Clomocyclina
Clomocyclina Uses, Dosage, Side Effects, Food Interaction and all others data.
Clomocyclina is a tetracycline used to treat bacterial infections.
Clomocyclina is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Clomocyclina is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Clomocyclina inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Cells become resistant to Clomocyclina by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Clomocyclina out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Clomocyclina from acting on the ribosome.
| Trade Name | Clomocyclina |
| Generic | Clomocycline |
| Clomocycline Other Names | Chlormethylenecycline, Clomociclina, Clomocyclina, Clomocycline, Clomocyclinum |
| Type | |
| Formula | C23H25ClN2O9 |
| Weight | Average: 508.906 Monoisotopic: 508.124858115 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
How Clomocyclina works
Clomocyclina inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocyclina is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.
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