Clona Cure

Clona Cure Uses, Dosage, Side Effects, Food Interaction and all others data.

Clona Cure Cream is a multiple combination cream which exhibits anti-bacterial, anti-protozoal, anti-fungal and steroid properties to control inflammation. Ofloxacin is a broad-spectrum antibiotic that acts against many gram-positive and gram-negative bacteria. Ornidazole belongs

to the nitroimidazole group of antibiotics and is used to treat amoeba and trichomonas infections. Terbinafine is a topical antifungal and antiparasitic drug. Clobetasol is a potent corticosteroid which exhibits anti-inflammatory, anti-pruritic and vasoconstrictive properties.

Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Clobetasol propionate is generally applied twice daily so the duration of action is long. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.

Trade Name Clona Cure
Generic Clobetasol Propionate
Clobetasol Propionate Other Names clobetasol 17-propanoate, clobetasol 17-propionate, Clobetasol propionate, Clobetasol propionate E
Type Cream
Formula C25H32ClFO5
Weight Average: 466.97
Monoisotopic: 466.192230046
Protein binding

Data regarding the protein binding of clobetasol propionate are not readily available. Corticosteroids are generally bound to corticosteroid binding globulin and serum albumin in plasma.

Groups Approved
Therapeutic Class Clobetasol / Clobetasone & Combined Preparations
Manufacturer Cure N Cure Pharmaceuticals Pvt Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Clona Cure
Clona Cure

Uses

Clona Cure is used for:

  • Initial control of all forms of hyperacute eczema in all age groups
  • Chronic hyperkeratotic eczema of the hands and feet and patches of chronic lichen simplex
  • Chronic hyperkeratotic psoriasis of any area of the body
  • Severe acute photosensitivity
  • Hypertrophic lichen planus
  • Localized bullous disorders
  • Keloid scarring
  • Pretibial myxoedema
  • Vitiligo
  • Suppression of reaction after cryotherapy
  • Scalp Solution is used for the topical therapy of recalcitrant corticosteroid-responsive dermatoses of the scalp, including recalcitrant cases of psoriasis and seborrheic dermatitis.

Clona Cure is also used to associated treatment for these conditions: Alopecia, Severe Plaque psoriasis, Corticosteroid responsive, Inflammatory Dermatosis, Corticosteroid responsive, pruritic Dermatosis, Moderate Plaque psoriasis, Moderate Scalp Psoriasis, Severe Scalp Psoriasis

How Clona Cure works

The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.

Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.

Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.

Dosage

Clona Cure dosage

Nyclobate Cream & Ointment

Adults and children over 1 year:

• Apply sparingly to cover the affected area, and gently rub into the skin. Frequency of application is 2 to 3 times daily according to the severity of the condition. The total dose applied should not exceed 50 g weekly.

• Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient\\\'s condition being reviewed.

• Repeated short courses of Clobetasol may be used to control exacerbations

Children below 1 year: Under 1 year this preparation is not recommended

Nyclobate Scalp Application

• It should be applied to the affected scalp areas twice daily, once in morning and once at night.

• Total dosage should not exceed 50 ml per week.

• As with other highly active topical steroid preparations, therapy should be discontinued when control is achieved

Children: Under 1 year this preparation is not recommended.

Nyclobate Shampoo

• It should be applied to the dry (not wet) scalp once a day to the affected areas only.

• It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing.

• Treatment should be limited to 4 consecutive weeks.

• Total dosage of shampoo should not exceed 50 g per week.

• Under 18 years this preparation is not recommended.

Side Effects

Generally Clona Cure is well tolerated. However, few side effects after prolonged and intensive treatment may cause local atrophic changes in the skin such as Burning, itching, irritation, dry skin eczema.

Toxicity

Data regarding acute overdoses of glucocorticoids are rare. Overdoses of clobetasol propionate can lead to reversible HPA axis suppression and glucocorticoid insufficiency. Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency.[A188405] Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.[A188405]

Precaution

Do not swallow. For external use only.

Interaction

No hazardous interactions have been reported with use of Clona Cure.

Food Interaction

No interactions found.

Volume of Distribution

Data regarding the volume of distribution of clobetasole propionate are not readily available.

Elimination Route

Twice daily application of clobetasol foam leads to a Cmax of 59±36pg/mL with a Tmax of 5 hours. Clobetasol cream showed an increase in clobetasol concentrations from 50.7±96.0pg/mL to 56.3±104.7pg/mL.

Half Life

Data regarding the half life of clobetasol propionate are not readily available.

Clearance

Data regarding the clearance of clobetasol propionate are not readily available.

Elimination Route

Corticosteroids are eliminated predominantly in the urine.

Pregnancy & Breastfeeding use

The safe use of Clona Cure during pregnancy & lactation has not been established.

Contraindication

Contraindicated in Cutaneous infections such as impetigo, tinea corporis and herpes simplex, Infestations such as scabies, Acne vulgaris, Hypersensitivity, Rosacea, Gravitational ulceration, Perioral dermatitis, Children under 1 year

Special Warning

Use in Paediatrics: The drug may be used in paediatrics patients in appropriate dosage, but large quantities for prolonged period should be avoided. It is contraindicated in children less than one year.

Acute Overdose

Acute overdosage is very unlikely to occur. However, in the case of chronic overdose or misuse the features of hypercortisolism may appear.

Interaction with other Medicine

No hazardous interactions have been reported

Storage Condition

Do not store above 30 0 C. Keep away from light and out of the reach of children. Do not freeze.

Innovators Monograph

You find simplified version here Clona Cure

Clona Cure contains Clobetasol Propionate see full prescribing information from innovator Clona Cure Monograph, Clona Cure MSDS, Clona Cure FDA label

FAQ

What is clobetasol propionate used for?

Clobetasol propionate is a topical corticosteroid medication used to treat skin conditions such as psoriasis, eczema, and dermatitis.

How does clobetasol propionate work?

Clobetasol propionate works by reducing inflammation and suppressing the immune system response, which helps to alleviate symptoms such as itching, swelling, and redness.

How is clobetasol propionate applied?

Clobetasol propionate is typically applied to the affected area of skin once or twice daily, as directed by a healthcare provider. It is available as a cream, ointment, or foam.

What are the side effects of clobetasol propionate?

Common side effects of clobetasol propionate include skin thinning, stinging, burning, and itching. Long-term use can also lead to skin discoloration and increased risk of infection.

Can clobetasol propionate be used on the face?

Clobetasol propionate should not be used on the face, as this area is more sensitive to the medication and is more prone to developing skin thinning and other adverse effects.

Can clobetasol propionate be used during pregnancy?

Clobetasol propionate should only be used during pregnancy if the potential benefits outweigh the potential risks to the fetus. Women who are pregnant or planning to become pregnant should discuss the risks and benefits of using this medication with their healthcare provider.

Can clobetasol propionate be used in children?

Clobetasol propionate should be used with caution in children, as they may be more sensitive to the medication and more prone to developing side effects. Children should only use this medication under the supervision of a healthcare provider.

How long can clobetasol propionate be used for?

The duration of treatment with clobetasol propionate will vary depending on the severity of the condition and the individual's response to treatment. It is important to use this medication only as directed by a healthcare provider and to follow proper application techniques to minimize the risk of side effects.

*** Taking medicines without doctor's advice can cause long-term problems.
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