Citopan

Citopan Uses, Dosage, Side Effects, Food Interaction and all others data.

A barbiturate that is effective as a hypnotic and sedative.

Citopan is a barbiturate derivative having hypnotic and sedative effects. It was subsequently used in the 1940s and 1950s as an anesthetic for surgery. Furthermore, the agent also demonstrates a fairly quick onset of action that also possesses a short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days.

Trade Name Citopan
Generic Hexobarbital
Hexobarbital Other Names Hexobarbital, Hexobarbitone, Methexenyl, Methylhexabital
Type
Formula C12H16N2O3
Weight Average: 236.267
Monoisotopic: 236.116092388
Protein binding

25%

Groups Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Citopan
Citopan

Uses

For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.

How Citopan works

Citopan binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.

Innovators Monograph

You find simplified version here Citopan

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000002
http://classyfire.wishartlab.com/tax_nodes/C0001346
http://classyfire.wishartlab.com/tax_nodes/C0000075
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http://classyfire.wishartlab.com/tax_nodes/C0003633
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5706
http://www.hmdb.ca/metabolites/HMDB0015444
http://www.genome.jp/dbget-bin/www_bget?drug:D01071
http://www.genome.jp/dbget-bin/www_bget?cpd:C11723
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3608
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508777
https://www.chemspider.com/Chemical-Structure.3482.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=5302
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=5706
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL7728
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000688
http://www.pharmgkb.org/drug/PA449875
https://en.wikipedia.org/wiki/Hexobarbital
*** Taking medicines without doctor's advice can cause long-term problems.
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