Clopidogrel Wynnova
Clopidogrel Wynnova Uses, Dosage, Side Effects, Food Interaction and all others data.
(Clopidogrel Wynnova) is an inhibitor of platelet aggregation. Lopirel (Clopidogrel Wynnova) selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Clopidogrel Wynnova is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. It has a long duration of action as it is taken once daily and a large therapeutic window as it is given in doses of 75-300mg daily.
| Trade Name | Clopidogrel Wynnova |
| Availability | Prescription only |
| Generic | Clopidogrel |
| Clopidogrel Other Names | Clopidogrel, Clopidogrelum |
| Related Drugs | aspirin, lisinopril, metoprolol, propranolol, Xarelto, Plavix, Brilinta, enoxaparin, rivaroxaban, pravastatin |
| Type | |
| Formula | C16H16ClNO2S |
| Weight | Average: 321.822 Monoisotopic: 321.059027158 |
| Protein binding | Both the active and inactive metabolites of clopidogrel are 98% protein bound in plasma. Studies in cows show clopidogrel 71-85.5% bound to serum albumin. |
| Groups | Approved |
| Therapeutic Class | Anti-platelet drugs |
| Manufacturer | |
| Available Country | Portugal |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
(Clopidogrel Wynnova) is used for the reduction of atherosclerotic events (myocardial infarction, ischaemic stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Clopidogrel Wynnova is also used to associated treatment for these conditions: Acute Coronary Syndrome (ACS), Acute Myocardial Infarction (AMI), Cardiovascular Events, Atherothrombotic events
How Clopidogrel Wynnova works
Clopidogrel Wynnova is metabolized to its active form by carboxylesterase-1. The active form is a platelet inhibitor that irreversibly binds to P2Y12 ADP receptors on platelets. This binding prevents ADP binding to P2Y12 receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet aggregation.
Dosage
Clopidogrel Wynnova dosage
The recommended dose of Lopirel (Clopidogrel Wynnova) is 75 mg once daily with or without food.
Side Effects
Generally Clopidogrel Wynnova is well tolerated. However, a few common side effects i.e. Influenza-like symptoms, headache, upper respiratory tract infection, dizziness, muscle and back pain, and rash may occur.
Toxicity
A single dose of clopidogrel at 1500-2000mg/kg was lethal to mice and rats while 3000mg/kg was lethal to baboons. Symptoms of overdose include vomiting, breathing difficulty, gastrointestinal hemorrhage, and prostration. Clopidogrel Wynnova is irreversibly bound to platelets for their lifetime, which is approximately 11 days. Overdoses of clopidogrel can be treated with platelet transfusions to restore clotting ability.
Precaution
As with other anti-platelet agents, Clopidogrel Wynnova should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. Clopidogrel Wynnova should be discontinued 7 days prior to surgery. Clopidogrel Wynnova should be used with caution in hepatically impaired patients who may have bleeding diatheses.
Interaction
Concomitant use of Heparin, Warfarin and NSAIDs with Clopidogrel Wynnova should be undertaken with caution. Clopidogrel Wynnova potentiate the effect of Aspirin on collagen-induced platelet aggregation. The safety of chronic concomitant administration of Aspirin and Clopidogrel Wynnova has not been established.
Food Interaction
- Take with or without food.
Clopidogrel Wynnova Drug Interaction
Moderate: aspirin, aspirin, aspirin, aspirin, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: ubiquinone, ubiquinone, rosuvastatin, rosuvastatin, metoprolol, metoprolol, metoprolol, metoprolol, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Clopidogrel Wynnova Disease Interaction
Major: bleedingModerate: liver diseaseMinor: renal dysfunction
Volume of Distribution
The apparent volume of distribution of clopidogrel is 39,240±33,520L.
Elimination Route
A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. Clopidogrel Wynnova can be taken with or without food. A meal decreases the AUC of the active metabolite by 57%. The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. Clopidogrel Wynnova reached a Cmax of 2.04±2.0ng/mL in 1.40±1.07h.
The AUC for a 300mg oral dose of clopidogrel was 45.1±16.2ng*h/mL for poor metabolizers, 65.6±19.1ng*h/mL for intermediate metabolizers, and 104.3±57.3ng*h/mL for extensive metabolizers. The Cmax was 31.3±13ng/mL for poor metabolizers, 43.9±14ng/mL for intermediate metabolizers, and 60.8±34.3ng/mL for extensive metabolizers.
Half Life
That half life of clopidogrel is approximately 6 hours following a 75mg oral dose while the half life of the active metabolite is approximately 30 minutes.
Clearance
The clearance of a 75mg oral dose was 18,960±15,890L/h and for a 300mg oral dose was 16,980±10,410L/h.
Elimination Route
An oral dose of radiolabelled clopidogrel is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of clopidogrel is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies of Clopidogrel Wynnova in pregnant women. However, Clopidogrel Wynnova should be used during pregnancy only if clearly needed.
Lactation: Clopidogrel Wynnova is not recommended for use while breast-feeding. It is not known for sure whether Clopidogrel Wynnova is excreted in breast milk, although it is suspected that it is.
Contraindication
Clopidogrel Wynnova is contraindicated in patients with a hypersensitivity to the drug substance or any component of the product, and those with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Special Warning
Use in children: Safety and effectiveness of Clopidogrel Wynnova in pediatric population have not been established.
Acute Overdose
In the event of over dosage no adverse effects were reported and no therapy was substituted.
Symptoms: Prolonged bleeding time and subsequent bleeding complications.
Management: May restore clotting ability with platelet transfusion.
Storage Condition
Store at 25° C.
Innovators Monograph
You find simplified version here Clopidogrel Wynnova
Clopidogrel Wynnova contains Clopidogrel see full prescribing information from innovator Clopidogrel Wynnova Monograph, Clopidogrel Wynnova MSDS, Clopidogrel Wynnova FDA label
FAQ
What is Clopidogrel Wynnova used for?
Clopidogrel Wynnova is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent. It prevents platelets from sticking together and forming a dangerous blood clot. Taking Clopidogrel Wynnova helps prevent blood clots if you have an increased risk of having them.
How safe is Clopidogrel Wynnova?
Clopidogrel Wynnova is generally safe to take for a long time. In fact, it works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to help protect your stomach while you're taking Clopidogrel Wynnova.
how does Clopidogrel Wynnova work?
Clopidogrel Wynnova slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot.
What are the common side effects of Clopidogrel Wynnova?
Common side effects of Clopidogrel Wynnova are include:
- excessive tiredness.
- headache.
- dizziness.
- nausea.
- vomiting.
- stomach pain.
- diarrhea.
- nosebleed.
Is Clopidogrel Wynnova safe during pregnancy?
Clopidogrel Wynnova can be used throughout pregnancy. There may be another issue related to delivery, however. The patient in question is planning to have a repeat cesarean, and there is some evidence that Clopidogrel Wynnova may cause more hemorrhagic complications of surgery.
Is Clopidogrel Wynnova safe during breastfeeding?
The manufacturer reports that no adverse effects have been observed in breastfed infants with maternal Clopidogrel Wynnova use during lactation in a small number of postmarketing cases.
Can I drink alcohol with Clopidogrel Wynnova?
You can drink alcohol with Clopidogrel Wynnova. But do not drink too much while taking this medicine.
When should be taken of Clopidogrel Wynnova?
It is usually taken once a day with or without food. Take Clopidogrel Wynnova at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Can I take Clopidogrel Wynnova on an empty stomach?
You can be taken with or without food.
How long does Clopidogrel Wynnova take to work?
Clopidogrel Wynnova works within 2 hours of taking it.
How is Clopidogrel Wynnova eliminated from the body?
An oral dose of radiolabelled Clopidogrel Wynnova is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of Clopidogrel Wynnova is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.
Is it safe to take Clopidogrel Wynnova every other day?
Long term dual anti-platelet therapy with aspirin 81 mg daily and Clopidogrel Wynnova 75 mg every other day beyond 12 months after PCI with DES may be a safe and efficacious cost-saving strategy to prevent VLST.
What is Clopidogrel Wynnova half-life?
Oral dose of 75 mg, Clopidogrel Wynnova has a half-life of approximately 6 hours.
Can I take Clopidogrel Wynnova for a long time?
Clopidogrel Wynnova oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you stop taking the drug or don't take it at all: You increase your risk of heart attack or stroke. These conditions can be fatal.
Who should not take Clopidogrel Wynnova?
You should not use Clopidogrel Wynnova if you have any active bleeding such as a stomach ulcer or bleeding in the brain.Clopidogrel Wynnova increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
What happens if I miss a dose?
Take Clopidogrel Wynnova as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention.Overdose can cause excessive bleeding.
Can Clopidogrel Wynnova cause heart attacks?
Clopidogrel Wynnova may be at increased risk of serious problems like heart attacks or strokes.
Does Clopidogrel Wynnova affect the kidneys?
In summary, among patients hospitalized with ACS and treated with Clopidogrel Wynnova, lower levels of kidney function were associated with a greater risk of death, hospitalization for AMI, and major bleeding.
Does Clopidogrel Wynnova affect sleep?
Clopidogrel Wynnova are among the most prescribed drugs in cardiology and are not cited as causing insomnia or sleepiness.
Does Clopidogrel Wynnova affect the liver?
Liver damage is a rare side effect of Clopidogrel Wynnova.
Does Clopidogrel Wynnova weaken immune system?
Clopidogrel Wynnova may also cause weak immunosuppression that might contribute to risk of fatal infections.
