Clopidogrel Sarb
Clopidogrel Sarb Uses, Dosage, Side Effects, Food Interaction and all others data.
(Clopidogrel Sarb) is an inhibitor of platelet aggregation. Lopirel (Clopidogrel Sarb) selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Clopidogrel Sarb is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. It has a long duration of action as it is taken once daily and a large therapeutic window as it is given in doses of 75-300mg daily.
| Trade Name | Clopidogrel Sarb |
| Availability | Prescription only |
| Generic | Clopidogrel |
| Clopidogrel Other Names | Clopidogrel, Clopidogrelum |
| Related Drugs | aspirin, lisinopril, metoprolol, propranolol, Xarelto, Plavix, Brilinta, enoxaparin, rivaroxaban, pravastatin |
| Type | |
| Formula | C16H16ClNO2S |
| Weight | Average: 321.822 Monoisotopic: 321.059027158 |
| Protein binding | Both the active and inactive metabolites of clopidogrel are 98% protein bound in plasma. Studies in cows show clopidogrel 71-85.5% bound to serum albumin. |
| Groups | Approved |
| Therapeutic Class | Anti-platelet drugs |
| Manufacturer | |
| Available Country | Portugal |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(Clopidogrel Sarb) is used for the reduction of atherosclerotic events (myocardial infarction, ischaemic stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Clopidogrel Sarb is also used to associated treatment for these conditions: Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Cardiovascular Events, Atherothrombotic events
How Clopidogrel Sarb works
Clopidogrel Sarb is metabolized to its active form by carboxylesterase-1. The active form is a platelet inhibitor that irreversibly binds to P2Y12 ADP receptors on platelets. This binding prevents ADP binding to P2Y12 receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet aggregation.
Dosage
Clopidogrel Sarb dosage
The recommended dose of Lopirel (Clopidogrel Sarb) is 75 mg once daily with or without food.
Side Effects
Generally Clopidogrel Sarb is well tolerated. However, a few common side effects i.e. Influenza-like symptoms, headache, upper respiratory tract infection, dizziness, muscle and back pain, and rash may occur.
Toxicity
A single dose of clopidogrel at 1500-2000mg/kg was lethal to mice and rats while 3000mg/kg was lethal to baboons. Symptoms of overdose include vomiting, breathing difficulty, gastrointestinal hemorrhage, and prostration. Clopidogrel Sarb is irreversibly bound to platelets for their lifetime, which is approximately 11 days. Overdoses of clopidogrel can be treated with platelet transfusions to restore clotting ability.
Precaution
As with other anti-platelet agents, Clopidogrel Sarb should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. Clopidogrel Sarb should be discontinued 7 days prior to surgery. Clopidogrel Sarb should be used with caution in hepatically impaired patients who may have bleeding diatheses.
Interaction
Concomitant use of Heparin, Warfarin and NSAIDs with Clopidogrel Sarb should be undertaken with caution. Clopidogrel Sarb potentiate the effect of Aspirin on collagen-induced platelet aggregation. The safety of chronic concomitant administration of Aspirin and Clopidogrel Sarb has not been established.
Food Interaction
- Take with or without food.
Clopidogrel Sarb Drug Interaction
Moderate: aspirin, aspirin, aspirin, aspirin, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: ubiquinone, ubiquinone, rosuvastatin, rosuvastatin, metoprolol, metoprolol, metoprolol, metoprolol, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Clopidogrel Sarb Disease Interaction
Major: bleedingModerate: liver diseaseMinor: renal dysfunction
Volume of Distribution
The apparent volume of distribution of clopidogrel is 39,240±33,520L.
Elimination Route
A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. Clopidogrel Sarb can be taken with or without food. A meal decreases the AUC of the active metabolite by 57%. The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. Clopidogrel Sarb reached a Cmax of 2.04±2.0ng/mL in 1.40±1.07h.
The AUC for a 300mg oral dose of clopidogrel was 45.1±16.2ng*h/mL for poor metabolizers, 65.6±19.1ng*h/mL for intermediate metabolizers, and 104.3±57.3ng*h/mL for extensive metabolizers. The Cmax was 31.3±13ng/mL for poor metabolizers, 43.9±14ng/mL for intermediate metabolizers, and 60.8±34.3ng/mL for extensive metabolizers.
Half Life
That half life of clopidogrel is approximately 6 hours following a 75mg oral dose while the half life of the active metabolite is approximately 30 minutes.
Clearance
The clearance of a 75mg oral dose was 18,960±15,890L/h and for a 300mg oral dose was 16,980±10,410L/h.
Elimination Route
An oral dose of radiolabelled clopidogrel is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of clopidogrel is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies of Clopidogrel Sarb in pregnant women. However, Clopidogrel Sarb should be used during pregnancy only if clearly needed.
Lactation: Clopidogrel Sarb is not recommended for use while breast-feeding. It is not known for sure whether Clopidogrel Sarb is excreted in breast milk, although it is suspected that it is.
Contraindication
Clopidogrel Sarb is contraindicated in patients with a hypersensitivity to the drug substance or any component of the product, and those with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Special Warning
Use in children: Safety and effectiveness of Clopidogrel Sarb in pediatric population have not been established.
Acute Overdose
In the event of over dosage no adverse effects were reported and no therapy was substituted.
Symptoms: Prolonged bleeding time and subsequent bleeding complications.
Management: May restore clotting ability with platelet transfusion.
Storage Condition
Store at 25° C.
Innovators Monograph
You find simplified version here Clopidogrel Sarb
Clopidogrel Sarb contains Clopidogrel see full prescribing information from innovator Clopidogrel Sarb Monograph, Clopidogrel Sarb MSDS, Clopidogrel Sarb FDA label
FAQ
What is Clopidogrel Sarb used for?
Clopidogrel Sarb is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent. It prevents platelets from sticking together and forming a dangerous blood clot. Taking Clopidogrel Sarb helps prevent blood clots if you have an increased risk of having them.
How safe is Clopidogrel Sarb?
Clopidogrel Sarb is generally safe to take for a long time. In fact, it works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to help protect your stomach while you're taking Clopidogrel Sarb.
how does Clopidogrel Sarb work?
Clopidogrel Sarb slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot.
What are the common side effects of Clopidogrel Sarb?
Common side effects of Clopidogrel Sarb are include:
- excessive tiredness.
- headache.
- dizziness.
- nausea.
- vomiting.
- stomach pain.
- diarrhea.
- nosebleed.
Is Clopidogrel Sarb safe during pregnancy?
Clopidogrel Sarb can be used throughout pregnancy. There may be another issue related to delivery, however. The patient in question is planning to have a repeat cesarean, and there is some evidence that Clopidogrel Sarb may cause more hemorrhagic complications of surgery.
Is Clopidogrel Sarb safe during breastfeeding?
The manufacturer reports that no adverse effects have been observed in breastfed infants with maternal Clopidogrel Sarb use during lactation in a small number of postmarketing cases.
Can I drink alcohol with Clopidogrel Sarb?
You can drink alcohol with Clopidogrel Sarb. But do not drink too much while taking this medicine.
When should be taken of Clopidogrel Sarb?
It is usually taken once a day with or without food. Take Clopidogrel Sarb at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Can I take Clopidogrel Sarb on an empty stomach?
You can be taken with or without food.
How long does Clopidogrel Sarb take to work?
Clopidogrel Sarb works within 2 hours of taking it.
How is Clopidogrel Sarb eliminated from the body?
An oral dose of radiolabelled Clopidogrel Sarb is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of Clopidogrel Sarb is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Is it safe to take Clopidogrel Sarb every other day?
Long term dual anti-platelet therapy with aspirin 81 mg daily and Clopidogrel Sarb 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.
What is Clopidogrel Sarb half-life?
Oral dose of 75 mg, Clopidogrel Sarb has a half-life of approximately 6 hours.
Can I take Clopidogrel Sarb for a long time?
Clopidogrel Sarb oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you stop taking the drug or don't take it at all: You increase your risk of heart attack or stroke. These conditions can be fatal.
Who should not take Clopidogrel Sarb?
You should not use Clopidogrel Sarb if you have any active bleeding such as a stomach ulcer or bleeding in the brain.Clopidogrel Sarb increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
What happens if I miss a dose?
Take Clopidogrel Sarb as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention.Overdose can cause excessive bleeding.
Can Clopidogrel Sarb cause heart attacks?
Clopidogrel Sarb may be at increased risk of serious problems like heart attacks or strokes.
Does Clopidogrel Sarb affect the kidneys?
In summary, among patients hospitalized with ACS and treated with Clopidogrel Sarb, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.
Does Clopidogrel Sarb affect sleep?
Clopidogrel Sarb are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.
Does Clopidogrel Sarb affect the liver?
Liver damage is a rare side effect of Clopidogrel Sarb.
Does Clopidogrel Sarb weaken immune system?
Clopidogrel Sarb may also cause weak immunosuppression that might contribute to risk of fatal infections.
