Clindoxyl
Clindoxyl Uses, Dosage, Side Effects, Food Interaction and all others data.
Clindamycin is a semi-synthetic derivative of lincomycin. It inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunits thus blocking the transpeptidation or translocation reactions of susceptible organisms.
Benzoyl peroxide has mild keratolytic effect and antimicrobial activity which is attributed to its potent oxidizing activity. Clindamycin and Benzoyl peroxide are both active against Propionibacterium acnes, an organism associated with acne vulgaris.
| Trade Name | Clindoxyl |
| Generic | Clindamycin + Benzoyl peroxide |
| Type | |
| Therapeutic Class | Benzoyl peroxide, Azelaic acid & other preparations |
| Manufacturer | |
| Available Country | Canada, United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Indicated in acne vulgaris.
Clindoxyl is also used to associated treatment for these conditions: Acne, Acne Vulgaris, Inflammatory Acne VulgarisAbscess, Intra-Abdominal caused by Anaerobic Bacterial Infection, Acne Vulgaris, Babesiosis, Bacterial Endocarditis, Bacterial Vaginosis (BV), Bloodstream Infections caused by Anaerobic Bacterial Infection, Bone and Joint Infections caused by susceptible Staphylococcus, Empyema caused by Anaerobic Bacterial Infection, Endometritis caused by Anaerobic Bacterial Infection, Lung Abscess caused by Anaerobic Bacterial Infection, Malaria caused by Plasmodium falciparum, Mixed Vaginal Infections, Pelvic cellulitis caused by Anaerobic Bacterial Infection, Peritonitis caused by Anaerobic Bacterial Infection, Pneumocystis Jirovecii Pneumonia, Pneumonitis caused by Anaerobic Bacterial Infection, Respiratory Tract Infections (RTI) caused by susceptible Staphylococcus, Respiratory Tract Infections (RTI) caused by susceptible pneumococci, Respiratory Tract Infections (RTI) caused by susceptible streptococci, Skin Structures and Soft Tissue Infections caused by Anaerobic Bacterial Infection, Skin Structures and Soft Tissue Infections caused by susceptible Staphylococcus, Skin Structures and Soft Tissue Infections caused by susceptible streptococci, Toxoplasmosis, Tubo-ovarian abscess caused by Anaerobic Bacterial Infection, Vaginal Candidiasis, Vaginal Mycosis, Chronic Bone and Joint Infections caused by Susceptible infections, Moderate Acne vulgaris, Post-surgical vaginal cuff infection caused by Anaerobic Bacterial Infection, Viridans group streptococci
How Clindoxyl works
Acne vulgaris is caused by inflammation in the pilosebaceous gland. Acne is generally caused by increased excretion of sebum from pilosebaceous glands, endocrine factors such as androgenic hormones, keratin developing around follicles, bacterial growth, and inflammation. These factors contribute to the formation of comedones (whiteheads and blackheads).
The peroxide bond of benzoyl peroxide is cleaved to form 2 benzoyloxy radicals. These radicals interact nonspecifically with bacterial proteins, interfering with their function, and survival of the bacteria. Over time, free radical interactions with bacterial proteins lead to decreased keratin and sebum around follicles.
Benzoyl peroxide can also increase the turnover rate of epithelial cells, leading to skin peeling, and breaking down comedones.
Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S subunit of the bacterial ribosome. It impedes both the assembly of the ribosome and the translation process. The molecular mechanism through which this occurs is thought to be due to clindamycin's three-dimensional structure, which closely resembles the 3'-ends of L-Pro-Met-tRNA and deacylated-tRNA during the peptide elongation cycle - in acting as a structural analog of these tRNA molecules, clindamycin impairs peptide chain initiation and may stimulate dissociation of peptidyl-tRNA from bacterial ribosomes.
The mechanism through which topical clindamycin treats acne vulgaris is unclear, but may be related to its activity against Propionibacterium acnes, a bacteria that has been associated with acne.
Dosage
Clindoxyl dosage
Apply to the affected areas once or twice daily (morning and evening) after the skin is gently washed and patted dry.
Refer to individual product recommendations. Some combination products require reconstitution at the time of dispensing by dissolving the Clindamycin powder with purified water, add the solution to the Benzoyl peroxide gel provided and stir until the gel appears homogenous.
Side Effects
Application site pain, Application site exfoliation, Application site irritation, Erythema, Burning, Pruritus, Sunburn, Scaling, Drynes, Colitis, Peelin.
Toxicity
Data regarding overdoses of benzoyl peroxide are not readily available. During an overdose patients may experience and increased risk or severity of adverse effects such as skin itching, burning, peeling, inflammation, and erythema.
The oral LD50 in rats is 490 mg/kg.
The oral LD50 in mice and rats is 2540 mg/kg and 2190 mg/kg, respectively.
While no cases of overdose have been reported, symptoms are expected to be consistent with the adverse effect profile of clindamycin and may therefore include abdominal pain, nausea, vomiting, and diarrhea. During clinical trials, one 3-year-old child was given a dose of 100 mg/kg daily for 5 days and showed only mild abdominal pain and diarrhea. Activated charcoal may be of value to remove unabsorbed drug, but hemodialysis and peritoneal dialysis are ineffective. General supportive measures are recommended in cases of clindamycin overdose.
Precaution
Avoid contact with mouth, eyes, lips & mucous membranes; abraded or eczematous skin. May discolor hair & dyed fabrics. Pregnancy & lactation.
Interaction
May enhance the action of neuromuscular blocking agents (e.g. atracurium). May antagonise the effects of parasympathomimetics. May competitively inhibit the effects of macrolides, ketolides, streptogramins, linezolid and chloramphenicol. Increased coagulation tests (prothrombin time/INR) and/or bleeding with vit K antagonists (e.g. warfarin, acenocoumarol, fluindione). PABA sunscreens may transiently discolour fabric.
Volume of Distribution
Clindamycin is widely distributed in the body, including into bone, but does not distribute into cerebrospinal fluid. The volume of distribution has been variably estimated between 43-74 L.
Elimination Route
In a sample of excised skin, 1.9% of a radiolabelled topical dose fully penetrates the skin, and 2.6% remains in the skin. The radiolabelled dose that fully penetrates the skin is recovered as benzoic acid, while the dose in the skin is approximately half benzoic acid and half benzoyl peroxide. 95.5% of a radiolabelled dose is not absorbed or metabolized after 8 hours.
Oral bioavailability is nearly complete, at approximately 90%, and peak serum concentrations (Cmax) of, on average, 2.50 µg/mL are reached at 0.75 hours (Tmax). The AUC following an orally administered dose of 300mg was found to be approximately 11 µg•hr/mL. Systemic exposure from the administration of vaginal suppository formulations is 40-fold to 50-fold lower than that observed following parenteral administration and the Cmax observed following administration of vaginal cream formulations was 0.1% of that observed following parenteral administration.
Half Life
The elimination half-life of clindamycin is about 3 hours in adults and 2.5 hours in children. Half-life is increased to approximately 4 hours in the elderly.
Clearance
The plasma clearance of clindamycin is estimated to be 12.3-17.4 L/h, and is reduced in patients with cirrhosis and altered in those with anemia.
Elimination Route
Benzoyl peroxide's metabolite benzoic acid, is eliminated in the urine. Data regarding fecal elimination is not readily available.
Approximately 10% of clindamycin bioactivity is excreted in the urine and 3.6% in the feces, with the remainder excreted as inactive metabolites.
Pregnancy & Breastfeeding use
Pregnancy Category- C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Lactation: Excretion in milk is unknown/ not recommended
Contraindication
Hypersensitivity to Clindamycin, lincomycin, benzoyl peroxide, or any component of the formulation; history of regional enteritis, ulcerative colitis, pseudomembranous colitis or antibiotic-associated colitis.
Acute Overdose
Benzoyl Peroxide gel is a preparation indicated for topical treatment only. If the medication is applied excessively, no more rapid or better results will be obtained and severe irritation might develop. In this event, treatment must be discontinued and appropriate symptomatic therapy should be instituted.
Overdosage with orally administered clindamycin has been rare. Adverse reactions similar to those seen with normal doses can be expected, however, unexpected reactions could occur. Haemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum. Overdosage should be treated with simple gastric lavage. No specific antidote is known.
Storage Condition
Store in a cool and dry place, protected from light.
Store between 20-25°C. Do not refrigerate or freeze.
Innovators Monograph
You find simplified version here Clindoxyl
FAQ
Is Clindoxyl good for acne?
This combination medication is used to treat a certain type of acne (inflammatory acne vulgaris). Clindoxyl helps to decrease the number of acne pimples.
Is Clindoxyl an antibiotic?
Clindoxyl Gel contains a combination of benzoyl peroxide and clindamycin. Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect that allows excess oil and dirt to be washed away. Clindamycin is an antibiotic that prevents bacteria from growing on the skin.
Is Clindoxyl over the counter?
There are many products on the market to treat facial acne. The medication that this study will be evaluating, Benzaclin and Retin-A have been approved by the FDA and is available by prescription, Clindoxyl is an over the counter product.
How long do I keep Clindoxyl on my face?
You may notice that your acne seems worse for a few weeks after beginning treatment. This is normal, so don't stop using your medication. Stick with treatment for eight to 12 weeks, because it can take that long to notice an improvement.
Do I wash off Clindoxyl?
Clindoxyl Topical Gel should be applied twice daily, morning and evening, or as directed by a physician, to affected areas after the skin is gently washed, rinsed with warm water and patted dry.
What is the cause of acne vulgaris?
Acne vulgaris is a skin condition that occurs when hair follicles are blocked with dead skin cells, bacteria, and oil (sebum). The blocked follicles cause blemishes on the skin, including pimples, blackheads, whiteheads, and cysts.
Can I use moisturizer with Clindoxyl?
If you're just beginning with your benzoyl peroxide treatment, start using moisturizer now, even before you notice any uncomfortable dryness. You may be able to stave off the worst of it. If you've already succumbed to benzoyl peroxide-induced dryness and flakiness, slather on moisturizer as often as necessary.
How do I use Clindoxyl?
Apply a thin layer to the affected area(s) of the skin two times a day (morning and evening).
Does Clindoxyl expire?
Clindoxyl has an expiration date of 3 months.
What does Clindoxyl do?
Benzoyl peroxide has an antibacterial effect. It also has a mild drying effect that allows excess oil and dirt to be washed away. Clindamycin is an antibiotic that prevents bacteria from growing on the skin. Benzoyl peroxide and clindamycin topical (for the skin) is a combination medicine used to treat acne.
How long does it take for Clindoxyl to work?
It may take up to 6 weeks to see a decrease in acne and up to 12 weeks to see the full benefit of the medication.
Is Clindoxyl good for acne?
The takeaway. Topical or oral antibiotics may help reduce acne. Clindamycin is a commonly prescribed topical medication to treat acne, and you can usually apply it with minimal side effects.
How long should I leave Clindoxyl on my face?
Before applying, wash the affected area with a nonmedicated cleanser. Then rinse and pat dry. Using a circular motion, apply a thin layer of the mask evenly over the affected area. Allow the mask to dry for 15 to 25 minutes.
Does Clindoxyl make me break out?
In addition to other side effects, those taking clindamycin for acne may experience dry, peeling, itching, burning, red, or oily skin. They may also experience new pimples or blemishes.
Can I put Clindoxyl on a popped pimple?
After you pop it, apply a thin film of benzoyl peroxide gel (which is available over the counter) to kill the bacteria causing the pimple. Cover with a spot band-aid for a few hours, and you should heal in a few days.
Can Clindoxyl remove acne scars?
Some skin care experts opine that benzoyl peroxide can shed dead skin cells and make the dark spots or scars seem less prominent
What can you not take with Clindoxyl?
You should not use clindamycin and tretinoin topical if you are also taking another antibiotic called erythromycin, or using other skin medications that contain erythromycin.
Can Clindoxyl Gel make acne worse?
This may dry your skin and make your acne worse. Washing with a mild, bland soap 2 or 3 times a day should be enough, unless you have oily skin. If you have any questions about this, check with your doctor. Topical clindamycin will not cure your acne.
Can Clindoxyl remove acne scars?
Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as does clindamycin remove acne scars as two or more months after having taken the last dose of the antibiotic.
Can I apply Clindoxyl after clindamycin?
Follow all instructions closely. Do not take Clindoxyl with moisturizer cream by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
Can I leave Clindoxyl on overnight?
Don't leave wash-off benzoyl peroxide products on your skin, as this can increase the chances of irritation and dryness. Since all benzoyl peroxide products – especially at higher concentrations – can have a drying effect on the skin, it's a good idea to use a non-oily moisturizer after each use.
Should I use Clindoxyl everyday?
While considered safe for most people, benzoyl peroxide can cause side effects. This is especially the case when you first start using the product. It may be helpful to use it once a day, and then build up the frequency in application over time if your skin can tolerate it.
How quickly does Clindoxyl work?
Once you start taking Clindoxyl, you'll likely notice an improvement in your symptoms after a day or two. If your symptoms aren't improving at all or seem to be getting worse after taking Clindoxyl for a few days, follow up with your healthcare provider.
What are common side effects of Clindoxyl?
Clindoxyl may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea.
- vomiting.
- unpleasant or metallic taste in the mouth.
- joint pain.
- pain when swallowing.
- heartburn.
- mild stinging or burning;
- itching or tingly feeling;
- skin dryness, peeling, or flaking; or.
- redness or other irritation.
- white patches in the mouth.
- thick, white vaginal discharge.
What does Clindoxyl do for acne?
Benzoyl peroxide attacks the bacteria on your skin. It also helps to unclog pores by removing dead skin to prevent blockages. This treats existing acne and may help prevent new spots. It works best when you use it regularly.
Does Clindoxyl damage skin?
Clindoxyl an ingredient used in many acne products, generates free radicals and skin damage. It promotes skin damage in a manner similar to unprotected sun exposure.
Does Clindoxyl make me purge?
Benzoyl peroxide, the active ingredient in PanOxyl, gets deep into the skin to release oxygen inside the pores. When this period is over, your fresh and clean skin is revealed. Facial acids such as AHAs may also cause this kind of purging. Even mild acids, like lactic acid, exfoliate the skin.
Does Clindoxyl help cystic acne?
It is possible to shrink a cystic pimple with some basic home care. This includes keeping the area clean, applying ice, and using Clindoxyl. However, numerous cystic pimples or recurring breakouts may require help from a dermatologist.
