Chenodesoxycholic Acid
Chenodesoxycholic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
Chenodesoxycholic Acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodesoxycholic Acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decrease the formation of gallstones. It can also reduce the amount of other bile acids that can be harmful to liver cells when levels are elevated.
It acts by reducing levels of cholesterol in the bile, helping gallstones that are made predominantly of cholesterol to dissolve. Chenodesoxycholic Acid is ineffective with stones of a high calcium or bile acid content.
| Trade Name | Chenodesoxycholic Acid |
| Generic | Chenodeoxycholic acid |
| Chenodeoxycholic acid Other Names | Acide chenodeoxycholique, Acido chenodeoxicholico, Acidum chenodeoxycholicum, Anthropodeoxycholic acid, Anthropodesoxycholic acid, CDCA, Chenic acid, Chenocholic acid, Chenodeoxycholate, Chenodeoxycholic acid, Chenodesoxycholic acid, Chenodiol, Gallodesoxycholic acid |
| Type | |
| Formula | C24H40O4 |
| Weight | Average: 392.572 Monoisotopic: 392.292659768 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Chenodesoxycholic Acid is a bile acid used for the treatment of primary biliary cirrhosis.
Chenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.
Chenodesoxycholic Acid is also used to associated treatment for these conditions: Radiolucent Cholesterol gallstones
How Chenodesoxycholic Acid works
Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Bile acids may also bind the the bile acid receptor (FXR) which regulates the synthesis and transport of bile acids.
Toxicity
Hepatotoxic.
Food Interaction
No interactions found.Elimination Route
Chenodiol is well absorbed from the small intestine.
Elimination Route
About 80% of its bacterial metabolite lithocholate is excreted in the feces.
Innovators Monograph
You find simplified version here Chenodesoxycholic Acid
