Cocaine Hydrochloride

Cocaine Hydrochloride Uses, Dosage, Side Effects, Food Interaction and all others data.

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine Hydrochloride, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Cocaine Hydrochloride is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.

Trade Name Cocaine Hydrochloride
Generic Cocaine
Cocaine Other Names Benzoylmethylecgonine, beta-Cocain, Cocain, Cocaina, Cocaine, Cocainum, Kokain, L-Cocain, L-Cocaine, Methyl benzoylecgonine, Neurocaine
Type Nasal
Formula C17H21NO4
Weight Average: 303.3529
Monoisotopic: 303.147058165
Groups Approved, Illicit
Therapeutic Class
Manufacturer Martindale Pharma, an Ethypharm Group Company
Available Country United Kingdom, United States
Last Updated: September 19, 2023 at 7:00 am
Cocaine Hydrochloride
Cocaine Hydrochloride

Uses

Cocaine Hydrochloride is an ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities.

For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.

How Cocaine Hydrochloride works

Cocaine Hydrochloride produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. Cocaine Hydrochloride is the only local anesthetic with vasoconstrictive properties. This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system. Cocaine Hydrochloride binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. Its effect on dopamine levels is most responsible for the addictive property of cocaine.

Toxicity

Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg

Food Interaction

No interactions found.

Elimination Route

Cocaine Hydrochloride is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.

Half Life

1 hour

Innovators Monograph

You find simplified version here Cocaine Hydrochloride

*** Taking medicines without doctor's advice can cause long-term problems.
Share