Citizine
Citizine Uses, Dosage, Side Effects, Food Interaction and all others data.
Citizine is a naturally occurring, water-soluble biological compound that is essential intermediate for the synthesis of phosphatidylcholine, a major constituent of the gray matter of brain tissue. Citizine promotes brain metabolism by enhancing the synthesis of acetylcholine and restoring phospholipid content in the brain. It also elevates brain oxygen consumption and improves brain metabolism. Citizine seems to increase a brain chemical called phosphatidylcholine. This brain chemical is important for brain function. Citizine might also decrease brain tissue damage when the brain is injured.
| Trade Name | Citizine |
| Availability | Over the counter |
| Generic | Citicoline |
| Citicoline Other Names | CDP-choline, CDP-colina, citicolina, Citicoline, citidin difosfato de colina |
| Type | Tablet |
| Formula | C14H26N4O11P2 |
| Weight | Average: 488.324 Monoisotopic: 488.107330718 |
| Groups | Approved, Experimental |
| Therapeutic Class | CNS stimulant drugs |
| Manufacturer | Zee Laboratories Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Use for the improvement of thinking, learning and memory in people suffering from Alzheimer's disease, dementia, head trauma, Parkinson's disease and glaucoma. Also used in loss of consciousness due to brain damage, head injury or brain surgery and cerebral infarction, age-related memory problems and stroke.
Citizine is also used to associated treatment for these conditions: Degenerative Brain Disorder, Parkinsonian Syndromes
Dosage
Citizine dosage
Disturbance of Consciousness: Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily.
Psychologic or Neurologic Disorders: Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once daily for 2 consecutive weeks or as prescribed by the physician.
Side Effects
Rash, Insomnia, headache, dizziness, convulsion, Nausea, anorexia, Abnormal liver function in laboratorium measurement, Diplopia, Flushing, transient blood pressure changes or malaise.
Precaution
In acute and emergency condition, citicoline should be administered. In conjunction with intracranial pressure-relieving drugs or homostatic and treatment eg, hypothermy. If intracranial bleeding continue, avoid giving high-dose citicoline (>500 mg concomitantly), since it may exaggerate blood flow in brain. In case small dose of citicoline (100-500 mg 2-3 times daily) may be needed.
Precaution should be given in patients with hypersensitivity. For patients with disturbance of consciousness in acute stage of cerebral infarction, start of citicoline injection recommended within 2 weeks after apoplectic stroke.
Use in pregnancy: Citizine is avoided in pregnancy.
Use in lactation: Citizine is avoided by nursing mothers.
Interaction
Zynapse potentiates the effects of L-dopa.
Pregnancy & Breastfeeding use
There is inadequate evidence of safe use of citicoline in human pregnancy. Citizine should be used in pregnancy and lactation only if the potential benefits justify the potential risks.
Contraindication
Hypersensitivity to citicoline sodium or to any of the excipients of Citizine.
Storage Condition
Store below 25° C
Innovators Monograph
You find simplified version here Citizine
FAQ
What is Citizine used for?
Citizine used to treat traumatic brain injures, stroke, vascular dementia, Parkinson's disease, and brain aging where it has the function of stabilizer of cell membranes and reduces the presence of free radicals. Citizine help memory loss due to aging, improve vision in people with glaucoma, and help with recovery in stroke patients. It is also used for Alzheimer disease, bipolar disorder, lazy eye, and other conditions of the brain.
How safe is Citizine?
No serious safety issues have been reported with citicoline treatment. In fact, in a meta-analysis of trials for cerebral dysfunction in elderly people, citicoline tended to be more tolerable than the placebo. However, the safety of long-term Citizine citicoline supplementation is not known.
What are the common side effects of Citizine?
Common side effects of Citizine such as trouble sleeping, headache, constipation, diarrhea, nausea, stomach pain, blurred vision, chest pains, and others.
Is Citizine safe during pregnancy?
Women who are pregnant should avoid using Citizine.
Is Citizine safe during breastfeeding?
There isn't enough reliable information to know if Citizine is safe to use when breast-feeding. Stay on the safe side and avoid use.
When should be taken of Citizine?
Stroke patients who take Citizine by mouth or by IV within 24 hours of having the kind of stroke that is caused by a clot (ischemic stroke) may be more likely to have a complete recovery within 3 months.
Is Citizine taken with food?
May be taken with or without food.
How much Citizine can I take daily?
Oral dosages of 250 to 2,000 mg daily have been evaluated in adolescents and adults in clinical trials. Lower doses have been used in short-term trials with combination therapy in patients with major depressive disorder.
How long does it take Citizine to work?
Citizine administration of at least 6 months.
Does Citizine help memory?
According to the present results, showing that Citizine improves memory performance in elderly subjects, we concluded that this molecule is suitable for the treatment of memory deficits in old people.
How long does Citizine take to work?
Some people will notice results in as little as 3 to 5 days, but most users will see results in no later than 15 days.
How long does Citizine take to work?
Elimination half-life of citicoline is 3.5 hrs (1st peak concentration), 125 hrs (2nd peak concentration).
How long is Citizine taken?
Citizine possibly safe when taken by mouth short-term (up to 90 days).
How should I take Citizine?
Citizine is taken by mouth as a supplement or given as an injection into the vein (by IV) or as a shot into the muscle.
Who should not take Citizine?
Do not take Citizine if you have any known allergy to Citizine or any other psychostimulant drugs. Inform your doctor if you are taking any prescription or non-prescription drugs, nutritional supplements, or herbal products. Inform your doctor if you are pregnant or breastfeeding.
Can I take Citizine for a long time?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
What happen If I missed dose of Citizine?
Try not to skip a dose of Citizine. If a dose is skipped, do not add it up to the next dose. Since Citizine is administered in a hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.
What happens if I overdose of Citizine?
Seek emergency medical treatment or contact your doctor in case of an overdose. Since Citizine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.
Can Citizine affect my kidneys?
Use Citizine with caution if you have kidney problems. Impaired kidney function may lead to slow elimination and accumulation of this medicine in your body. Your doctor may prescribe a suitable dose based on your health condition.
Can Citizine affects my liver?
Use Citizine with caution if you have liver problems. In such cases, using a higher dose of this medicine is not recommended.
