack contains Varenicline see full prescribing information from innovator Chantix Starter Pack Monograph, Chantix Starter Pack MSDS, Chantix Starter Pack FDA label
FAQ
What is Chantix Starter Pack used for?
Chantix Starter Pack is used along with education and counseling to help people stop smoking. It works by blocking the pleasant effects of nicotine (from smoking) on the brain.
What are the common side effects of Chantix Starter Pack?
Chantix Starter Pack may cause side effects include:
- nausea
- constipation
- diarrhea
- gas
- abdominal pain
- vomiting
- heartburn
- bad taste in the mouth
- dry mouth
- increased or decreased appetite
- toothache
- trouble falling asleep or staying asleep
- unusual dreams or nightmares
- headache
- lack of energy
- back, joint, or muscle pain
- abnormal menstrual cycles
How long can you take Chantix Starter Pack?
Most people take Chantix Starter Pack for 12 weeks.
Is Chantix Starter Pack safe during pregnany?
Given the uncertainty about the safety of Chantix Starter Pack and bupropion during pregnancy, these therapies are not recommended in pregnant women.
Is Chantix Starter Pack safe during breastfeeding?
Chantix Starter Pack might interfere with normal infant lung development and recommends against its use in nursing mothers.Because no information is available on the use of brans during breastfeeding, an alternate drug is preferred, especially while nursing a newborn or preterm infant.
Can you drink alcohol while taking Chantix Starter Pack?
Chantix Starter Pack can alter people's reaction when drinking alcohol, potentially causing a lowered tolerance, blackouts, and aggressive behavior.
Can I smoke on Chantix Starter Pack?
It is okay to smoke during this time. Stop smoking on the quit date. Take the dose prescribed by your doctor twice a day for the rest of the treatment period (usually 12 weeks). Another way to use Chantix Starter Pack is to start taking the drug before you choose a date to quit smoking.
Can I take Chantix Starter Pack forever?
You should take Chantix Starter Pack for the full 12 or 24 weeks (3 or 6 months), depending on the quit approach you and your healthcare provider decide is right for you.
Does Chantix Starter Pack make I tired?
Chantix Starter Pack may make you feel sleepy, dizzy, or have trouble concentrating, making it hard to drive or perform other activities safely.
Does Chantix Starter Pack cause weight gain?
Chantix Starter Pack can cause notoriously weird, vivid dreams, and is believed by many to have darker psychiatric effects.
What are the long term effects of taking Chantix Starter Pack?
depression, mania, psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide in patients attempting to quit smoking while taking Chantix Starter Pack.
Can Chantix Starter Pack raise your blood pressure?
Nicotine patches and the stop-smoking pills can potentially increase blood pressure.
Is Chantix Starter Pack addictive?
May produce mild physical dependence which is not associated with addiction.
How many people died from taking Chantix Starter Pack?
Anti-smoking drug Chantix Starter Pack linked to more than 500 suicides.
Is Chantix Starter Pack bad for my heart?
Chantix Starter Pack has been linked to an increased risk for heart attacks, strokes, and other cardiovascular events.
What is the best time of day to take Chantix Starter Pack?
Chantix Starter Pack should always be taken after eating, with a full glass of water. During the first week of taking Chantix Starter Pack your dose will gradually increase.
How long should Chantix Starter Pack be taken?
You should take Chantix Starter Pack for the full 12 or 24 weeks (3 or 6 months), depending on the quit approach you and your healthcare provider decide is right for you.
What is the success rate of Chantix Starter Pack?
Chantix Starter Pack users were 60% more successful at quitting smoking at 1 year.
Can I drive after taking Chantix Starter Pack?
Do not drive, cycle or operate machinery until you feel safe again. If you feel dizzy, sit or lie down until you feel better.
How long does it take for Chantix Starter Pack to build up in your system?
During the first week of taking Chantix Starter Pack, you will slowly increase the dose over 7 days to give it time to build up in your body.