Clothixen

Clothixen Uses, Dosage, Side Effects, Food Interaction and all others data.

Clothixen is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Clothixen exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

Clothixen is a typical antipsychotic drug of the thioxanthine class. It has a low antipsychotic potency (half to 2/3 of chlorpromazine). Clothixen has not thoroughly demonstrated an antidepressant or analgesic effect but it has demonstrated antiemetic effects. It is used in the treatment of nervous, mental, and emotional conditions. Improvement in such conditions is thought to result from the effect of the medicine on nerve pathways in specific areas of the brain. Clothixen has a similar side effect profile to chlorpromazine, though allergic side effects and liver damage are less frequent.

Trade Name Clothixen
Generic Chlorprothixene
Chlorprothixene Other Names Chlorprothixen, Chlorprothixene, Chlorprothixine, Chlorprotixen, Chlorprotixene, Chlorprotixine, Chlothixen
Type
Formula C18H18ClNS
Weight Average: 315.86
Monoisotopic: 315.0848485
Groups Approved, Experimental, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Clothixen
Clothixen

Uses

Clothixen is a thioxanthene antipsychotic.

For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders.

Clothixen is also used to associated treatment for these conditions: Psychosis, Schizophrenia

How Clothixen works

Clothixen blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Toxicity

Symptoms of overdose include difficulty in breathing (severe), dizziness (severe), drowsiness (severe), muscle trembling, jerking, stiffness, or uncontrolled movements (severe), small pupils, unusual excitement, and unusual tiredness or weakness (severe).

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Elimination Route

Incomplete bioavailability.

Half Life

8 to 12 hours

Innovators Monograph

You find simplified version here Clothixen

*** Taking medicines without doctor's advice can cause long-term problems.
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