Choline C11

Choline C11 Uses, Dosage, Side Effects, Food Interaction and all others data.

Choline C 11 Injection is a radioactive diagnostic agent for positron emission tomography (PET) imaging of pat ients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging.

In a study of men with prostatic hyperplasia or primary prostate cancer, PET imaging showed 11C-choline radioactivity accumulated rapidly within the prostate; uptake appeared to peak by five minutes following injection of the drug and activity was retained over the subsequent 30 minute scanning period. Little uptake was observed in the bladder and rectum.

Choline C11
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Choline C11
Generic	Choline C-11
Choline C-11 Other Names	(11)C-choline, Choline C11
Type
Formula	C₅H₁₄NO
Weight	Average: 103.173 Monoisotopic: 103.118424313
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Choline C11 is an imaging agent used in positron emission tomography imaging for suspected recurrent prostate cancer and non-informative bone scintigraphy, computerized tomography, or magnetic resonance imaging.

Choline C 11 Injection is indicated for positron emission tomography (PET) imaging of patients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging (MRI). In these patients, 11 C-choline PET imaging may help identify potential sites of prostate cancer recurrence for subsequent histologic confirmation. Suspected prostate recurrence is based upon elevated blood prostate specific antigen (PSA) levels following initial therapy. In clinical studies, imag es w ere produced with PET/CT coregistration.

Choline C11 is also used to associated treatment for these conditions: Prostate Cancer

How Choline C11 works

Choline C 11 Injection is a radiolabeled analog of choline, a precursor molecule essential for the biosynthesis of cell membrane phospholipids. Choline is involved in synthesis of the structural components of cell membranes, as well as modulation of trans-membrane signaling. Increased phospholipid synthesis (i.e., increased uptake of choline) has been associated with cell proliferation and the transformation process that occurs in tumor cells.

Food Interaction

Drink plenty of fluids. Consuming lots of fluid before the PET/CT will reduce excess exposure to radiation by increasing urinary voiding.
Take on an empty stomach. Avoid eating for at leats 6 hours before the administration of Choline C11.