Citrate of Betaine

Citrate of Betaine Uses, Dosage, Side Effects, Food Interaction and all others data.

Citrate of Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine and reduces homocystinuria in patients with inborn errors of methionine metabolism. In the United States, betaine is distributed under the brand name Cystadane® by Rare Disease Therapeutics. Many reports have shown that betaine's therapeutic effectiveness is limited, and does not lower tHcy levels or prevent clinical symptoms [2].

Trade Name Citrate of Betaine
Availability Prescription only
Generic Betaine
Betaine Other Names 2-trimethylammonioacetate, Abromine, Acidol, Betaína anhidra, Betaine, Glycine betaine, Glycinebetaine, Glykokollbetain, N,N,N-Trimethylglycine, Trimethylaminoacetate, Trimethylammonioacetate, Trimethylglycine
Type
Formula C5H11NO2
Weight Average: 117.1463
Monoisotopic: 117.078978601
Groups Approved, Nutraceutical
Therapeutic Class
Manufacturer
Available Country Lithuania
Last Updated: September 19, 2023 at 7:00 am
Citrate of Betaine
Citrate of Betaine

Uses

Citrate of Betaine is a methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels.

Citrate of Betaine is indicated for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Included within the category of homocystinuria are deficiencies or defects in: 1. cystathionine beta-synthase (CBS), 2. 5,10-methylenetetrahydrofolate reductase (MTHFR), 3. cobalamin cofactor metabolism (cbl).

Citrate of Betaine is also used to associated treatment for these conditions: Homocystinuria

How Citrate of Betaine works

Citrate of Betaine acts as a methyl group donor in the remethylation of homocysteine to methionine in patients with homocystinuria.

Toxicity

In an acute toxicology study in rats, death frequently occurred at doses equal to or greater than 10,000 mg/kg.

Food Interaction

  • Take with or without food. Oral betaine powder should be mixed with food or a beverage and then consumed.

Volume of Distribution

V/F = 1.3 l/kg

Elimination Route

After a single oral dose of betaine (50 mg/kg), absorption was rapid (tmax = 0.9 ± 0.3 hours and a Cmax = 0.9 ± 0.2 mM).

Half Life

14 hours

Clearance

84 ml/h/kg

Innovators Monograph

You find simplified version here Citrate of Betaine

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http://classyfire.wishartlab.com/tax_nodes/C0001831
http://classyfire.wishartlab.com/tax_nodes/C0002449
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17750
http://metacyc.org/META/new-image?type=COMPOUND&object=BETAINE
http://www.hmdb.ca/metabolites/HMDB0000043
http://www.genome.jp/dbget-bin/www_bget?drug:D07523
http://www.genome.jp/dbget-bin/www_bget?cpd:C00719
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=247
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264879
https://www.chemspider.com/Chemical-Structure.242.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103520
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1512
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=17750
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1182
https://www.drugs.com/pro/cystadane.html
https://en.wikipedia.org/wiki/Trimethylglycine
*** Taking medicines without doctor's advice can cause long-term problems.
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