Combipen
Combipen Uses, Dosage, Side Effects, Food Interaction and all others data.
Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other lactamases.
Interferes with cell wall mucopeptide synthesis during active multiplication, resulting in bactericidal activity against susceptible microorganisms.
| Trade Name | Combipen |
| Generic | Procaine Penicillin + Benzyl Penicillin |
| Weight | (3lac unit+1 lac unit)/vial, |
| Type | Injection, Capsule |
| Therapeutic Class | Benzylpenicillin & Phenoxymethyl penicillin |
| Manufacturer | Acme Laboratories Limited, Strides Shasun Limited |
| Available Country | Bangladesh, India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
It is used for the treatment or prevention of any infection caused by Penicillin sensitive bacteria where a long acting Penicillin is required. It is used for-
- Gonorrhoea caused by Penicillin sensitive microorganisns
- Prevention of endocarditis during dental procedures
- Gas-gangrene following amputation
This is used for the treatment of gonorrhoea, syphilis and other conditions caused by penicillin-sensitive organisms where a long acting compound is required. Procaine Penicillin kills bacteria by interfering in the synthesis of the bacterial cell wall. It is active against most Gram-positive bacteria and a few Gram-negative species, notably Neisseria meningitidis and Neisseria gonnorhoeae. It is active against spirochaetes such as Treponema pallidum.
Dosage
Combipen dosage
Add 3 ml of water for injection and shake vigorously.
Adults: 4,00,000 units once daily or twice daily.
Children: Over 25 kg as for adults; under 25 kg reduce proportionally. In severe cases dose may be doubled.
Intramuscular injection is the only route of administration of Procaine Penicillin.
This should be injected IM into the buttocks, thigh, deltoid or triceps muscle. In case continuous injection is necessitated, the injection site should be changed every time.
Add about 8 ml of sterile water for injection to the vial and shake vigorously to make a homogenous suspended solution.
Side Effects
Allergic reactions may occur but usually resolve on cessation of therapy.
Precaution
Hypersensitivity to cephalosporins. Renal impairment. CHF. Infant. Elderly.
Interaction
Potentially hazardous interactions: invitro Penicillin inactivates Amino- glycosides, so that they should not be mixed in infusion fluids.
Pregnancy & Breastfeeding use
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester.
Contraindication
Hypersensitivity to penicillin.
Acute Overdose
Symptoms: Agitation, confusion, asterixis, hallucinations, stupor, coma, multifocal myoclonus, seizures and encephalopathy, hyperkalaemia.
Management: Symptomatic and supportive treatment.
Storage Condition
Store at room temperature.
Innovators Monograph
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