Coal Tar + Precipitated Sulphur + Salicylic Acid

Coal Tar + Precipitated Sulphur + Salicylic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.

Coal Tar has antipruritic, keratoplastic and keratolytic properties. It slows down excessive epidermal cell turnover and is often used topically either alone or in combination with other drugs (e.g. salicyclic acid, sulfur) in conditions such as dandruff, seborrheic dermatitis or psoriasis.

Precipitated Sulpher is converted to hydrogen sulfide (H2S) through reduction, partly by bacteria. H2S kills bacteria (possibly including Propionibacterium acnes which plays a role in acne) fungi, and parasites such as scabies mites.

Salicylic Acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.

Coal Tar + Precipitated Sulphur + Salicylic Acid
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Coal Tar + Precipitated Sulphur + Salicylic Acid
Generic	Coal Tar + Precipitated Sulphur + Salicylic Acid
Type
Therapeutic Class	Coal-tar preparations
Manufacturer
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Coal Tar + Precipitated Sulphur + Salicylic Acid

Uses

This Scalp Ointment has mild, antipruritic, antiseptic and keratolytic properties. It is used for the treatment of common scaly skin disorders of the scalp such as psoriasis, eczema, seborrhoeic dermatitis and dandruff.

Coal Tar + Precipitated Sulphur + Salicylic Acid is also used to associated treatment for these conditions: Dandruff, Psoriasis, Seborrheic Dermatitis, Seborrhoeic Dermatitis of the ScalpAcne, Actinic Keratosis (AK), Alopecia Areata (AA), Atopic Dermatitis (AD), Blackheads, Chronic Eczema, Chronic cutaneous lupus erythematosus, Corns, Dandruff, Dermatitis, Contact, Dermatitis, Eczematous, Dermatitis, Eczematous of the scalp, Discoid Lupus Erythematosus (DLE), Foot Callus, Fungal skin infection, Furuncle, Hand Eczema, Hyperkeratosis, Hyperkeratosis follicularis et parafollicularis, Infections, Fungal, Infections, Fungal of the Skin Folds, Infections, Fungal of the face, Infections, Fungal of the feet, Infections, Fungal of the hand, Keratosis Palmaris et Plantaris, Lichen, Lichen Plano-Pilaris, Lichen Planus (LP), Lichen simplex chronicus, Molluscum Contagiosum, Musculoskeletal Pain, Neurodermatitis, Palmo-Plantar Pustulosis, Plantar Warts, Pruritus, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriasis of the scalp, Rash, Ringworm of the Skin, Ringworm of the scalp, Seborrheic Dermatitis, Seborrhoeic Dermatitis of the Scalp, Skin Infections, Bacterial, Verrucous Psoriasis, Warts, Calluses, Corticosteroid-responsive dermatoses, Keratinization disorders, Scaling, Scaling of skin, Scalp seborrhea, Superficial Fungal skin infection, Keratolysis

How Coal Tar + Precipitated Sulphur + Salicylic Acid works

Coal tar ointment is a keratolytic. It works by slowing bacterial growth and loosening and softening scales and crust.

Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.

Dosage

Coal Tar + Precipitated Sulphur + Salicylic Acid dosage

Adults, children over 12 years and the elderly: Apply to the affected areas of the scalp andremove after one hour using warm water and shampoo. Repeat the process daily for three toseven days until control has been obtained. With mild scaliness use intermittently as necessary.

Children 6–12 years: To be used under medical supervision only.

Children under 6 years:Notrecommended.

Coal Tar ointment is for external use only, ie applied onto the skin. Follow your doctor’s instructions and check the leaflet on how to use. In severe scaly scalp conditions it is usually necessary to apply Coal Tar ointment daily for 3-7 days until control has been obtained. With mild scaliness use intermittently as necessary, eg once a week.

Pierce the tube membrane by inverting the cap. This scalp applicator to the threaded portion of the tube.
Part the hair and apply a thin ribbon of Coal Tar ointment to the affected areas of the scalp. Take care to avoid contact with the eyes. Gently rub in the ointment and leave in contact with scalp for approximately one hour. Wash the hands immediately afterwards.
After One hour remove the ointment by showering or rinsing with warm water. If after the first week there is no improvement or after 4 weeks symptoms persist, consult your doctor. If you accidentally get some into your eyes wash it out immediately with plenty of cold tap water. If irritation of the eyes develops consult your doctor or pharmacist.

Side Effects

Coal Ta ointment may occasionally cause irritation of the skin, inflammation of the hair follicles and rarely photosensitivity of the skin.

Toxicity

LD50: Not available.

Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.

Precaution

For external use only. Avoid contact with eyes and other mucous membranes.

Interaction

Do not use other topical preparations on the treated area unless otherwise directed by your healthcare provider. They may interfere with treatment or increase skin irritation.