Coagulation Factor VIII
Coagulation Factor VIII Uses, Dosage, Side Effects, Food Interaction and all others data.
Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
Antihemophilic Factor binds factor IXa along with calcium and phospholipid, This complex converts factor X to factor Xa to facilitate clotting cascade.
Trade Name | Coagulation Factor VIII |
Generic | Antihemophilic factor, human recombinant |
Antihemophilic factor, human recombinant Other Names | Antihemophilic factor (recombinant), Antihemophilic factor recombinant, Antihemophilic factor, human recombinant, Antihemophilic factor, recombinant, Coagulation factor VIII, recombinant, Factor VIII (rDNA), Factor VIII (Recombinant), Factor VIII recombin, Factor VIII, recombinant, Human Factor VIII (Recombinant), Human factor VIII recombinant, Octocog alfa, rAHF, Recombinant antihemophilic factor VIII |
Type | |
Formula | C11794H18314N3220O3553S83 |
Weight | 264725.5 Da |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Coagulation Factor VIII is a form of recombinant coagulation Factor VIII used to treat hemophilia A, von Willebrand disease, and Factor XIII deficiency.
For the treatment of hemophilia A, von Willebrand disease and Factor XIII deficiency.
Coagulation Factor VIII is also used to associated treatment for these conditions: Bleeding, Hemophilia A, Perioperative Blood Loss, Bleeding in invasive procedures, Perioperative procedures
How Coagulation Factor VIII works
Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).
Food Interaction
No interactions found.Half Life
8.4-19.3 hrs
Clearance
- 4.1 mL/h•kg [Previously treated pediatric patients]
Innovators Monograph
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