Cinkef-U

Cinkef-U Uses, Dosage, Side Effects, Food Interaction and all others data.

5-Cinkef-U works by inhibiting the enzyme thymidylate kinase which results in reduced formation of thymidine and thus DNA. The active metabolite FdUMP appears to form a stable complex with the folate cofactor N-5, 10-methylene tetrahydrofolate which inactivates thymidylate kinase. 5-Fluril as FdUMP is also incorporated into RNA which results in fluorination of RNA. The effect of fluorouracil on living cells is limited mainly to those in the proliferative phase but while cells in the G2 and S phase are most affected there may be effects at any stage of the cell cycle.

Cinkef-U is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances from becoming incorporated into DNA during the "S" phase (of the cell cycle), stopping normal development and division. Cinkef-U blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Cinkef-U blocks the incorporation of the thymidine nucleotide into the DNA strand.

Trade Name Cinkef-U
Availability Prescription only
Generic Fluorouracil
Fluorouracil Other Names 5-Fluoracil, 5-Fluorouracil, 5-Fluracil, 5-FU, Fluoro Uracil, Fluorouracil, Fluorouracilo, Fluorouracilum, Fluouracil
Related Drugs estradiol, tamoxifen, Premarin, testosterone, Keytruda, Arimidex, megestrol, carboplatin, capecitabine, pembrolizumab
Type
Formula C4H3FN2O2
Weight Average: 130.0772
Monoisotopic: 130.017855555
Protein binding

8-12%

Groups Approved
Therapeutic Class Cytotoxic Chemotherapy
Manufacturer
Available Country Portugal
Last Updated: September 19, 2023 at 7:00 am
Cinkef-U
Cinkef-U

Uses

5-Cinkef-U is used alone or in combination for carcinoma of the colon or rectum, carcinoma of the stomach and exocrine pancreas, carcinoma of the liver, carcinoma of the breast (an especially aggressive form of breast cancer), carcinoma of the bladder, carcinoma of the lung, epithelial ovarian carcinoma andcervical carcinoma.

Cinkef-U is also used to associated treatment for these conditions: Actinic Keratosis (AK), Breast Cancer, Malignant Neoplasm of Colon, Malignant Neoplasm of Pancreas, Malignant Neoplasm of Stomach, Rectal Carcinoma, Superficial Basal Cell Carcinoma, Warts, Hyperkeratotic actinic keratosis

How Cinkef-U works

The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (FdUMP) and the folate cofactor, N5–10-methylenetetrahydrofolate, to thymidylate synthase (TS) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of DNA and RNA synthesis and cell death. Cinkef-U can also be incorporated into RNA in place of uridine triphosphate (UTP), producing a fraudulent RNA and interfering with RNA processing and protein synthesis.

Dosage

Cinkef-U dosage

Various protocols exist-

  • 500 mg/m2 IV on Days 1-5, OR
  • 450-600 mg/m2 IV weekly, OR
  • 200-400 mg/m2 IV continuous infusion qD
  • Not to exceed 800 mg/day

The commonest schedules being 500 mg/m2 daily for 5 days repeated at 4-weekly intervals.

Intravenous 5-FU can be delivered by rapid intravenous bolus injection or slow infusion. The vial contents can rapidly be injected directly into a peripheral vein. Slow intravenous infusion requires the drug to be diluted in 500 mL of dextrose 5% solution, then infused over 2-3 hours on 5 successive days.

Side Effects

Mild to moderate cardiac effects, hepatic effects, hematological effects, neurological effects, allergic reaction, decreased bone marrow function, hand-foot syndrome, severe vomiting, diarrhoea, frequent bowel movements or watery stools, sores in the mouth or throat may occur.

Toxicity

LD50=230mg/kg (orally in mice)

Precaution

Dose should be reduced in patients with compromised liver function. For intra-arterial infusion, 5000 U of L.M. heparin should be added to 1 L of 5% dextrose in water together with the daily dose of fluorouracil. Ulcer-like pain or other significant gastrointestinal symptoms are indications to discontinue intra-arterial therapy, as hemorrhage or perforation may occur. Precipitation may occur when leucovorin and fluorouracil are mixed in the same bag.

Interaction

Pre-treatment with cimetidine for 4 weeks lead to increased plasma concentrations of fluorouracil following intravenous and oral administration. The effect was probably due to a combination of hepatic enzyme inhibition and reduced hepatic blood flow.

Its use should be avoided in patients receiving drugs known to modulate dihydropyrimidine dehydrogenase (such as the antiviral drug sorivudine). It may also increase the INR and prothrombin times in patients on warfarin. Fluoruracil's efficacy is decreased when used alongside allopurinol which can be used to decrease fluoruracil induced stomatitis through use of allopurinol mouthwash.

Food Interaction

No interactions found.

Cinkef-U multivitamins interaction

[Major] MONITOR CLOSELY: Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU).

The exact mechanism of interaction is unknown.

Although enhancement of 5-FU cytotoxicity may be used to advantage in some cancer patients, increased toxicity should also be considered.

Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil.

In a clinical study consisting of 148 patients with advanced untreated colorectal cancer, weekly administration of 5-FU (600 mg

However, the combination was also more toxic than 5-FU alone, as evidenced by a higher incidence of grade 3 to 4 diarrhea (19.5% versus 8.5%) and conjunctivitis (26.5% versus 5.6%), as well as one recorded toxic death versus none.

No differences in median survival and time to progression were observed between the two groups.

Similar results were observed in another study with capecitabine, a prodrug of 5-FU.

The interaction has also been reported with folic acid.

A published case report describes two patients who were hospitalized for presumed 5-FU toxicity (anorexia, severe mouth ulceration, bloody diarrhea, vaginal bleeding) during concomitant treatment with a multivitamin containing folic acid (0.5 mg in one and 5 mg in the other).

Both patients tolerated subsequent courses of 5-FU at the previous dosage following discontinuation of the multivitamin.

Another published report describes a breast cancer patient who died during treatment with capecitabine (2500 mg

The patient developed diarrhea, vomiting, and hand-foot syndrome eight days after starting capecitabine therapy.

Her condition improved briefly following discontinuation of capecitabine and then folic acid, but she subsequently developed necrotic colitis and died from septic shock and vascular collapse.

Caution is advised if 5-FU or any of its prodrugs (e.g., capecitabine, tegafur) are prescribed in combination with leucovorin.

A lower dosage of 5-FU or the prodrug may be required.

Therapy with leucovorin and fluorouracil should not be initiated or continued in patients with symptoms of gastrointestinal toxicity until such symptoms have resolved.

Closely monitor patients with diarrhea until it resolves.

Monitor for other potential toxicities of 5-FU such as neutropenia, thrombocytopenia, stomatitis, cutaneous reactions, and neuropathy.

Patients should be instructed to avoid taking folic acid supplementation or multivitamin preparations containing folic acid without first speaking with their physician.

Elimination Route

28-100%

Half Life

10-20 minutes

Elimination Route

Seven percent to 20% of the parent drug is excreted unchanged in the urine in 6 hours; of this over 90% is excreted in the first hour. The remaining percentage of the administered dose is metabolized, primarily in the liver.

Pregnancy & Breastfeeding use

Pregnancy category D. There are no data on the excretion of fluorouracil into human milk. Because fluorouracil inhibits DNA, RNA and protein synthesis, mothers should not nurse while receiving this drug.

Contraindication

It is contraindicated in patients that are severely debilitated or in patients with bone marrow suppression due to either radiotherapy or chemotherapy. It is likewise contraindicated in pregnant or breastfeeding women. It should also be avoided in patients that do not have malignant illnesses.

Acute Overdose

There is very little difference between the minimum effective dose and maximum tolerated dose of 5-FU, and the drug exhibits marked individual pharmacokinetic variability. Therefore, an identical dose of 5-FU may result in a therapeutic response with acceptable toxicity in some patients and unacceptable and possibly life-threatening toxicity in others. Both overdosing and underdosing are of concern with 5-FU, although several studies have shown that the majority of colorectal cancer patients treated with 5-FU are underdosed based on today's dosing standard, body surface area (BSA). The limitations of BSA-based dosing prevent oncologists from being able to accurately titer the dosage of 5-FU for the majority of individual patients, which results in sub-optimal treatment efficacy or excessive toxicity.

Numerous studies have found significant relationships between concentrations of 5-FU in blood plasma and both desirable or undesirable effects on patients. Studies have also shown that dosing based on the concentration of 5-FU in plasma can greatly increase desirable outcomes while minimizing negative side effects of 5-FU therapy. One such test that has been shown to successfully monitor 5-FU plasma levels and which "may contribute to improved efficacy and safety of commonly used 5-FU-based chemotherapies" is the My 5-FU test.

Storage Condition

Product should be stored below 25℃, without freezing and protected from light.

Innovators Monograph

You find simplified version here Cinkef-U

Cinkef-U contains Fluorouracil see full prescribing information from innovator Cinkef-U Monograph, Cinkef-U MSDS, Cinkef-U FDA label

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:46345
http://metacyc.org/META/new-image?type=COMPOUND&object=CPD0-1327
http://www.hmdb.ca/metabolites/HMDB0014684
http://www.genome.jp/dbget-bin/www_bget?drug:D00584
http://www.genome.jp/dbget-bin/www_bget?cpd:C07649
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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=46345
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL185
https://zinc.docking.org/substances/ZINC000038212689
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000829
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http://www.rxlist.com/cgi/generic3/carac.htm
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https://en.wikipedia.org/wiki/Fluorouracil
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