Ciza Mps

Ciza Mps Uses, Dosage, Side Effects, Food Interaction and all others data.

In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients.

Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist; upon activation of the receptor signaling pathway, cisapride promotes the release of acetylcholine neurotransmitters in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.

Trade Name Ciza Mps
Generic Cisapride + Simeticone
Type Tablet
Therapeutic Class
Manufacturer Intas Pharmaceuticals Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Ciza Mps
Ciza Mps

Uses

Cisapride is a medication used to treat heartburn associated with GERD.

For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.

Ciza Mps is also used to associated treatment for these conditions: Gastrointestinal Disorder

How Ciza Mps works

Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). This results in increased tone and amplitude of gastric (especially antral) contractions, relaxation of the pyloric sphincter and the duodenal bulb, and increased peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit.

Elimination Route

Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.

Half Life

6-12 hours

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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