Clidinorm

Clidinorm Uses, Dosage, Side Effects, Food Interaction and all others data.

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.

Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.

Mebeverine is a musculotropic antispasmodic agent used to relieve cramps or spasms of the stomach and intestine (gut). It is particularly useful in treating Irritable Bowel Syndrome (IBS) and similar conditions. It works by relaxing the muscles and helping to restore the normal movement of the gut.

Clidinorm
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Clidinorm
Generic	Mebeverine + Chlordiazepoxide
Weight	135mg
Type	Tablet
Therapeutic Class
Manufacturer	Sargas Life Sciences
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Chlordiazepoxide is a benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period.

For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.

For the symptomatic treatment of Irritable Bowel Syndrome (IBS) and other conditions include:

Chronic irritable colon
Spastic constipation
Mucous colitis
Colicky abdominal pain
Persistent non-specific diarrhea

Clidinorm is also used to associated treatment for these conditions: Alcohol Withdrawal Syndrome, Anxiety, Anxiety Disorders, Depression, Peptic Ulcer Disease, Acute Anxiety, Pyschosomatic diseaseAbdominal Pain, Abdominal Spasms, Abnormal Bowel Movement Such as Constipation, Diarrhea, Abdominal Pain, Irritable Bowel Syndrome (IBS), Bowel discomfort

How Clidinorm works

Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor. BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.

Dosage

Clidinorm dosage

135 mg tid, may reduce gradually after several wk when the desired effect has been obtained; 100 mg tid has also been used. As modified-release cap: 200 mg bid.

Mebeverine is most effective when taken 20 minutes before meals. After several weeks when the desired effect has been obtained, the dosage may be gradually reduced.

Missed dose: If a dose of this medicine is missed, that should be taken as soon as possible. However, if it is almost time for the next dose, then skip the missed dose and the regular dosing schedule should be maintained. Dose should not be doubled at the same time to compensate the missed dose.

Side Effects

Generally Mebeverine is well tolerated. However, few side-effects like skin rash, urticaria and angioedema may appear.

Toxicity

LD₅₀=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).

Precaution

Caution should be exercised in porphyria or allergic reaction to this or any other medicine of this group.

Half Life

24-48 hours

Elimination Route

Chlordiazepoxide is excreted in the urine, with 1% to 2% unchanged and 3% to 6% as conjugate.

Pregnancy & Breastfeeding use

No teratogenicity has been shown in animal experiments. However, the usual precautions concerning the administration of any drug during pregnancy should be exercised. Mebeverine does not excrete in the breast milk after administering the therapeutic dose.

Special Warning

Use in children: Mebeverine is not recommended in children under 10 years.

Acute Overdose

Symptoms: CNS excitability

Management: Symptomatic and supportive treatment. Gastric lavage may be considered in case of multiple intoxication or if discovered w/in approx 1 hr.