Clorchinaldol Arena
Clorchinaldol Arena Uses, Dosage, Side Effects, Food Interaction and all others data.
Clorchinaldol Arena was used historically as a topical antiseptic under the trade name Sterosan. It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Clorchinaldol Arena is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment of bacterial vaginosis.
Clorchinaldol Arena is bacteriocidal in both gram positive and gram negative bacteria. It is more effective in targeting gram positive bacteria, particularly staphylococci.
| Trade Name | Clorchinaldol Arena |
| Generic | Chlorquinaldol |
| Chlorquinaldol Other Names | Chlorchinaldol, Chlorquinaldol, Chlorquinaldolum, Clorquinaldol |
| Type | |
| Formula | C10H7Cl2NO |
| Weight | Average: 228.07 Monoisotopic: 226.9904692 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Romania |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Clorchinaldol Arena was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment of vaginal infections.
Clorchinaldol Arena is also used to associated treatment for these conditions: Allergic Skin Reaction, Dermatitis, Skin Infections, Vaginal atrophy with infection, Allergic skin manifestations, Mycotic skin infection
How Clorchinaldol Arena works
The mechanism by which Clorchinaldol Arena exerts it's bacteriocidal effect is unknown. 8-hydroxyquinolines are known to be bidentate chelators of several metal ions which act as critical enzyme cofactors. However, the addition of exogenous metal ions does not appear to alter the minimum inhibitory concentration for mycobacterium tuberculosis suggesting that the primary mechanism does not rely on chelation.
Toxicity
Oral LD50 (rat) - 660mg/kg
Food Interaction
No interactions found.Elimination Route
There is a high degree of variability in the extent of absorption of topically applied chorquinaldol preparations. It is reported to be between 4.2 and 23.5% of the applied dose. This is quite low compared to orally administered preparations which displayed 67.6% absorption in the same study.
Elimination Route
Chlorquinadol is primarily excreted in the urine as the sulfate form. About 2% is excreted as the parent drug.
Innovators Monograph
You find simplified version here Clorchinaldol Arena
