Clearmox Dt
Clearmox Dt Uses, Dosage, Side Effects, Food Interaction and all others data.
Amoxycillin is a semi-synthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Amoxycillin is bactericidal against susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptides.
Clearmox Dt competitively inhibit penicillin binding proteins, leading to upregulation of autolytic enzymes and inhibition of cell wall synthesis. Clearmox Dt has a long duration of action as it is usually given twice daily. Clearmox Dt has a wide therapeutic range as mild overdoses are not associated with significant toxicity. Patients should be counselled regarding the risk of anaphylaxis, Clostridium difficile infections, and bacterial resistance.
| Trade Name | Clearmox Dt |
| Availability | Prescription only |
| Generic | Amoxicillin |
| Amoxicillin Other Names | Amox, Amoxicilina, Amoxicillin, Amoxicilline, Amoxicillinum, Amoxycillin, p-Hydroxyampicillin |
| Related Drugs | prednisone, omeprazole, albuterol, pantoprazole, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin |
| Type | |
| Formula | C16H19N3O5S |
| Weight | Average: 365.404 Monoisotopic: 365.104541423 |
| Protein binding | Amoxicillin is 17% protein bound in serum. |
| Groups | Approved, Vet approved |
| Therapeutic Class | Broad spectrum penicillins |
| Manufacturer | Indoco Remedies Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Clearmox Dt is used for the treatment of the following bacterial infections when caused by susceptible organisms:
- Respiratory tract, ENT infections: Acute and chronic bronchitis, pneumonia, otitis media, sinusitis, tonsillitis, pharyngitis & laryngitis, lobar & bronchopneumonia, chronic bronchial sepsis.
- Urinary tract infections: Pyelonephritis, cystitis and urethritis.
- Obstetric & gynaecological infections: Bacteriuria in pregnancy, septic abortion, intra-abdominal sepsis and puerperal sepsis.
- Gastro-intestinal infections: Typhoid and paratyphoid.
- Skin & soft tissue infections: Cellulitis, infected wounds and abscesses.
- Generalized infections: Septicemia, bacterial endocarditis, meningitis, peritonitis and osteomyelitis.
- Venereal infections: Gonorrhea and syphilis. Clearmox Dt may also be used as prophylactic cover for patients at risk of developing endocarditis when undergoing dental surgery.
Clearmox Dt is also used to associated treatment for these conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media, Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary infections, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections
How Clearmox Dt works
Clearmox Dt competitively inhibits penicillin-binding protein 1 and other high molecular weight penicillin binding proteins. Penicillin bind proteins are responsible for glycosyltransferase and transpeptidase reactions that lead to cross-linking of D-alanine and D-aspartic acid in bacterial cell walls. Without the action of penicillin binding proteins, bacteria upregulate autolytic enzymes and are unable to build and repair the cell wall, leading to bacteriocidal action.
Dosage
Clearmox Dt dosage
Ear/Nose/ThroatInfection (Mild to Moderate):
- Adult:500 mg every 12 hours or 250 mg every 8 hours
- Children:25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours
Ear/Nose/ThroatInfection (Severe):
- Adult: 875 mg every 12 hours or 500 mg every 8 hours
- Children: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Lower respiratory tractInfection (Mild/ Moderate/Severe):
- Adult: 875 mg every 12 hours or 500 mg every 8 hours
- Children: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Skin/skin structureInfection (Mild/Moderate):
- Adult: 500 mg every 12 hours or 250 mg every 8 hours
- Children: 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours
Skin/skin structureInfection (Severe):
- Adult: 875 mg every 12 hours or 500 mg every 8 hours
- Children: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Genitourinary tractInfection (Mild/ Moderate):
- Adult: 500 mg every 12 hours or 250 mg every 8 hours
- Children: 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours
Genitourinary tractInfection (Severe):
- Adult: 875 mg every 12 hours or 500 mg every 8 hours
- Children: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Gonorrhea, Acute, uncomplicated ano-genital, and urethral infections in males and females:
- Adult: 3 g as single oral dose
- Prepubertal children: 50 mg/Kg/Amoxycillin, combined with 25 mg/kg Probenecid as a single dose. Since Probenecid is contraindicated in children under 2 years, do not use this regimen in these cases.
Suspension: Shake the bottle well before adding water. Then add 12 tea spoonful (60 ml) of boiled and cooled water to the bottle and shake well to make 100 ml suspension.
Amoxycillin 500 mg Injection:
- Intramuscular : Add 2.5 ml water for injection to Amoxycillin 500 mg injection vial.
- Intravenous : Dissolve Amoxycillin 500 mg injection in 10 ml water for injection.
Side Effects
Side effects are mild, rare and infrequent. As with other penicillins, it may induce diarrhea, indigestion or skin rashes that usually stop during treatment and rarely calls for discontinuation of therapy.
Toxicity
Patients experiencing an overdose may present with hematuria, oliguria, abdominal pain, acute renal failure, vomiting, diarrhea, rash, hyperactivity, and drowsiness. Treat overdose with symptomatic and supportive treatment, which may include emesis or hemodialysis.
Precaution
In renal impairment, the excretion of antibiotic will be delayed and depending on the degree of impairment it may be necessary to reduce the total daily dose.
Interaction
The simultaneous use of Clearmox Dt and an oral contraceptive might cause breakthrough bleeding or pregnancy on rare occasions. Concurrent administration of probenecid delays the excretion of Clearmox Dt.
Food Interaction
- Take with food.
Clearmox Dt Drug Interaction
Unknown: aspirin, aspirin, diphenhydramine, diphenhydramine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, acetaminophen / hydrocodone, acetaminophen / hydrocodone, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, alprazolam, alprazolam, cetirizine, cetirizine
Clearmox Dt Disease Interaction
Major: colitisModerate: mononucleosis, diabetes, renal dysfunction, hemodialysis
Volume of Distribution
The central volume of distribution of amoxicillin is 27.7L.
Elimination Route
Clearmox Dt is approximately 60% bioavailable. A 250mg dose of oral amoxicillin reaches a Cmax 3.93±1.13mg/L with a Tmax 1.31±0.33h and an AUC of 27.29±4.72mg*h/L. A 875mg dose of oral amoxicillin reaches a Cmax 11.21±3.42mg/L with a Tmax 1.52±0.40h and an AUC of 55.04±12.68mg*h/L.
Half Life
The half life of amoxicillin is 61.3 minutes.
Clearance
The mean clearance of amoxicillin is 21.3L/h.
Elimination Route
125mg to 1g doses of amoxicillin are 70-78% eliminated in the urine after 6 hours.
Pregnancy & Breastfeeding use
Because of its lack of teratogenicity, Clearmox Dt can beused safely throughout pregnancy at the normal adult dose. The small amount of Clearmox Dt secreted in maternal milk rarely causes problem in the infant. It can therefore be used safely during lactation in most instances.
Contraindication
Clearmox Dt is contraindicated for patients hypersensitive to penicillin, infectious mononucleosis, neonatal period or babies born of mothers hypersensitive to penicillin
Acute Overdose
If encountered, gastro-intestinal symptoms and disturbance of the fluid and electrolyte balance may be evident. They may be treated symptomatically and supportive with attention to the water/ electrolyte balance. In the absence of an adequate fluid intake and urinary output, crystalluria is a possibility and the antibiotic may be removed from the circulation by haemodialysis. Oral administration can cause gastro intestinal symptoms such as transient diarrhoea, nausea and colic which are dose related and a result of local irritation not toxicity.
Storage Condition
Store in a cool & dry place protected from light. Clearmox Dt suspension and drops should be freshly prepared, stored in a cool dry place preferably in a refrigerator. Reconstituted suspension and drops should be used within 5 days if kept at room temperature or within 7 days if kept in a refrigerator.
Innovators Monograph
You find simplified version here Clearmox Dt
Clearmox Dt contains Amoxicillin see full prescribing information from innovator Clearmox Dt Monograph, Clearmox Dt MSDS, Clearmox Dt FDA label
FAQ
What is Clearmox Dt used for?
Clearmox Dt is used to treat bacterial infections, such as chest infectionsand dental abscesses.
How safe is Clearmox Dt?
Clearmox Dt is a safe and affordable antibiotic; however, it is not the right antibiotic for all infections. It is important not to share your antibiotics with anyone. An antibiotic is prescribed specifically for you and your particular type of bacterial infection.
How does Clearmox Dt work?
Clearmox Dt work by binding proteins and inhibiting certain processes in bacterial cells.
What are the common side effects of Clearmox Dt?
The most common side effects of Clearmox Dt are feeling sick and diarrhoea. Liquid Clearmox Dt can stain your teeth. This does not last and is removed by brushing. You can drink alcohol while taking Clearmox Dt.
Is Clearmox Dt safe during pregnancy?
Clearmox Dt is in the penicillin family of antibiotics. Some antibiotics are safe to take during pregnancy, while others are not.Clearmox Dt is considered a pregnancy category B drug by the U.S. Food and Drug Administration. That means it’s considered safe to take while pregnant. it's considered safe to take while pregnant.
Is Clearmox Dt safe during breastfeeding?
Clearmox Dt is used to treat infections in babies and it can be used by women who are breastfeeding.Clearmox Dt passes into breast milk and although this is unlikely to have any harmful effects on a nursing infant, it could theoretically affect the natural bacteria found in the baby's mouth or gut.
Can I drink alcohol with Clearmox Dt?
Yes, you can drink alcohol while taking the antibiotic Clearmox Dt. The alcohol will not stop Clearmox Dt from working. However, many health professionals will recommend you avoid alcohol to give your body the best chance possible to fight the infection.
Can I drive after taking Clearmox Dt ?
Clearmox Dt can have side effects and the symptoms may make you unfit to drive. Do not drive or operate machinery unless you are feeling well.
When should be taken of Clearmox Dt?
Clearmox Dt is usually taken every 12 hours or every 8 hours with or without food. The length of your treatment depends on the type of infection that you have. Take Clearmox Dt at around the same times every day.
Should Clearmox Dt be taken on an empty stomach?
Take this medicine by mouth with a glass of water. Follow the directions on your prescription label.You can take it with or without food. If it upsets your stomach, take it with food.
Can I take Clearmox Dt once a day?
Clearmox Dt is ideal for once-daily dosing due to its low cost.
How long should Clearmox Dt take to work?
Clearmox Dt begins to work quickly after a patient takes it, and it reaches peak blood concentrations in about one or two hours, according to the drug's label. However, improvement in symptoms will take longer.
How long do Clearmox Dt stay in my system?
After taking an oral dose of Clearmox Dt, 60% of it will be out of your system in 6 to 8 hours.
Can I take Clearmox Dt for a long time?
A person may take antibiotics for a long time for severe or continued infections, such as osteomyelitis. Doing so puts them at higher risk of long-term complications , including crystalluria, hemolytic anemia, and nephritis.
How long can I take Clearmox Dt?
Clearmox Dt also depends on the type of infection you're treating. Most antibiotics should be taken for 7 to 14 days.
How should not take Clearmox Dt?
You should not use Clearmox Dt if you are allergic to any penicillin antibiotic, such as Clearmox Dt.
What happens if I miss a dose of Clearmox Dt?
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
Can Clearmox Dt effects my fertility?
Antibiotics affect both the quantity and quality of sperm. They may reduce the number of sperm a man produces, and make the sperm he does produce swim more slowly.
What happen if I overdose on Clearmox Dt?
Antibiotic overdoses are rarely dangerous, but stomach upset and diarrhea may occur. Taking the wrong antibiotic is a problem if someone is allergic to the drug.
Does Clearmox Dt make sleepy?
If you're taking prescription Clearmox Dt, you may feel tired and fatigued.
Can I take Clearmox Dt before bed?
It is generally not a good idea to take these medications right before bedtime.
Do Clearmox Dt weaken my immune system?
Very rarely, antibiotic treatment will cause a drop in the blood count, including the numbers of white cells that fight infection. This corrects itself when the treatment is stopped.
Do Clearmox Dt affect the liver?
Clearmox Dt are a common cause of drug-induced liver injury.
