Cisatracurium besylate
Cisatracurium besylate Uses, Dosage, Side Effects, Food Interaction and all others data.
Cisatracurium besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration. Cisatracurium besylate acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. The neuromuscular block produced by cisatracurium besylate is readily antagonized by anticholinesterase agents once recovery has started. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at the time of reversal, the longer the time required for recovery of neuromuscular function. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action.
Cisatracurium besylate Besylate is a nondepolarizing skeletal muscle relaxant for intravenous administration. Cisatracurium besylate Besylate acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. The neuromuscular block produced by cisatracurium besylate is readily antagonized by anticholinesterase agents once recovery has started. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at the time of reversal, the longer the time required for recovery of neuromuscular function. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action.
| Trade Name | Cisatracurium besylate |
| Availability | Prescription only |
| Generic | Cisatracurium |
| Related Drugs | lorazepam, diazepam, fentanyl, Ativan, lidocaine, Valium, ketamine, midazolam, hyoscyamine, propofol |
| Type | Intravenous |
| Formula | C53H72N2O12 |
| Weight | Average: 929.16 Monoisotopic: 928.507428607 |
| Protein binding | The binding of cisatracurium to plasma proteins has not been successfully studied due to its rapid degradation at physiologic pH. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cisatracurium besylate is a skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation.
For inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU.
Cisatracurium besylate is also used to associated treatment for these conditions: General Anesthesia, Skeletal muscle relaxation for mechanical ventilation, Smooth muscle relaxation prior to radiological procedures
How Cisatracurium besylate works
Cisatracurium besylate Besylate binds to the nicotinic acetycholine (cholinergic) receptors in the motor endplate and blocks access to the receptors. In the process of binding, the receptor is actually activated - causing a process known as depolarization. Since it is not degraded in the neuromuscular junction, the depolarized membrane remains depolarized and unresponsive to any other impulse, causing muscle paralysis.
Toxicity
Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.
Food Interaction
No interactions found.Cisatracurium besylate Drug Interaction
Moderate: digoxin, digoxinUnknown: aspirin, aspirin, charcoal, charcoal, epinephrine, epinephrine, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, ubiquinone, ubiquinone, copper gluconate, copper gluconate, glycerin, glycerin, acetaminophen, acetaminophen, bioflavonoids, bioflavonoids
Cisatracurium besylate Disease Interaction
Major: prematurity, burns, myasthenia gravis, paresis, pulmonary impair
Half Life
Elimination half-life of 22 minutes.
Elimination Route
Biliary and urinary excretion were the major routes of excretion of radioactivity (totaling >90% of the labeled dose within 7 hours of dosing), of which atracurium represented only a minor fraction.
Innovators Monograph
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