Chymex Ds
Chymex Ds Uses, Dosage, Side Effects, Food Interaction and all others data.
Chymex Ds (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chymotrypsin is activated from its inactive zymogen precursor, chymotrypsinogen, in presence of Trypsin. Chymex Ds is the most abundant pancreatic proteases that represent up to 10-20% of the total protein synthesized by the exocrine pancreas . Chymex Ds contains both the catalytic triad and oxyanion hole, and the tertiary structure of chymotrypsin is similar to Trypsin .
Chymex Ds is a digestive enzyme synthesized in the pancreas that plays an essential role in proteolysis, or the breakdown of proteins and polypeptides. As a component in the pancreatic juice, chymotrypsin aids in the digestion of proteins in the duodenum by preferentially cleaving peptide amide bonds.
| Trade Name | Chymex Ds |
| Generic | Chymotrypsin |
| Chymotrypsin Other Names | alpha-Chymotrypsin, Chymotrypsin, Chymotrypsin A, Chymotrypsin B, Chymotrypsine, Chymotrypsinum, Quimotripsina |
| Type | Tablet |
| Protein binding | No pharmacokinetic data available. |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | Excare Laboratories |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Chymex Ds is a digestive enzyme supplement used as supportive therapy to manage the side effects associated with conventional chemotherapy, radiotherapy, and hormone therapy.
No therapeutic indications.
Chymex Ds is also used to associated treatment for these conditions: Colorectal Cancers, Head & Neck Squamous Cell Carcinoma, Locally Advanced Cervical Cancer, Locally Advanced Non-Small Cell Lung Cancer, Multiple Myeloma (MM), Primary Non-metastatic Breast Cancer
How Chymex Ds works
Chymex Ds is synthesized by pancreatic acinar cells as an inactive precursor, chymotrypsinogen, that is secreted to the duodenum and activated via trypsin-induced cleavage. It also induces its own activation by cleaving essential amino acid residues in the oxyanion hole to produce α-Chymex Ds, which is a more stable form than π-Chymex Ds. Residues His-57, Asp-102, and Ser-195 form the catalytic triad while residues 189–195, 214–220, and 225–228 form the primary substrate-binding pocket called S1 binding pocket . Residue 189 in the polar serine residue that lies at the bottom of the S1 binding pocket . Chymex Ds favors aromatic residues like phenylalanine, tyrosine, and tryptophan but may hydrolyze other bonds in peptides at slower rates.
Toxicity
No toxicokinetic data available.
Food Interaction
- Take with food.
Volume of Distribution
No pharmacokinetic data available.
Elimination Route
No pharmacokinetic data available.
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
No pharmacokinetic data available.
Innovators Monograph
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FAQ
What is Chymex Ds used for?
People use Chymex Ds to make medicine. People take Chymex Ds by mouth or as a shot to reduce redness and swelling associated with pockets of infection (abscesses), ulcers, surgery, or traumatic injuries; and to help loosen phlegm in asthma, bronchitis, lung diseases, and sinus infections.
How safe is Chymex Ds?
Chymex Ds is safe when used in the eye by a healthcare professional. Chymex Ds can cause side effects when used in the eye, including an increase in pressure in the eye and other eye conditions such as uveitis, paralysis of the iris, and keratitis.
How does Chymex Ds work?
Chymex Ds cleaves peptide bonds by attacking the unreactive carbonyl group with a powerful nucleophile, the serine 195 residue located in the active site of the enzyme, which briefly becomes covalently bonded to the substrate, forming an enzyme-substrate intermediate.
What are the common side effects of Chymex Ds?
Common side effects of Chymex Ds include are itching, shortness of breath, swelling of the lips or throat, shock, loss of consciousness, and death.
Is Chymex Ds safe during pregnancy?
Not enough is known about the use of Chymex Ds during pregnancy. Stay on the safe side and avoid use.
Is Chymex Ds safe during breastfeeding?
You should not breastfeed while taking this medicine. You should consult your doctor before using this medicine during breastfeeding.
Can I drink alcohol with Chymex Ds?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Who should not take Chymex Ds?
Avoid Chymex Ds if you have any allergies to it. Seek immediate medical attention if you notice any symptoms such as a skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
What happen If I missed Chymex Ds?
If you forget to take a dose of Chymex Ds, take it as soon as you remember. If you miss a scheduled dose, skip the missed dose. Do not double the dose to make up for the missed one.
Can I overdose on Chymex Ds?
You should not take more than the prescribed dose. Seek emergency medical attention or contact your doctor in case of an overdose with Chymex Ds.
When should be taken of Chymex Ds?
Chymex Ds is most effective when you take it 30 minutes before a meal. Swallow the tablet whole with a sufficient amount of water.
How long does Chymex Ds take to work?
Some people may notice an improvement within three to seven days when taking Chymex Ds.
Can I take Chymex Ds for a long time?
Chymex Ds is possibly safe for most people when mixed with trypsin and used short-term.
How much Chymex Ds can I take daily?
Doses up to 800,000 units per day of this combination have been used safely for up to 10 days.
Is Chymex Ds an inhibitor?
Many food plants contain one or more protease inhibitors (e.g. chymotrypsin or trypsin inhibitors) that competitively inhibit the activity of proteolytic enzymes.
