Cobaforte

Cobaforte Uses, Dosage, Side Effects, Food Interaction and all others data.

Benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Cobaforte
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Cobaforte
Generic	Mecobalamin + Benzyl Alcohol
Weight	500mcg
Type	Injection
Therapeutic Class
Manufacturer	Emcure Pharmaceuticals Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Benzyl alcohol lotion is used for the topical treatment of head lice infestation in patients 6 months of age and older. Benzyl alcohol Lotion does not have ovicidal activity.

Mecobalamin is used for-

Peripheral Neuropathies
Diabetic Neuropathy
Verteberal Syndrome
Nerve Compression Syndrome
Multiple sclerosis
Amyotrophic lateral sclerosis
Parkinson’s disease
Alzheimer’s disease
Diabetic retinopathy
Entrapment neuropathy
Drug induced neuropathy
Megaloblastic anemia due to Vitamin B12 deficiency

Cobaforte is also used to associated treatment for these conditions: Cold Sore, Fever blister, Head Lice Infestation, Insect Bites, Orofacial Pain, Skin Irritation, Sunburn, Abrasions, Minor burns, Superficial WoundsVitamin B12 Deficiency, Nutritional supplementation

How Cobaforte works

Benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.

Dosage

Cobaforte dosage

Adult:Apply lotion to dry hair, using enough to completely saturate hair & scalp, rinse off with water after 10 minutes. Repeat treatment in 7 days.

Amount of Lotion Needed to Cover Scalp and Hair Completely

Hair length 0-2 inches: 4-6 ounces
Hair length 2-4 inches: 6-8 ounces
Hair length 4-8 inches: 8-12 ounces
Hair length 8-16 inches: 12-24 ounces
Hair length 16-22 inches: 24-32 ounces
Hair length >22 inches: 32-48 ounces

Child:

<6 months: Do not use
>6 months: Apply lotion to dry hair, using enough to completely saturate hair & scalp, rinse off with water after 10 minutes; repeat treatment in 7 days

Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.

Injection:

Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy

Side Effects

Generally well tolerated. However, a few allergic reactions may be seen. Irritation, itching, redness, tingling, or numbness at the application site may occur. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.

Toxicity

1250 mg/kg (rat, oral) LD50 400 mg/kg IPR-RAT LD50 2000 mg/kg SKN-RBT LD50 53 mg/kg IVN-RAT LD50 2500 mg/kg ORL-GPG LD50

Precaution

Constant or forceful scratching of the skin/scalp may lead to a bacterial skin infection.

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Interaction

No formal drug interaction studies to date.

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Pregnancy & Breastfeeding use

Pregnancy Category B. Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Lactation: Excretion in milk unknown; use with caution

Not recommended during pregnancy & lactation.