Closerin

Closerin Uses, Dosage, Side Effects, Food Interaction and all others data.

Antibiotic substance produced by Streptomyces garyphalus.

Closerin, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Closerin works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria

Closerin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Closerin
Availability	Prescription only
Generic	Cycloserine
Cycloserine Other Names	alpha-Cycloserine, Cicloserina, cyclo-D-Serine, Cycloserine, Cyclosérine, Cycloserinum, D-Cycloserine, Orientomycin
Related Drugs	prednisone, ciprofloxacin, levofloxacin, Levaquin, rifampin, Deltasone, Sterapred, Prednicot
Weight	250mg
Type	Capsule
Formula	C₃H₆N₂O₂
Weight	Average: 102.0919 Monoisotopic: 102.042927446
Groups	Approved
Therapeutic Class
Manufacturer	Century Pharmaceuticals (pvt) Ltd,
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Closerin is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).

Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).

Closerin is also used to associated treatment for these conditions: Refractory Tuberculosis, Refractory Urinary Tract Infection

How Closerin works

Closerin is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.

Toxicity

Oral LD₅₀ in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.

Food Interaction

Do not take with or immediately after a high-fat meal. High-fat meals may reduce the rate of absorption; however, the impact on the extent of absorption is unknown.

[Major] GENERALLY AVOID: Coadministration with alcohol may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone.

These effects may include dizziness, drowsiness, depression, anxiety, psychoses, memory impairment, confusion, and convulsions.

MANAGEMENT: Patients should be advised to avoid the consumption of alcohol during treatment with cycloserine or terizidone.

The use of these medications is contraindicated in patients with chronic alcohol consumption or alcoholism.

MONITOR CLOSELY: Coadministration with caffeine may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone.

These effects may include insomnia, excitability, irritability, anxiety, tremor, psychoses, and convulsions.

MANAGEMENT: Caution is advised when cycloserine or terizidone is used with caffeine.

Consumption of certain beverages or stimulants with very high caffeine levels should be avoided as a precautionary measure.