Cheladrate

Cheladrate Uses, Dosage, Side Effects, Food Interaction and all others data.

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Edetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning.

Trade Name Cheladrate
Generic Edetic acid
Edetic acid Other Names Acide edetique, Acide ethylenediaminetetracetique, Acido edetico, Acidum edeticum, Edetic acid, EDTA, Ethylenediaminetetraacetate, Ethylenediaminetetraacetic acid
Type
Formula C10H16N2O8
Weight Average: 292.2426
Monoisotopic: 292.090665498
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Cheladrate
Cheladrate

Uses

Cheladrate is a chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias.

For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.

Cheladrate is also used to associated treatment for these conditions: Poisoning, Lead, Toxic encephalopathy

How Cheladrate works

The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased.

Toxicity

Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.

Food Interaction

  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Elimination Route

Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.

Half Life

The half life of edetate calcium disodium is 20 to 60 minutes.

Elimination Route

It is excreted primarily by the kidney, with about 50% excreted in one hour and over 95% within 24 hours.2 Almost none of the compound is metabolized.

Innovators Monograph

You find simplified version here Cheladrate

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0000265
http://classyfire.wishartlab.com/tax_nodes/C0002966
http://classyfire.wishartlab.com/tax_nodes/C0002966
http://classyfire.wishartlab.com/tax_nodes/C0002404
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004176
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:42191
http://www.hmdb.ca/metabolites/HMDB0015109
http://www.genome.jp/dbget-bin/www_bget?drug:D00052
http://www.genome.jp/dbget-bin/www_bget?cpd:C00284
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6049
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508301
https://www.chemspider.com/Chemical-Structure.5826.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330325
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1370600
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=42191
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL858
https://zinc.docking.org/substances/ZINC000019364242
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC000594
http://www.pharmgkb.org/drug/PA449439
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/EDT
http://www.rxlist.com/cgi/generic2/canaversenate.htm
https://en.wikipedia.org/wiki/Ethylenediaminetetraacetic_acid
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